Elucidation of the mechanisms of the release of D-serine and the regulation of the activity of synaptic and extrasynaptic NMDA receptors
Project/Area Number |
25640005
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 神経科学 / 脳・神経 / 遺伝子 / 神経伝達物質受容体 / シナプス伝達 |
Outline of Final Research Achievements |
The NMDA receptor is associated with the modulation of synaptic transmission in the central nervous system and is related not only to the regulation of higher brain functions such as learning and memory but also to the etiology of various psychiatrical and neurological disorders at the level of the whole animal. The activation of NMDA receptors requires the binding of glutamate as well as the coagonist D-serine. In this project, we have found that the effects of D-serine on NMDA receptors in the CA1 region of the mouse hippocampal slice are different between synaptic and extrasynaptic NMDA receptors. Furthermore, we have obtained preliminary data suggesting the possibility that there is some abnormality in synaptic plasticity in the knockout mouse lacking serine racemase that produces D-serine in the brain.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain2014
Author(s)
Hamada, S., Ogawa, I., Yamasaki, M., Kiyama, Y., Watabe, A. M., Kassai, H., Nakano, K., Aiba, A., Watanabe, M. and Manabe, T.
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Journal Title
European Journal of Neuroscience
Volume: 40
Issue: 8
Pages: 3136-3146
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Elucidation of the molecular functions and LOF of the CDKL5, a causative gene for neurodevelopmental disorders2013
Author(s)
Tanaka, T., Okuda, K., Watanabe, N., Kobayashi, S., Manabe, T., Takao, K., Miyakawa, T., Fukaya, M., Sakagami, H. and Mizuguchi, T.
Organizer
The Japanese Society of Neuropathology
Place of Presentation
Tokyo
Related Report
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[Presentation] Roles of SNAP-25 phosphorylation in presynaptic short-term plasticity
Author(s)
Katayama, N., Yamamori, S., Fukaya, M., Watanabe, M., Takahashi, M. and Manabe, T.
Organizer
Japan Neuroscience Society
Place of Presentation
Kyoto
Related Report
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[Presentation] Presynaptic Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates short-term plasticity through the interaction with syntaxin-1A
Author(s)
Watanabe, Y., Katayama, N., Takeuchi, K., Sakimura, K., Manabe, T. and Igarashi, M.
Organizer
Japan Neuroscience Society
Place of Presentation
Kyoto
Related Report
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[Presentation] Functional studies of the CDKL5, a causative gene for neurodevelopmental disorders, by interactome screening and loss-of-function analyses
Author(s)
Okuda, K., Watanabe, A., Kobayashi, S., Manabe, T., Takao, K., Miyakawa, T., Fukaya, M., Sakagami, H., Nishioka, T., Amano, M., Kaibuchi, K., Mizuguchi, M. and Tanaka, T.
Organizer
Japan Neuroscience Society
Place of Presentation
Kyoto
Related Report
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