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Associations of HLA class I alleles in Japanese patients with Crohn’s disease

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Abstract

Previous studies have suggested that the human leukocyte antigen (HLA) is involved in the etiology of Crohn’s disease (CD); however, few reports are available on the association between HLA class I antigens and CD in Japan. In this study, we performed association analysis of HLA class I antigens in CD using 208 Japanese patients and 384 healthy controls. We identified novel positive associations between CD and HLA-A*02:01 (odds ratio (OR)=1.64, P=0.016) and HLA-A*02:07 (OR=2.31, P=0.0067) and confirmed previously reported positive associations between CD and HLA-Cw*14:02 (OR=2.18, P=0.0021) and HLA-B*51:01 (OR=1.70, P=0.033). We also identified novel negative associations between CD and HLA-A*24:02 (OR=0.60, P=0.0047) and HLA-B*07:02 (OR=0.38, P=0.0041). Although the associations were not significant after full Bonferroni correction, we suggested that HLA class I genes have dual functions, susceptibility and resistance in controlling the development of CD.

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Acknowledgements

We thank all of the participants for providing blood samples. This work was supported by a Health Labour Sciences Research Grant for Research on Rare and Intractable Diseases from The Ministry of Health, Labour and Welfare, and by a Grant-in-Aid for Scientific Research on Innovative Areas, MEXT KAKENHI Grant Number 22133009, in Japan.

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Correspondence to T Sasazuki.

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Oryoji, D., Hisamatsu, T., Tsuchiya, K. et al. Associations of HLA class I alleles in Japanese patients with Crohn’s disease. Genes Immun 16, 54–56 (2015). https://doi.org/10.1038/gene.2014.61

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