Development of novel therapy against glioma stem cells using super catalytic antibodies.
Project/Area Number |
15K10337
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Saga University |
Principal Investigator |
Abe Tatsuya 佐賀大学, 医学部, 教授 (40281216)
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Co-Investigator(Kenkyū-buntansha) |
宇田 泰三 公益財団法人九州先端科学技術研究所, ナノテク研究室, 特別研究員 (20232837)
籾井 泰朋 大分大学, 医学部, 助教 (20534192)
河島 雅到 佐賀大学, 医学部, 准教授 (20383565)
増岡 淳 佐賀大学, 医学部, 助教 (50359949)
中原 由紀子 佐賀大学, 医学部, 講師 (50380770)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 脳腫瘍 / 幹細胞 / スーパー抗体酵素 / 腫瘍幹細胞 / 創薬 |
Outline of Final Research Achievements |
Malignant brain tumor shows poor prognosis.MASUOKA any papers about glioblastoma (GBM) stem cells (GSCs) are reported to be an important factor. Our collaborative research produced super catalytic antibodies possessing serine protease-like characteristics. We perfumed screening with various super catalytic antibodies in human glioma cell lines and several GSCs. We found several clones showing anti-tumor effects against human glioma cell lines and GSCs in vitro. One clone against tight junction may suppress GSC’s growth to inhibit sphere formation. However, further studies are required to confirm whether these clones could be new anticancer drug in vivo. We would like to develop novel anticancer agents in brain and other solid tumor through translational research in the future.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Possible involvement of pericytes in intra-plaque hemorrhage of carotid stenosis.2018
Author(s)
Tanaka T, Ogata A, Masuoka J, Mizokami T, Wakamiya T, Nakahara Y, Inoue K, Shimokawa S, Yoshioka F, Momozaki N, Sakata S, Abe T
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Journal Title
Journal of Neurosurgery
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Carotid artery stenosis with a high-intensity signal plaque on time-of-flight magnetic resonance angiography and association with evidence of intraplaque hypoxia.2017
Author(s)
Ogata A, Kawashima M, Wakamiya T, Nishihara M, Masuoka J, Nakahara Y, Ebashi R, Inoue K, Takase K, Irie H, Abe T
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Journal Title
Journal of Neurosurgery
Volume: 126
Issue: 6
Pages: 1873-1878
DOI
Related Report
Peer Reviewed
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[Journal Article] SLC44A1–PRKCA fusion in papillary and rosette-forming glioneuronal tumor.2016
Author(s)
Nagaishi M, Nobusawa S, Matsumura N, Kono F, Ishiuchi S, Abe T, Ebato M, Wang Y, Hyodo A, Yokoo H, Nakazato Y.
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Journal Title
J Clin Neurosci.
Volume: 23
Pages: 73-75
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis.2016
Author(s)
Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, Tsuboi K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu, T Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Nakagawa Y, Miyatake SI.
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Journal Title
Neuro-Oncology Practice.
Volume: 3
Pages: 272-280
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation on the middle cranial fossa.2016
Author(s)
Fudaba H, Abe T, Morishige M, Momii Y, Kashima K, Yamada A, Nagatomi H, Natsume A, Hirato J, Nakazato Y, Fujiki M
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Journal Title
Neuropathology,
Volume: 36
Issue: 6
Pages: 579-583
DOI
Related Report
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[Journal Article] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis.2016
Author(s)
Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, , Terasaka S, Tabei Y, Nakamura H, Nagane M, Tsuboi K, Houkin K Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu, T Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Nakagawa Y, Miyatake SI.
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Journal Title
Neuro-Oncology Practice
Volume: 3
Related Report
Peer Reviewed
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[Presentation] Multicenter randomized placebo-controlled trial of autologous formalin-fixed tumor vaccine for newly-diagnosed LTBK-03 glioblastomas.2017
Author(s)
Muragaki Y, Maruyama T, Ishikawa E, Nitta M, Ikuta S, Tsuboi K, Matsumura A, Nakamura H, Abe T, Saito R, Tabei Y, Arakawa Y,Momii Y, Karasawa K, Matsutani M, Ohno T, Nakazato Y, Maebayashi K
Organizer
22ND ANNUAL SCIENTIFIC MEETING AND EDUCATION DAY OF THE SOCIETY FOR NEURO-ONCOLOGY.
Related Report
Int'l Joint Research
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[Presentation] 中枢神経系浸潤型アスペルギルス症に対する外科治療.2017
Author(s)
増岡 淳, 桃崎 明彦, 坂本 祐史, 正島 弘隆, 高口 素史, 井上 浩平, 緒方 敦之,中原 由紀子, 高瀬 幸徳, 下川 尚子, 阿部 竜也
Organizer
(一社)日本脳神経外科学会第76回学術総会.
Related Report
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[Presentation] 頸動脈狭窄症プラーク内出血におけるペリサイトと薬事療法の関連性.2017
Author(s)
緒方敦之,田中達也,溝上泰一朗,若宮富浩,増岡 淳,中原由紀子,下川尚子,高瀬幸徳,井上浩平,桃﨑宣明,坂田修治,阿部竜也
Organizer
第18回日本分子脳神経外科学会.
Related Report
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[Presentation] 頸動脈狭窄症プラーク内出血におけるペリサイトと薬剤療法の関連性.2017
Author(s)
緒方 敦之, 田中 達也1,2, 溝上 泰一朗, 若宮 富浩, 増岡 淳, 中原 由紀子,下川 尚子, 高瀬 幸徳, 井上 浩平, 桃崎 宣明, 坂田 修治, 阿部 竜也
Organizer
(一社)日本脳神経外科学会第76回学術総会.
Related Report
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[Presentation] 当院における頸動脈海綿静脈洞瘻の治療成績.2017
Author(s)
高瀬 幸徳, 緒方 敦之, 増岡 淳, 中原 由紀子, 下川 尚子, 井上 浩平, 高口 素史,正島 弘隆, 坂本 祐史, 桃崎 明彦, 阿部 竜也
Organizer
(一社)日本脳神経外科学会第76回学術総会.
Related Report
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[Presentation] 二分脊椎に伴う側弯症患者におけるCurved Planar Reconstruction画像の有用性2015
Author(s)
吉岡 史隆,下川 尚子,高口 素史,古川 隆,伊藤 寛,緒方 敦之,高瀬 幸徳,中原 由紀子,増岡 淳,河島 雅到,阿部 竜也
Organizer
第32回日本二分脊椎研究会.
Place of Presentation
東京
Year and Date
2015-07-04
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