Development of the new therapy using the ray radiation on inflammatory bowel disease
Project/Area Number |
25861205
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
|
Research Institution | Oita University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | LED光線 / 光線療法 / DSS誘導大腸炎 / disease activity index |
Outline of Final Research Achievements |
The body surface radiation to the 2.5% dextran sulfate sodium - induced colitis mouse of LED rays significantly reduced disease activity index score of the colitis and significantly decreased shortening of the length of large intestine. Whereas the significant change of the lymphocytes marker (CD4, CD8, B220, Foxp3) in murine spleen irradiated with LED rays was not found. The LED rays wavelength (patent pending) of a certain wavelength has a colitis improvement effect. A search of the further mechanism, optimal condition may lead to new therapy for inflammatory bowel disease.
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Report
(4 results)
Research Products
(3 results)