Analysis of association between chronic inflammation and tumorigenesis in skin using psoriasis mouse model
Project/Area Number |
16K19104
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Nagoya University |
Principal Investigator |
Mii Shinji 名古屋大学, 医学系研究科, 特任助教 (80646505)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | CD109 / 皮膚発癌 / 扁平上皮癌 / 炎症性発癌 / 病理学 / 癌 / 炎症 |
Outline of Final Research Achievements |
In this study, we investigated the role of CD109 in skin tumorigenesis using a two-stage carcinogenesis model in CD109-deficient mice with chronic skin inflammation. Although no significant difference was found in conversion rates from papilloma to carcinoma between wild-type and CD109-deficient mice in the carcinogenesis model, we observed fewer and smaller papillomas in CD109-deficient mice than in wild-type mice. Additionally, immunofluorescence analysis showed that SMAD2 phosphorylation and NRF2 expression were enhanced in primary keratinocytes from CD109-deficient mice compared with in those from wild-type mice. These results suggest that CD109 deficiency suppresses skin tumorigenesis by enhancing TGF-β/SMAD/NRF2 pathway activity.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex2018
Author(s)
Liang Weng , Yi-Peng Han, Atsushi Enomoto, Yasuyuki Kitaura, Shushi Nagamori, Yoshikatsu Kanai, Naoya Asai, Jian An, Maki Takagishi, Masato Asai, Shinji Mii, Takashi Masuko, Yoshiharu Shimomura, Masahide Takahashi.
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Journal Title
PLoS Biology
Volume: 16
Issue: 3
Pages: e2005090-e2005090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis2016
Author(s)
Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K
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Journal Title
Int J Oncol
Volume: 49
Issue: 4
Pages: 1369-1376
DOI
Related Report
Peer Reviewed
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