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Novel splicing-factor mutations in juvenile myelomonocytic leukemia
Leukemia Open Access 20 February 2012
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Niemeyer CM, Kratz CP . Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: molecular classification and treatment options. Br J Haematol 2008; 140: 610–624.
Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S et al. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature 2009; 460: 904–908.
Dunbar AJ, Gondek LP, O'Keefe CL, Makishima H, Rataul MS, Szpurka H et al. 250 K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. Cancer Res 2008; 68: 10349–10357.
Grand FH, Hidalgo-Curtis CE, Ernst T, Zoi K, Zoi C, McGuire C et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood 2009; 113: 6182–6192.
Yamamoto G, Nannya Y, Kato M, Sanada M, Levine RL, Kawamata N et al. Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am J Hum Genet 2007; 81: 114–126.
Chen Y, Takita J, Hiwatari M, Igarashi T, Hanada R, Kikuchi A et al. Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies. Genes Chromosomes Cancer 2006; 45: 583–591.
Loh ML, Sakai DS, Flotho C, Kang M, Fliegauf M, Archambeault S et al. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood 2009; 114: 1859–1863.
Thien CB, Langdon WY . Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl. Oncogene 1997; 15: 2909–2919.
Acknowledgements
We thank Shinji Mochizuki, MD, Division of Hematology/Oncology, Saitama Children's Medical Center, and Junko Takita, MD, Kohmei Ida, MD, Department of Pediatrics, Graduate School of Medicine, University of Tokyo, and Kazuko Kudo, Department of Hematology/Oncology, Shizuoka Children's Hospital, for providing the JMML samples. We also thank Mrs Chisato Murata and Miss Sayaka Takeuchi for their excellent technical assistance. This work was supported by a grant for Cancer Research, and a grant for Research on Children and Families from the Ministry of Health, Labor, and Welfare of Japan, a Grant-in-Aid for Scientific Research (B, C) and Exploratory Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and by a Research grant for Gunma Prefectural Hospitals.
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Shiba, N., Kato, M., Park, Mj. et al. CBL mutations in juvenile myelomonocytic leukemia and pediatric myelodysplastic syndrome. Leukemia 24, 1090–1092 (2010). https://doi.org/10.1038/leu.2010.49
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DOI: https://doi.org/10.1038/leu.2010.49
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