Metabolic Responses to High-Fat or Low-Fat Meals and Association with Sympathetic Nervous System Activity in Healthy Young Men
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- NAGAI Narumi
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University Department of Nutritional Science, Faculty of Health and Welfare, Okayama Prefectural University
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- SAKANE Naoki
- Department of Preventive Medicine, Clinical Research Institute, Center for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center
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- MORITANI Toshio
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
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Abstract
The present study was designed to investigate the metabolic and sympathetic responses to a high-fat meal in humans. Fourteen young men (age: 23.6±0.5 y, BMI: 21.3±0.4 kg/m2) were examined for energy expenditure and fat oxidation measured by indirect calorimetry for 3.5h after a high-fat (70% energy from fat) or an isoenergetic lowfat (20% energy from fat) meal served in random order. The sympathetic nervous system (SNS) activity was assessed using power spectral analysis of heart rate variability (HRV). After the high-fat meal, increases in thermoregulatory SNS activity (very low-frequency component of HRV, 0.007-0.035 Hz, 577.4±45.9 vs. 432.0±49.3 ms2, p<0.05) and fat oxidation (21.0±5.3 vs. 13.3±4.3 g, p<0.001) were greater than those after the low-fat meal. However, thermic effects of the meal (TEM) were lower after the high-fat meal than after the low-fat meal (27.5±11.2 vs. 36.1±10.9 kcal, p<0.05). In conclusion, the high' fat meal can stimulate thermoregulatory SNS and lipolysis, but resulted in lower TEM, suggesting that a high proportion of dietary fat intake, even with a normal daily range of calories, may be a potent risk factor for further weight gain.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 51 (5), 355-360, 2005
Center for Academic Publications Japan
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Details
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- CRID
- 1390282681300977536
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- NII Article ID
- 10016770109
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- NII Book ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD2MXht1ehsbbL
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL BIB ID
- 7681066
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed