A proteomic analysis to identify novel proteins related to mechanisms of tumor cell invasion in myxofibrosarcoma
Project/Area Number |
15K20017
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Keio University |
Principal Investigator |
Kikuta Kazutaka 慶應義塾大学, 医学部(信濃町), 助教 (30383798)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | Myxofibrosarcoma / Invasion / Proteomics / DCBLD2 / 2D-DIGE / 粘液線維肉腫 / プロテオミクス / 浸潤性 / 浸潤性軟部腫瘍 / プロテオミクス解析 / 外科的切除断端 / 免疫染色 |
Outline of Final Research Achievements |
Myxofibrosarcoma (MFS) is a mesenchymal malignancy characterized by frequent recurrence even after radical wide resection. To optimize therapy for MFS patients, we aimed to identify candidate tissue biomarkers of MFS invasion potential. We performed protein profiling in invasive and non-invasive MFS and detected a number of differentially expressed proteins. Among them, DCBLD2 was identified as a novel factor associated with tumor cell invasion in MFS, suggesting its potential clinical application as a biomarker for MFS prognosis. This is the first report about possible clinical utility of DCBLD2 in sarcomas. Further investigation of the detected proteins may produce additional biomarkers or clinical targets in MFS.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma.2016
Author(s)
Morioka H, Takahashi S, Araki N, Sugiura H, Ueda T, Takahashi M, Yonemoto T, Hiraga H, Hiruma T, Kunisada T, Matsumine A, Susa M, Nakayama R, Nishimoto K, Kikuta K, Horiuchi K, Kawai A
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 479-479
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Osteoid osteoma of the acetabulum successfully treated with computed tomography-guided resection and ablation using a standard electrosurgical generator: a case report.2016
Author(s)
Kikuta K, Oguro S, Yamamoto T, Sekita T, Yamaguchi S, Susa M, Nishimoto K, Inoue M, Nakatsuka S, Sasaki A, Kameyama K, Nakamura M, Matsumoto M, Morioka H.
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Journal Title
Journal of Medical Case Reports
Volume: 10
Issue: 1
Pages: 348-348
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report2016
Author(s)
Kobayashi H, Kikuta K, Sekita T, Susa M, Nishimoto K, Sasaki A, Kameyama K, Sugita S, Hasegawa T, Nakamura M, Matsumoto M, Morioka H
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Journal Title
Journal of Medical Case Reports
Volume: 10
Issue: 1
Pages: 321-321
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 粘液線維肉腫浸潤性関連候補タンパク質同定のための 蛍光2次元電気泳動法を用いたプロテオーム解析2016
Author(s)
菊田一貴, 窪田大介, 吉田朗彦, 山口さやか, 中山ロバート, 森岡秀夫, 中村雅也, 松本守雄, 中馬広一, 川井章, 近藤格
Organizer
第67回日本電気泳動学会
Place of Presentation
釧路市観光国際交流センター(北海道釧路市)
Year and Date
2016-08-26
Related Report
Invited
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[Presentation] 小切開と術中イメージを併用したCTガイド下焼灼術をおこなった臼蓋部類骨骨腫の1 例2016
Author(s)
菊田一貴, 小黒草太, 関田哲也, 山口さやか, 須佐美知郎, 西本和正, 佐々木文, 亀山香織, 中村雅也, 松本守雄, 森岡秀夫
Organizer
第49回日本整形外科学会骨・軟部腫瘍学術集会
Place of Presentation
東京ドームホテル(東京都文京区)
Year and Date
2016-07-14
Related Report
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