Effect of Neurokinin B on the activity of the GnRH pulse generator
Project/Area Number |
25871109
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Integrative animal science
Animal production science
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Research Institution | National Institute of Agrobiological Sciences |
Principal Investigator |
Wakabayashi Yoshihiro 国立研究開発法人農業生物資源研究所, 動物生産生理機能研究ユニット, 主任研究員 (00510695)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | キスペプチン / neurokinin B / 弓状核 / ダイノルフィン / ニューロキニン / ニューロキニンB |
Outline of Final Research Achievements |
Neurokinin B (NKB) in the arcuate nucleus (ARC) kisspeptin neurons might regulate the pulsatile secretion of GnRH/luteinizing hormone (LH) in mammals, however physiological function of NKB still remains unclear. To verify the physiological function of NKB, goats bearing the guide cannula with recording electrodes in the ARC, where kisspeptin neurons are located, were received micro injection of NKB. The local injection of NKB evoked bursts of the ARC kisspeptin neurons and following secretion of LH. These findings suggest that NKB in the ARC kisspeptin neurons stimulates the neural activity of the ARC kisspeptin neurons to burst simultaneously. This burst might be neural source of the pulsatile secretion of GnRH/LH.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Ovarian and hormonal responses to follicular phase administration of investigational metastin/kisspeptin analog, TAK-683, in goats.2014
Author(s)
Goto, Y., Endo, N., Nagai, K., Ohkura, S., Wakabayashi, Y., Tanaka, A., Matsui, H., Kusaka, M., Okamura, H. and Tanaka, T.
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Journal Title
Reproduction in Domestic Animals
Volume: 49
Issue: 2
Pages: 338-342
DOI
Related Report
Peer Reviewed
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