Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000
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- Arai Hidenori
- Department of Geriatric Medicine, Kyoto University School of Medicine, Kyoto, Japan.
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- Yamamoto Akira
- National Cardiovascular Center, Osaka, Japan.
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- Matsuzawa Yuji
- Department of Internal Medicine, Osaka University, Osaka, Japan.
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- Saito Yasushi
- Department of Internal Medicine, Chiba University, Chiba, Japan.
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- Yamada Nobuhiro
- Department of Internal Medicine, Tsukuba University, Ibaraki, Japan.
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- Oikawa Shinichi
- Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
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- Mabuchi Hiroshi
- Department of Internal Medicine, Kanazawa University, Ishikawa, Japan.
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- Teramoto Tamio
- Department of Internal Medicine, Teikyo University, Tokyo, Japan.
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- Sasaki Jun
- International University of Health and Welfare, Tochigi, Japan.
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- Nakaya Noriaki
- Fussa Hospital, Tokyo, Japan.
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- Itakura Hiroshige
- Ibaraki Christian University, Ibaraki, Japan.
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- Ishikawa Yuichi
- Faculty of Health Sciences, Kobe University, Hyogo, Japan.
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- Ouchi Yasuyoshi
- Department of Geriatric Medicine, University of Tokyo, Tokyo, Japan.
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- Horibe Hiroshi
- Keisen Clinic, Tokyo, Japan.
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- Egashira Tohru
- Department of Advanced Technology and Development, BML, Inc., Tokyo, Japan.
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- Hattori Hiroaki
- Department of Advanced Technology and Development, BML, Inc., Tokyo, Japan.
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- Shirahashi Nobuo
- Osaka City University Medical School, Osaka, Japan.
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- Kita Toru
- Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Bibliographic Information
- Other Title
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- Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000 Serum Lipid Level Survey 2000 in Japan
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Abstract
We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII</B> (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, Int14 +1 G → A, and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (−514 → CT) with HDL-cholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.
Journal
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 12 (5), 240-250, 2005
Japan Atherosclerosis Society
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Details
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- CRID
- 1390282679410456832
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- NII Article ID
- 130004444144
- 10018365279
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- NII Book ID
- AA11018976
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- COI
- 1:CAS:528:DC%2BD28XnvVyrs7s%3D
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- ISSN
- 18803873
- 13403478
- http://id.crossref.org/issn/13403478
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- PubMed
- 16205020
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed