Bioinformatics analysis reveals a putative scenario for de novo origination of genes
Project/Area Number |
25640112
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
System genome science
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Research Institution | Kyushu Institute of Technology |
Principal Investigator |
Yada Tetsushi 九州工業大学, 大学院情報工学研究院, 教授 (10322728)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 遺伝子進化 / de novo誕生 / 分子進化 / 比較ゲノム / バイオインフォマティクス / 遺伝子 |
Outline of Final Research Achievements |
Recent advances in genome research clearly show that many genes originate de novo from non-genic DNA sequences. However, little is known about scenarios of the origination. We have sketched here a putative scenario of how genes arose from non-genic sequences by applying bioinformatics analysis to Saccharomyces cerevisiae genome. That is, we have reconstructed the homologous ancestral DNA sequences before and after de novo gene origination and have observed changes between the two sequences. A putative scenario which we have successfully sketched is as follows. (1)In the beginning was GC-rich genome region. (2)Neutral mutations were accumulated in the region. (3)ORFs were extended/combined, and then (4)translation signature (Kozak sequence) was recruited.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli2014
Author(s)
Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K and Akimitsu N.
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Journal Title
Molecular cell
Volume: 53
Issue: 3
Pages: 393-406
DOI
Related Report
Peer Reviewed / Open Access
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