The significance of CD169+ macrophages in patients with malignant tumors
Project/Area Number |
26460454
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Kumamoto University |
Principal Investigator |
OHNISHI Koji 熊本大学, 大学院生命科学研究部(医), 助教 (40613378)
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Co-Investigator(Kenkyū-buntansha) |
菰原 義弘 熊本大学, 大学院生命科学研究部(医), 准教授 (40449921)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | マクロファージ / リンパ節 / CD169 / 癌免疫 / リンパ節マクロファージ / がん免疫 / 腫瘍免疫 / 分子マーカー |
Outline of Final Research Achievements |
As the expectation for cancer immunotherapy increases, the importance of cancer immunity monitoring is increasing. We focused on the importance of lymph node macrophages in cancer immunity and performed the following analysis. CD 169 expression of lymph node macrophages was analyzed in patients with melanoma, uterine body cancer, pancreatic cancer, breast cancer. As a result, it was revealed that cancer immunity mediated by CD8 positive T cells is elevated in cases with high CD 169 expression, and survival rate after surgery is good. In culture experiments, it was revealed that CD169 highly expressed macrophages highly express CCL8 and CXCL10 having lymphocyte activating action.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Infiltration of tumor-associated macrophages is involved in CD44 expression in clear cell renal cell carcinoma.2016
Author(s)
Ma C, Komohara Y, Ohnishi K, Shimoji T, Kuwahara N, Sakumura Y, Matsuishi K, Fujiwara Y, Motoshima T, Takahashi W, Yamada S, Kitada S, Fujimoto N, Nakayama T, Eto M, Takeya M.
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Journal Title
Cancer Sci.
Volume: Epub
Issue: 5
Pages: 700-707
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.2016
Author(s)
Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A
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Journal Title
J Clin Invest
Volume: 126
Issue: 9
Pages: 3417-3432
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Expression of anaphylatoxin C5a receptor in gastric cancer: Implications with vascular invasion and patient outcome.2016
Author(s)
Nitta, H., Shimose, T., Emi, Y., Imamura, T., Ohnishi, K., Kusumoto, T., Yamamoto. M., Fukuzawa, K., Takahashi, I., Higashi, H., Tsuji, A., Akagi, Y., Oki, E., Maehara, Y., & Baba, H.
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Journal Title
Med. Oncol.
Volume: 33
Issue: 11
Pages: 118-118
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas2015
Author(s)
Yoshihiro Komohara, Tomoko Morita, Dorcas A. Annan, Hasita Horlad, Koji Ohnishi, Sohsuke Yamada, Toshiyuki Nakayama, Shohei Kitada, Shinya Suzu, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Koichi Akashi, Motohiro Takeya, Masahisa Jinushi
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Journal Title
Cancer immunology research
Volume: 3
Issue: 9
Pages: 999-1007
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma.2015
Author(s)
Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y.
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Journal Title
Cancer Immunol Res.
Volume: 3
Issue: 12
Pages: 1356-1363
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of CD204-Positive Tumor-Associated Macrophages in Adult T-Cell Leukemia/Lymphoma2014
Author(s)
Yoichi Saito, Yoshihiro Komohara, Daisuke Niino, Hasita Horlad, Koji Ohnishi, Hiroto Takeya, Hiroya Kawaguchi, Hirokazu Shimizu, Koichi Ohshima, Motohiro Takeya
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Journal Title
Journal of Clinical and Experimental Hematopathology
Volume: 54
Issue: 1
Pages: 59-65
DOI
NAID
ISSN
1346-4280, 1880-9952
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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