Trichoblastoma with Abundant Plump Stromal Cells in a Dog

  • MINESHIGE Takayuki
    Research Institute of Biosciences, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
  • YASUNO Kyohei
    Research Institute of Biosciences, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
  • SUGAHARA Go
    Research Institute of Biosciences, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
  • TOMISHITA Yoshifumi
    Tomishita Animal Hospital, 2–17 Matsuomachi, Yahatahigashi-ku, Kitakyushu, Fukuoka 805–0032, Japan
  • SHIMOKAWA Namiko
    MONOLIS Co., Ltd., 8–31–6 Jindaijihigashimachi, Chofu, Tokyo 182–0012, Japan
  • KAMIIE Junichi
    Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
  • NISHIFUJI Koji
    Division of Animal Life Science, Graduate School, Tokyo University of Agriculture and Technology, 3–5–8 Saiwai-cho, Fuchu, Tokyo 183–8509, Japan
  • SHIROTA Kinji
    Research Institute of Biosciences, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan

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  • Pathology : Trichoblastoma with Abundant Plump Stromal Cells in a Dog

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Abstract

Histopathological and immunohistochemical examinations were made on a cutaneous tumor on the head of an 11-year-old female mixed-breed dog. The tumor was well demarcated and comprised multilobular structures of neoplastic epithelial cells with abundant plump peritumoral stromal cells. The neoplastic cells formed irregular cell cords or trabeculae and were arranged in characteristic palisades at the periphery. Immunohistochemically, neoplastic cells were positive for p63 and the several cytokeratins examined. In contrast, the plump peritumoral stromal cells were positive for vimentin and unevenly for nestin, a neuroepithelial stem cell protein. The stromal cells prominently proliferated in proximity to epithelial neoplastic cells, suggesting a close interaction between these two cell types.

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