Molecular mechanism of gastric carcinogenesis through restricted dedifferentiation by Helicobacter pylori CagA
Project/Area Number |
26860495
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
|
Research Institution | The University of Tokyo |
Principal Investigator |
FUJII YUMIKO 東京大学, 医学(系)研究科(研究院), 特任助教 (30722334)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ヘリコバクター・ピロリ / 化生 |
Outline of Final Research Achievements |
Chronic infection with cagA-positive Helicobacter pylori is associated with gastric diseases including gastritis, metaplasia and carcinoma. In this project, we demonstrated that CagA protein induces precancerous mucosal lesion defined as spasmolytic polypeptide expressing metaplasia (SPEM) in mouse gastric corpus. We also found that CagA deregulates the phosphorylation status of the E-cadherin cytoplasmic domain in gastric epithelial cells.
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Report
(3 results)
Research Products
(2 results)