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References
Lewis SM, Dacie JV . The aplastic anaemia—paroxysmal nocturnal haemoglobinuria syndrome. Br J Haematol 1967; 13: 236–251.
Takeda J, Miyata T, Kawagoe K, Iida Y, Endo Y, Fujita T et al. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal-nocturnal hemoglobinuria. Cell 1993; 73: 703–711.
Ware RE, Rosse WF, Howard TA . Mutations within the Piga gene in patients with paroxysmal nocturnal hemoglobinuria. Blood 1994; 83: 2418–2422.
Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV . Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med 1995; 333: 1253–1258.
Inoue N, Izui-Sarumaru T, Murakami Y, Endo Y, Nishimura JI, Kurokawa K et al. Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood 2006; 108: 4232–4236.
Sugimori C, Padron E, Caceres G, Shain K, Sokol L, Zhang L et al. Paroxysmal nocturnal hemoglobinuria and concurrent JAK2(V617F) mutation. Blood Cancer J 2012; 2: e63.
Shen W, Clemente MJ, Hosono N, Yoshida K, Przychodzen B, Yoshizato T et al. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria. J Clin Invest 2014; 124: 4529–4538.
Sakaguchi H, Okuno Y, Muramatsu H, Yoshida K, Shiraishi Y, Takahashi M et al. Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet 2013; 45: 937–941.
Katagiri T, Kawamoto H, Nakakuki T, Ishiyama K, Okada-Hatakeyama M, Ohtake S et al. Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages. Stem Cells 2013; 31: 536–546.
Katagiri T, Qi Z, Ohtake S, Nakao S . GPI-anchored protein-deficient T cells in patients with aplastic anemia and low-risk myelodysplastic syndrome: implications for the immunopathophysiology of bone marrow failure. Eur J Haematol 2011; 86: 226–236.
Hindson CM, Chevillet JR, Briggs HA, Gallichotte EN, Ruf IK, Hindson BJ et al. Absolute quantification by droplet digital PCR versus analog real-time PCR. Nat Methods 2013; 10: 1003–1005.
Raskind WH, Ferraris AM, Najfeld V, Jacobson RJ, Moohr JW, Fialkow PJ . Further evidence for the existence of a clonal Ph-negative stage in some cases of Ph-positive chronic myelocytic leukemia. Leukemia 1993; 7: 1163–1167.
Sloma I, Jiang X, Eaves AC, Eaves CJ . Insights into the stem cells of chronic myeloid leukemia. Leukemia 2010; 24: 1823–1833.
Akashi K . Guest editorial: leukemia stem cell. Int J Hematol 2013; 98: 625–626.
Schmidt M, Rinke J, Schafer V, Schnittger S, Kohlmann A, Obstfelder E et al. Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status. Leukemia 2014; 28: 2292–2299.
Acknowledgements
This work was supported by MEXT KAKENHI (Grant-in-Aid for Scientific Research (B), Grant Number: 24390243) and MEXT KAKENHI (Grant-in-Aid for Young Scientists (B), Grant Number: 26860363) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Author contributions
RT and TK contributed equally to this work. SN developed the concept of the study and supervised the project. RT, TK and SN designed the experiments. RT, TK, KK, RKCW, SO and SN performed the experiments and analyzed the data. RT, AM, HG, IM and TM were involved in the patient’s treatment. RT, TK, KK, SO and SN wrote the paper. All authors approved the final version of this paper for submission.
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Tominaga, R., Katagiri, T., Kataoka, K. et al. Paroxysmal nocturnal hemoglobinuria induced by the occurrence of BCR-ABL in a PIGA mutant hematopoietic progenitor cell. Leukemia 30, 1208–1210 (2016). https://doi.org/10.1038/leu.2015.268
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DOI: https://doi.org/10.1038/leu.2015.268
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