Epigenetic mechanisms of development of follicular helper-T like tumors
Project/Area Number |
25461407
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | lymphoma / RHOA / TET2 / AITL / follicular helper T cell / BCL6 / T細胞リンパ腫 / メチル化 |
Outline of Final Research Achievements |
Angioimmunoblastic T-cell lymphoma (AITL) is a hematologic malignancy. AITL tumor cells have features of follicular helper T cells. Loss-of-function mutations in TET2, encoding an epigenetic regulator, are frequently found in AITL samples. We clarified mechanisms of AITL development using a lymphoma model in Tet2 gene-trap mice, and genomic analysis of human AITL. TET2 gene-trap mice developed lymphoma having features of follicular helper T cells, accompanying hypermehtylation of silencer of Bcl6. We also identified RHOA mutations as well as TET2 mutations in 70% of AITL samples.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma2016
Author(s)
Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, (9名), Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S
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Journal Title
Blood
Volume: 127
Issue: 5
Pages: 596-604
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Identification of a fusion gene composed of a Hippo pathway gene MST2 and a common translocation partner ETV6 in a recurrent translocation t(8;12)(q22;p13) in acute myeloid leukemia.2015
Author(s)
Ogawa S, Yokoyama Y, Suzukawa K, Nanmoku T, Kurita N, Seki M, Maie K, Suyama T, Takaiwa N, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Chiba S
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Journal Title
Annals of Hematology
Volume: 94
Issue: 8
Pages: 1431-1433
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Complete Remission in Systemic Skin Interdigitating Dendritic Cell Sarcoma after ABVD Chemotherapy2015
Author(s)
Kyogoku C, Seki M, Ogawa S, Miyamoto K, Ito Y, Kurita N, Yokoyama Y, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Fujishima F, Ichinohasama R, Nakamura S, Chiba S.
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Journal Title
Journal of Clinical and Experimental Hematopathology
Volume: 55
Issue: 1
Pages: 33-37
DOI
NAID
ISSN
1346-4280, 1880-9952
Related Report
Peer Reviewed / Open Access
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[Journal Article] Acute painful crisis in a female Nigerian patient with sickle cell disease2015
Author(s)
Nin S, Seki M, Maie K, Kuroda A, Miyamoto K, Ogawa S, Ito Y, Kurita N, Yokoyama Y, Sakata Yanagimoto M, Obara N, Hasegawa Y, Ogino Y, Ito T, Chiba S.
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Journal Title
Rinsho Ketsueki
Volume: 56
Issue: 1
Pages: 30-34
DOI
NAID
ISSN
0485-1439, 1882-0824
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice.2014
Author(s)
Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchida K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S
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Journal Title
Blood Cancer J.
Volume: 12
Issue: 12
Pages: e264-e264
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Detection of the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and related lymphomas using quantitative allele-specific PCR2014
Author(s)
Nakamoto-Matsubara R, Sakata-Yanagimoto M, Enami T, Yoshida K, Yanagimoto S, Shiozawa Y, Nanmoku T, Satomi K, Muto H, Obara N, Kato T, Kurita N, Yokoyama Y, Izutsu K, Ota Y, Sanada M, Shimizu S, Komeno T, Sato Y, Ito T, Kitabayashi I, Takeuchi K, Nakamura N, Ogawa S, Chiba S.
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Journal Title
PLoS ONE
Volume: 9
Issue: 10
Pages: e109714-e109714
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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