Basic study of the development of an evidence based early drug intervention for neuro-developmental diseases
Project/Area Number |
21591335
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Nippon Medical School |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SUZUKI Hidenori 日本医科大学, 大学院・医学研究科, 教授 (30221328)
SAKAI Atsushi 日本医科大学, 医学部, 助教 (30386156)
HANEDA Eisuke 日本医科大学, 大学院・医学研究科, ポストドクター (30453921)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 発達小児科学 / 脳・神経 / ストレス / セロトニン / 早期介入 / SSRI / セロトニン1A受容体 / 発達障害 |
Research Abstract |
We found that prenatal dexamethasone(DEX) exposure, which mimics some aspects of prenatal stress, induced anxiety-related behaviors in male offspring when they reached adulthood. Before the emergence of behavioral changes, abnormalities occurred in the serotonin(5-HT) signaling in the brain. During postnatal 3 week treatment with a selective serotonin reuptake inhibitor or a 5-HT1A receptor agonist prevented the emergence of behavioral abnormalities in the prenatally DEX-exposed offspring.
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Report
(4 results)
Research Products
(12 results)