Development of new therapy for malignant bone and soft tissue tumor by targeting bone marrow stromal cells
Project/Area Number |
15K10449
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 骨軟部腫瘍 / 骨髄間質細胞 / 整形外科 / 悪性骨軟部腫瘍 / 薬剤耐性 / 転移 |
Outline of Final Research Achievements |
The clinical prognosis of localized malignant bone and soft tissue tumors are improved by systemic chemotherapy. However, the prognosis of the advanced cases of those tumors remains dismal. In this study, we investigated the roles of bone marrow stem cells (BMSC), as well as tumor cells, in the tumor biology of malignant bone and soft tissue tumors. We found that, in Ewing's sarcoma, cadherin-11 on BMSC regulated the bone metastasis of Ewing's sarcoma cells. We also proved that, in synovial sarcoma, the activation of Erk pathway was critical for the drug resistance for pazopanib, a multi-kinase inhibitor.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone.2015
Author(s)
Hatano M, Matsumoto Y, Fukushi J, Matsunobu T, Endo M, Okada S, Iura K, Kamura S, Fujiwara T, Iida K, Fujiwara Y, Nabeshima A, Yokoyama N, Fukushima S, Oda Y, Iwamoto Y.
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Journal Title
Clin Exp Metastasis.
Volume: 32
Issue: 6
Pages: 579-591
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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