Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows
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- NANIWA Yousuke
- Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan Research Fellow of the Japan Society for the Promotion of Science
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- NAKATSUKASA Keisuke
- Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
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- SETSUDA Shohei
- Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
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- OISHI Shinya
- Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
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- FUJII Nobutaka
- Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
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- MATSUDA Fuko
- Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
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- UENOYAMA Yoshihisa
- Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
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- TSUKAMURA Hiroko
- Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
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- MAEDA Kei-ichiro
- Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
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- OHKURA Satoshi
- Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
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Abstract
Kisspeptin is a key molecule that stimulates gonadotropin secretion via release of gonadotropin-releasing hormone (GnRH). In the present study, our aim was to investigate whether kisspeptin has stimulatory effects on follicular development via GnRH/gonadotropin secretion in cows. Japanese Black beef cows were intravenously injected with full-length bovine kisspeptin [Kp-53 (0.2 or 2 nmol/kg)] or vehicle 5 days after they exhibited standing estrus (Day 0). In cows injected with Kp-53 at 2 nmol/kg, the follicular sizes of the first dominant follicles increased on Day 6 and thereafter. Ovulation of the first dominant follicle occurred in 1 out of 4 cows treated with Kp-53 at 2 nmol/kg. Injection of Kp-53 at 2 nmol/kg increased the concentration of plasma luteinizing hormone (LH) but not follicle-stimulating hormone, over a 4-h period following injection in all cows. The present study suggests that administration of full-length kisspeptin causes LH secretion, which is sustained for a few hours, and it is capable of stimulating follicular development and/or ovulation.
Journal
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 59 (6), 588-594, 2013
The Society for Reproduction and Development
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Details
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- CRID
- 1390001206338125056
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- NII Article ID
- 130003381852
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- NII Book ID
- AA10936678
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- COI
- 1:STN:280:DC%2BC2c%2Fjslynug%3D%3D
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- ISSN
- 13484400
- 09168818
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- NDL BIB ID
- 025084340
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- PubMed
- 24107742
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed