Effects of obesity, metabolic syndrome, and non-alcoholic or alcoholic elevated liver enzymes on incidence of diabetes following lifestyle intervention: A subanalysis of the J-DOIT1
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- Sakane Naoki
- Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Kotani Kazuhiko
- Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center Divison of Community and Family Medicine, Jichi Medical University
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- Suganuma Akiko
- Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Takahashi Kaoru
- Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center Hyogo Health Service Association
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- Sato Juichi
- Department of General Medicine/Family & Community Medicine, Nagoya University Graduate School of Medicine
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- Suzuki Sadao
- Department of Public Health, Nagoya City University Graduate School of Medical Sciences
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- Izumi Kazuo
- National Center for Global Health and Medicine
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- Kato Masayuki
- Health Management Center and Diagnostic Imaging Center, Toranomon Hospital
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- Noda Mitsuhiko
- Ichikawa Hospital, International University of Health and Welfare
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- Nirengi Shinsuke
- Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Kuzuya Hideshi
- Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center Koseikai Takeda Hospital
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Abstract
<p>Objectives: Using annual health check-up data, the aim of this study was to identify target populations for lifestyle interventions to effectively prevent diabetes in a real-world setting.</p><p>Methods: The Japan Diabetes Outcome Intervention Trial-1, a prospective, cluster-randomized controlled trial, was launched to test if year-long telephone-delivered lifestyle support by health professionals can prevent the development of type 2 diabetes (T2D) in people with impaired fasting glucose (IFG) identified at health check-ups. A total of 2607 participants aged 20-65 years with IFG were randomized to an intervention arm (n = 1240) or a control arm (n = 1367). We performed subgroup analysis to examine the effects of the intervention on the incidence of T2D in participants with body mass index (BMI) ≥25, metabolic syndrome (MetS), and non-alcoholic or alcoholic elevated liver enzymes at the baseline. Cox regression analysis adjusted for sex was used to calculate the hazard ratios (HRs).</p><p>Results: In addition to IFG, the presence of BMI ≥25, MetS, and elevated liver enzymes increased the incidence of diabetes by two- or three-fold. During a median follow-up period of 4.9 years, only the non-alcoholic elevated liver enzyme group showed a low incidence rate owing to lifestyle interventions (adjusted HR: 0.42, 95% confidence interval: 0.18-0.98).</p><p>Conclusion: The results suggest that people who have IFG and non-alcoholic elevated liver enzymes are a good target population for lifestyle interventions to effectively reduce the incidence of diabetes in a real-world setting.</p>
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 62 (1), n/a-, 2020
Japan Society for Occupational Health
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Details
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- CRID
- 1390565134840127488
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- NII Article ID
- 130007815498
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- ISSN
- 13489585
- 13419145
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed