Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows

  • NANIWA Yousuke
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan Research Fellow of the Japan Society for the Promotion of Science
  • NAKATSUKASA Keisuke
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
  • SETSUDA Shohei
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
  • OISHI Shinya
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
  • FUJII Nobutaka
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
  • MATSUDA Fuko
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
  • UENOYAMA Yoshihisa
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
  • TSUKAMURA Hiroko
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
  • MAEDA Kei-ichiro
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
  • OHKURA Satoshi
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan

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Abstract

Kisspeptin is a key molecule that stimulates gonadotropin secretion via release of gonadotropin-releasing hormone (GnRH). In the present study, our aim was to investigate whether kisspeptin has stimulatory effects on follicular development via GnRH/gonadotropin secretion in cows. Japanese Black beef cows were intravenously injected with full-length bovine kisspeptin [Kp-53 (0.2 or 2 nmol/kg)] or vehicle 5 days after they exhibited standing estrus (Day 0). In cows injected with Kp-53 at 2 nmol/kg, the follicular sizes of the first dominant follicles increased on Day 6 and thereafter. Ovulation of the first dominant follicle occurred in 1 out of 4 cows treated with Kp-53 at 2 nmol/kg. Injection of Kp-53 at 2 nmol/kg increased the concentration of plasma luteinizing hormone (LH) but not follicle-stimulating hormone, over a 4-h period following injection in all cows. The present study suggests that administration of full-length kisspeptin causes LH secretion, which is sustained for a few hours, and it is capable of stimulating follicular development and/or ovulation.

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