Altered Microglia in the Amygdala Are Involved in Anxiety-related Behaviors of a Copy Number Variation Mouse Model of Autism
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- Shigemori Tomoko
- Department of Pharmacology, Nippon Medical School Department of Pediatrics, Nippon Medical School
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- Sakai Atsushi
- Department of Pharmacology, Nippon Medical School
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- Takumi Toru
- , RIKEN Brain Science Institute
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- Itoh Yasuhiko
- Department of Pediatrics, Nippon Medical School
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- Suzuki Hidenori
- Department of Pharmacology, Nippon Medical School
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Abstract
Background and Purpose: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic basis. Although anxiety is a common major psychiatric condition in ASD, the underlying mechanisms of the anxiety are poorly understood. In individuals with ASD, evidence indicates a structural abnormality in the amygdala, a key component involved in anxiety and social behavior. Microglia, which are central nervous system-resident immune cells implicated in neurodevelopmental processes, are also reportedly altered in ASD. In the present study, we examined the involvement of microglia in the anxiety-related behaviors of ASD model mouse. Methods: Mice that have a 6.3-Mb paternal duplication (patDp/+) corresponding to human chromosome 15q11-q13 were used as an ASD model. Iba1, a microglial activation marker, was examined in the amygdala using immunofluorescence. Effects of perinatal treatment with minocycline, a microglial modulator, on anxiety-related behaviors were examined in neonatal and adolescent patDp/+ mice. Results: In patDp/+ mice, Iba1 was decreased in the basolateral amygdala at postnatal day 7, but not at postnatal days 37-40. Perinatal treatment with minocycline restored the Iba1 expression and reduced anxiety-related behaviors in patDp/+ adolescent mice. Conclusions: Perinatal microglia in the basolateral amygdala may play a pathogenic role in the anxiety observed in a mouse model of ASD with duplication of human chromosome 15q11-q13.
Journal
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- Journal of Nippon Medical School
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Journal of Nippon Medical School 82 (2), 92-99, 2015
The Medical Association of Nippon Medical School
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Details
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- CRID
- 1390001205094797952
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- NII Article ID
- 130005068463
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- ISSN
- 13473409
- 13454676
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- PubMed
- 25959200
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed