Analysis of therapeutic effect of anti-TIM-4 mAb on inflammatory disease.
Project/Area Number |
25461503
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Collagenous pathology/Allergology
|
Research Institution | Juntendo University |
Principal Investigator |
Akiba Hisaya 順天堂大学, 医学(系)研究科(研究院), 准教授 (60338316)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 自己免疫疾患 / 抗炎症作用 / アレルギー疾患 / 細胞表面分子機能 / 細胞表面分子 |
Outline of Final Research Achievements |
In this study, mice were treated with anti-TIM-4 mAb during the effector phase of collagen-induced arthritis (CIA). Treatment with anti-TIM-4 mAb just before or after the onset or even at later stage of CIA significantly suppressed the development and progression by reducing pro-inflammatory cytokines in the ankle joints without affecting T or B cell responses. Consistently, clinical arthritis scores of collagen antibody-induced arthritis (CAIA) were significantly reduced in anti-TIM-4-treated mice with a concomitant decrease of pro-inflammatory cytokines in the joints. In vitro, macrophages secreted pro-inflammatory cytokines in response to TIM-4-Ig protein and LPS, which were reduced by the anti-TIM-4 mAb. The anti-TIM-4 mAb also inhibited the differentiation and bone resorbing activity of osteoclasts. The therapeutic effect of anti-TIM-4 mAb is mediated by the inhibition of pro-inflammatory cytokine production by inflammatory cells, osteoclast differentiation, and bone resorption.
|
Report
(4 results)
Research Products
(22 results)
-
[Journal Article] Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation2015
Author(s)
1)Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K
-
Journal Title
Experimental Lung Research
Volume: 41
Issue: 7
Pages: 370-382
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis2013
Author(s)
Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H
-
Journal Title
Journal of Immunology
Volume: 191巻
Issue: 9
Pages: 4562-4572
DOI
Related Report
Peer Reviewed
-
[Journal Article] Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival2013
Author(s)
Yeung M, McGrath M, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka L, and Najafian N
-
Journal Title
J Immunol
Volume: 191
Issue: 8
Pages: 4447-4455
DOI
Related Report
Peer Reviewed
-
[Journal Article] TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.2013
Author(s)
Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
-
Journal Title
Immunity
Volume: 39
Issue: 6
Pages: 1070-1081
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] TIM-3 regulates innate immune cells to induce fetomaternal tolerance.2013
Author(s)
Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle PJ, Smith BD, Boenisch O, Najafian N, Akiba H, Yagita H, Guleria I.
-
Journal Title
J Immunol
Volume: 190
Issue: 1
Pages: 88-96
DOI
Related Report
Peer Reviewed
-
[Journal Article] T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis.2013
Author(s)
Foks AC, Ran IA, Wasserman L, Frodermann V, Ter Borg MN, de Jager SC, van Santbrink PJ, Yagita H, Akiba H, Bot I, Kuiper J, van Puijvelde GH.
-
Journal Title
Arterioscler Thromb Vasc Biol
Volume: 33
Issue: 11
Pages: 2558-65
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-