Investigation of novel protective factors for Parkinson's disease through molecular genetic-epidemiological analysis of the gout gene
Project/Area Number |
25670307
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Epidemiology and preventive medicine
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Research Institution | National Defense Medical College |
Principal Investigator |
MATSUO Hirotaka 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 講師 (00528292)
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Co-Investigator(Kenkyū-buntansha) |
SHINOMIYA Nariyoshi 防衛医科大学校, 医学教育部医学科専門課程, 教授 (40505260)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | パーキンソン病 / 遺伝疫学 / 痛風遺伝子 / 尿酸 / 分子疫学 / ゲノム / 遺伝子 / 神経疾患 |
Outline of Final Research Achievements |
We collected genomic DNA from approximately 100 Parkinson's disease (PD) patients and 100 healthy controls with detailed clinical information, and constructed a resource for the basis of genetic epidemiological studies. Furthermore, we created the basis of researches which enables us to analyze more than 500 PD cases. We then performed an analysis to investigate the association between the pathogenic mutation (variant) of ABCG2 (a gout gene) and PD. The dysfunctional variant significantly associated with the later PD onset, while it markedly associated with the earlier gout onset. This result revealed that ABCG2 dysfunction could have a significant neuroprotective effect for later onset of PD. Our findings also showed the physiological model and pathphysiological model wih ABCG2 which locates in blood brain barrier (BBB).
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout.2015
Author(s)
Matsuo H, Tomiyama H, Satake W, Chiba T, Onoue H, Kawamura Y, Nakayama A, ShimizuS, Sakiyama M, Funayama M, Nishioka K, Shimizu T, Kaida K, Kamakura K, Toda T, Hattori N, ShinomiyaN.
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Journal Title
Ann Clin Transl Neurol
Volume: 2
Issue: 3
Pages: 302-306
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout.2015
Author(s)
Chiba T, Matsuo H, Kawamura Y, Nagamori S, Nishiyama T, Wei L, Nakayama A, Nakamura T, Sakiyama M, Takada T, Taketani Y, Suma S, Naito M, Oda T, Kumagai H, Moriyama Y, Ichida K, Shimizu T, Kanai Y, Shinomiya N.
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Journal Title
Arthritis Rheumatol.
Volume: 67(1)
Issue: 1
Pages: 281-287
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] ABCG2 SNP typing by HRM method; an effective method for gout/hyperuricemia risk evaluation.2013
Author(s)
Takada Y, Matsuo H, Sakiyama M, Nakayama A, Fuji A, Shimizu S, Chiba T, Nakasima H, Matsumura K, Suzuki K, Hamajima N, Niwa K, Suzuki S, Uchino S, Kobayashi Y, Shinomiya N.
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Journal Title
J Clin Welfare
Volume: 10
Pages: 64-69
Related Report
Peer Reviewed
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