Research of sphingolipids as a novel tumor marker for clinical study
Project/Area Number |
25430135
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor diagnostics
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 腫瘍マーカー / 脂質メディエーター / メタボローム解析 / アミノ酸 |
Outline of Final Research Achievements |
Using the quantitative method of high sensitivity mass spectrometry for sphingolipid, healthy subjects and blood sphingolipid of each cancer patient was analyzed quantitatively. Especially, it was investigated clinical applicability as a novel tumor marker of SlP. Plasma S1P concentrations were 410±67 nM, 620±129 nM, 484±151 nM, and 491±106 nM in healthy, esophageal cancer, stomach cancer, sarcoma, respectively. Esophageal cancer patient plasma S1P concentration was for the first time revealed that it is significantly higher compared to the healthy subjects. Using metabolome analysis profiling for cancer disease analysis as some new biomarker candidates, in particular, I found the possibility of cystine.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo2014
Author(s)
Nakanaga K, Hama K, Kano K, Sato T, Yukiura H, Inoue A, Saigusa D, Tokuyama H, Tomioka Y, Nishina H, Kawahara A, Aoki J
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Journal Title
J. Biochem
Volume: 155
Issue: 4
Pages: 235-241
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regul ation of GATA32013
Author(s)
Akiyama Y, Kikuchi K, Saigusa D, Suzuki T, Takeuchi Y, Mishima E, Yamamoto Y, Ishida A, Sugawara D, Jinno D, Shima H, Toyohara T, Suzuki C, Souma T, Moriguchi T, Tomioka Y, Ito S, Abe T.
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Journal Title
PLoS One
Volume: 8
Issue: 7
Pages: e66518-e66518
DOI
Related Report
Peer Reviewed
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