Identification of possible biomarkers for the efficient physiotherapy after the CNS injury.
Project/Area Number |
23650327
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Kyushu University |
Principal Investigator |
OKADA SEIJI 九州大学, 医学(系)研究科(研究院), 准教授 (30448435)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | リハビリテーション医学 / ギガシークエンサー / 脊髄損傷 / リハビリテーション / レーザーマイクロダイセクション / トランスクリプトーム / 運動ニューロン / 網羅的遺伝子発現解析 |
Research Abstract |
To quantify the efficacy of physiotherapy after the central nervous system injury, we evaluate gene expression changes between before and after rehabilitation/disuse by combining selective nuclear/cellular sorting of motor neurons and transcriptome analysis using next-generation sequencer. After the complete transection of spinal cord at mid-thoracic level, we collected motor neurons located in the level of lumbar intumescence with laser micro dissection at three months after injury, and performed gene expression analysis. This method will contribute to identify the possible biomarkers for establishment of efficient rehabilitation programs.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Dedifferentiated chondrosarcoma of the cervical spine: a case report2013
Author(s)
Matsumoto Y, Takahashi Y, Harimaya K, Nakagawa T, Kawaguchi K, Okada S, Hayashida M, Doi T, Sakamoto A, Matsunobu T, Oda Y, Iwamoto Y
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Journal Title
World J Surg Oncol
Volume: 2
Issue: 1
Pages: 32-32
DOI
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Peer Reviewed
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[Journal Article] Hematoma of the ligamentum flavum in the thoracic spine: report of two cases and possible role of the transforming growth factor beta-vascular endothelial growth factor signaling axis in its pathogenesis2013
Author(s)
Matsumoto Y, Fujiwara T, Imamura R, Okada Y, Harimaya K, Doi T, Kawaguchi K, Okada S, Yamada Y, Oda Y, Iwamoto Y
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Journal Title
J Orthop Sci
Volume: 18
Issue: 2
Pages: 347-54
DOI
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Peer Reviewed
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[Journal Article] Analysis of the risk factors for tracheostomy in traumatic cervical spinal cord injury2012
Author(s)
Yugue I, Okada S, Ueta T, Maeda T, Mori E, Kawano O, Takao T, Sakai H, msuda M, Hayashi T, Morishita Y, Shiba K
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Journal Title
Spine
Volume: 37
Issue: 26
Pages: E1633-E1638
DOI
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Peer Reviewed
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[Journal Article] Chd2 interacts with H3.3 to determine myogenic cell fate2012
Author(s)
Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, Kumamaru H, Saiwai H, Tsubota T, Kurumizaka H, Akashi K, Tachibana T, Imbalzano AN, Ohkawa Y
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Journal Title
EMBO J
Volume: 31
Issue: 13
Pages: 2994-3007
DOI
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Peer Reviewed
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[Journal Article] Bioluminescent system for dynamic imaging of cell and animal behavior2012
Author(s)
Hara-Miyauchi C, Tsuji O, Hanyu A, Okada S, Yasuda A, Fukano T, Akazawa C, Nakamura M, Imamura T, Matsuzaki Y, Okano HJ, Miyawaki A, Okano H
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Journal Title
Biochem Biophys Res Commun
Volume: 419(2)
Issue: 2
Pages: 188-93
DOI
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Peer Reviewed
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[Journal Article] Extradural nodular fasciitis arising in the spinal canal2012
Author(s)
Kubota K, Okada S, Maeda T, Matsumoto Y, Sakamoto A, Doi T, Harimaya K, Saiwai H, Kumamaru H, Oda Y, Iwamoto Y
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Journal Title
Spine
Volume: 37
Issue: 2
Pages: E133-E137
DOI
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Peer Reviewed
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[Journal Article] Beneficial compaction of spinal cord lesion by migrating astrocytes through Glycogen Synthase Kinase-3 inhibition2011
Author(s)
Renault-Mihara F, Katoh H, Ikegami T, Iwanami A, Mukaino M, Tada H, Yasuda A, Nori S, Shibata S, Saito K, Matsushita M, Kaibuchi K, Okada S, Toyama Y, Nakamura M, and Okano H
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Journal Title
EMBO Mol Med
Volume: 3
Issue: 11
Pages: 682-96
DOI
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Peer Reviewed
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[Journal Article] Macrophage Infiltration Predicts a Poor Prognosis for the Human Ewing Sarcoma2011
Author(s)
Fujiwara T, Fukushi JI, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
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Journal Title
American Journal of Pathology
Volume: 179
Issue: 3
Pages: 1157-70
DOI
NAID
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Peer Reviewed
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[Presentation] 脊髄損傷後の自己修復メカニズム2012
Author(s)
岡田誠司, 熊丸浩仁, 久保田健介, 小早川 和 , 中村雅也 , Renault-Mihara Francois, 岡野栄之, 岩本幸英
Organizer
第27回日本整形外科学会基礎学術集会
Place of Presentation
名古屋
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