Development of neuroprotective therapy for amyotrophic lateral sclerosis using serotonergic reagent
Project/Area Number |
24659431
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Okayama University |
Principal Investigator |
ASANUMA Masato 岡山大学, 医歯(薬)学総合研究科, 教授 (00273970)
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Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Ikuko 岡山大学, 大学院医歯薬学総合研究科, 助教 (40335633)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 筋萎縮性側索硬化症 / アストロサイト / セロトニン / 運動障害 / メタロチオネイン |
Outline of Final Research Achievements |
We examined neuroprotective effects of serotonin-1A receptor agonist 8-OH-DPAT on progressive motor neuron degeneration in amyotrophic lateral sclerosis (ALS) model mice and in primary culture cells. The pre-treatments of 8-OH-DPAT prior to onset of motor symptoms delayed disease onset. The chronic post-treatments of the drug after the onset significantly inhibited disease progression and showed protective effects on motor neuron loss in the cervical and lumber spinal cords in the ALS models. Furthermore, we revealed that the neuroprotective effects are based, in part, on expression and release of metallothionein in/from astrocytes via serotonin-1A receptors and sequent activation of transcription factor Nrf2.
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice2014
Author(s)
Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horigushi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H
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Journal Title
Am J Physiol Renal Physiol
Volume: 306
Issue: 1
Pages: 105-115
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of Bupropion and Pramipexole on Cell Proliferation in the Hippocampus of Adrenocorticotropic Hormone-Treated Rats2014
Author(s)
Onoue, Y., Kuwatsuka, K., Miyazaki, I., Asanuma, M., Kitamura, Y. and Sendo, T.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 37
Issue: 2
Pages: 327-330
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lack of dopaminergic inputs elongates the primary cilia of striatal neurons.2014
Author(s)
2.Miyoshi K, Kasahara K, Murakami S, Takeshima M, Kumamoto N, Sato A, Miyazaki I, Matsuzaki S, Sasaoka T, Katayama T, Asanuma M.
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Journal Title
PLoS One
Volume: 9(5)
Issue: 5
Pages: e97918-e97918
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation.2014
Author(s)
Ohmori, I., Kawakami, N., Liu, S., Wang, H., Miyazaki, I., Asanuma, M., Michiue, H., Matsui, H., Mashimo, T. and Ouchida, M.
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Journal Title
Epilepsia
Volume: 55
Issue: 10
Pages: 1558-1567
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The Mechanisms of Electroconvulsive Stimuli in BrdU-Positive Cells of the Dentate Gyrus in ACTH-Treated Rats2013
Author(s)
Kuwatsuka, K., Hayashi, H., Onoue, Y., Miyazaki, I., Koyama, T., Asanuma, M., Kitamura, Y. and Sendo, T.
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Journal Title
Journal of Pharmacological Sciences
Volume: 122
Issue: 1
Pages: 34-41
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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[Journal Article] Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models.2013
Author(s)
Asanuma, M., Miyazaki, I., Diaz-Corrales, F.J., Higashi, Y., Namba, M. and Ogawa, N.
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Journal Title
PLoS ONE
Volume: 8
Issue: 6
Pages: e65983-e65983
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models.2013
Author(s)
Miyazaki, I., Asanuma, M., Murakami, S., Takeshima, M., Torigoe, N., Kitamura, Y. and Miyoshi, K.
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Journal Title
Neurobiol. Dis.
Volume: 59
Pages: 244-256
DOI
Related Report
Peer Reviewed
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[Journal Article] Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression2013
Author(s)
Sogawa, N., Hazehara, Y., Kunitomo, K. Morita, Y., Bupsang, Y., Ohyama, K., Sogawa, C. and Kitayama, S
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Journal Title
Life Sci
Volume: 92
Issue: 12
Pages: 727-732
DOI
Related Report
Peer Reviewed
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[Presentation] Involvement of BDNF in doxorubicin and cyclophosphamide-induced spatial cognition in rats.2014
Author(s)
Kitamura, Y., Yoneda, S., Miyazaki, I., Asanuma, M., Sendo, T.
Organizer
44th Annual Meeting of Society for Neuroscience (Neuroscience 2014)
Place of Presentation
Washington, D,C.
Year and Date
2014-11-15 – 2014-11-19
Related Report
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[Presentation] Involvement of the 5-HT1A receptor function in the 8-OH-DPAT treatment on neurogenesis in ACTH-treated rats.
Author(s)
Kitamura, Y., Miyake, A., Hattori, S., Koyama, T., Miyazaki, I., Asanuma M. and Sendo, T.
Organizer
43rd Annual Meeting of Society for Neuroscience (Neuroscience2013)
Place of Presentation
San Diego
Related Report
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[Presentation] Ketamine exerts antidepressant-like effects during the forced swim test in adrenocorticotropic hormone-treated rats.
Author(s)
Nakamura, H., Yoneda, S., Miyake, A., Koyama, T., Miyazaki, I., Asanuma, M., Kitamura, Y. and Sendo, T.
Organizer
43rd Annual Meeting of Society for Neuroscience (Neuroscience2013)
Place of Presentation
San Diego
Related Report
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[Presentation] Comparative study of psychological response on treatment with doxorubicin and cyclophosphamide between rats and mice.
Author(s)
Yoneda, S., Hattori, S., Nakamura, H., Watanabe, S., Koyama, T., Miyazaki, I., Asanuma, M., Kitamura, Y. and Sendo, T.
Organizer
43rd Annual Meeting of Society for Neuroscience (Neuroscience2013)
Place of Presentation
San Diego
Related Report
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