Risk factor and mechanism of reactivation of hepatitis B virus following systemic chemotherapy
Project/Area Number |
24591428
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Nagoya City University |
Principal Investigator |
KUSUMOTO Shigeru 名古屋市立大学, 医学(系)研究科(研究院), 講師 (90423855)
|
Co-Investigator(Renkei-kenkyūsha) |
TANAKA Yasuhito 名古屋市立大学, 大学院医学研究科, 教授 (90336694)
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | B型肝炎ウイルス再活性化 / HBV再活性化 / がん分子標的治療 / B型肝炎 / がん化学療法 / HBV DNAモニタリング / 再活性化 |
Outline of Final Research Achievements |
Reactivation of hepatitis B virus is a potentially fatal complication following systemic chemotherapy. HBV reactivation may occur not only in patients with seropositive for HBsAg, but also in patients with seropositive for anti-HBc and/or anti-HBs (HBV resolved infection). This study demonstrated that if a potentially immune-enhancing drug is used for HBsAg-positive cancer patients with high HBV DNA levels, HBV reactivation-related death may occur despite antiviral prophylaxis before hepatitis onset. This study also showed that HBV reactivation may occur not only in patients with B-cell lymphoma who received rituximab-containing chemotherapy, but also with T-cell lymphoma. In near future, new molecular target drugs may change the risk of HBV reactivation.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma.2015
Author(s)
Masaki A, Ishida T, Maeda Y, Suzuki S, Ito A, Takino H, Ogura H, Totani H, Yoshida T, Kinoshita S, Narita T, Ri M, Kusumoto S, Inagaki A, Komatsu H, Niimi A, Ueda R, Utsunomiya A, Inagaki H, Iida S.
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Journal Title
Clin Cancer Res.
Volume: in press
NAID
Related Report
Peer Reviewed
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[Journal Article] Reactivation of hepatitis B virus (HBV) infection in adult T-cell leukemia-lymphoma patients with resolved HBV infection following systemic chemotherapy2015
Author(s)
Totani H, Kusumoto S, Ishida T, Masuda A, Yoshida T, Ito A, Ri M, Komatsu H, Murakami S, Mizokami M, Ueda R, Niimi A, Inagaki H, Tanaka Y, Iida S.
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Journal Title
International Journal of Hematology
Volume: 印刷中
Issue: 4
Pages: 398-404
DOI
Related Report
Peer Reviewed
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[Journal Article] Multicenter cooperative case survey of Hepatitis B virus reactivation by chemotherapeutic agents.2015
Author(s)
Takahashi H, Ikeda M, Kumada T, Osaki Y, Kondo S, Kusumoto S, Ohkawa K, Nadano S, Furuse J, Kudo M, Ito K, Yokoyama M, Okusaka T, Shimoyama M, Mizokami M
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Journal Title
Hepatol Res
Volume: Jan 27
Issue: 12
Pages: 1220-1227
DOI
Related Report
Peer Reviewed
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[Journal Article] HTLV-1 bZIP factor-specific CD4 T cell responses in adult T cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation.2014
Author(s)
Narita T, Ishida T, Masaki A, Suzuki S, Ito A, Mori F, Yamada T, Ri M, Kusumoto S, Komatsu H, Miyazaki Y, Takatsuka Y, Utsunomiya A, Niimi A, Iida S, Ueda R.
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Journal Title
J Immunol.
Volume: 192
Issue: 3
Pages: 940-947
DOI
Related Report
Peer Reviewed
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[Journal Article] Antitumor effects of bevacizumab in a microenvironment-dependent human adult T-cell leukemia/lymphoma mouse model2014
Author(s)
Mori F, Ishida T, Ito A, Sato F, Masaki A, Narita T, Suzuki S, Yamada T, Takino H, Ri M, Kusumoto S, Komatsu H, Hishizawa M, Imada K, Takaori-Kondo A, Niimi A, Ueda R, Inagaki H, Iida S
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Journal Title
European Journal of Haematology
Volume: 92
Issue: 3
Pages: 219-228
DOI
Related Report
Peer Reviewed
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[Journal Article] Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma.2012
Author(s)
Suzuki S, Masaki A, Ishida T, Ito A, Mori F, Sato F, Narita T, Ri M, Kusumoto S, Komatsu H, Fukumori Y, Nishikawa H, Tanaka Y, Niimi A, Inagaki H, Iida S, Ueda R.
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Journal Title
Cancer Sci.
Volume: 103
Pages: 1764-1773
Related Report
Peer Reviewed
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