Molecular analysis of pediatric myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML) by next generation sequencer
Project/Area Number |
25461611
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Gunma Institute of Public Health and Environmental Sciences |
Principal Investigator |
SOTOMATSU Manabu 群馬県衛生環境研究所, 研究企画係, 研究員 (70251113)
|
Co-Investigator(Kenkyū-buntansha) |
HAYASHI Yasuhide 群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)
OHKI Kentarou 国立成育医療研究センター, 小児血液・腫瘍研究部, 室長 (50400966)
PARK Myoung-ja 群馬県衛生環境研究所, 研究企画係, 研究員 (50450375)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 遺伝子 / ゲノム / マイクロアレイ / 癌 / 臨床 |
Outline of Final Research Achievements |
We analysed CSF3R exons 14 and 17, and calreticulin (CALR) exon 9, in pediatric AML(521 cases), JMML(40), MDS(20) and essential thrombocythemia (ET;21). CSF3R mutations were found in 10 (1.2%) of 521 patients with AML; 2 in exon 14 and 8 in exon 17. All of the patients with the mutations in CSF3R exon 17 had chromosomal translocations. No CSF3R mutations were found in cases of MDS, JMML or ET. CALR mutation was found in one ET patient. We examined 41 transient abnormal myelopoiesis (TAM), 49 DS-AMKL and 19 non-DS-AMKL samples by whole-exome sequencing. TAM appeared to be caused by a single GATA1 mutation and constitutive trisomy 21. Subsequent AMKL evolves through the acquisition of additional mutations, including cohesin components and other epigenetic regulators. We identified CBFA2T3-GLIS2, NUP98-JARID1A, and RBM15-MKL1, in 12, 4, and 2 patients out of 44 pediatric non-DS-AMKL patients. CBFA2T3-GLIS2 is considered to be a significant poor prognostic factor in non-DS-AMKL patients.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML.2015
Author(s)
Jo A, Mitani S, Shiba N, Hayashi Y, Hara Y, Takahashi H, Tsukimoto I, Tawa A, Horibe K, Tomizawa D, Taga T, Adachi S, Yoshida T, Ichikawa H
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Journal Title
Leukemia
Volume: 29
Issue: 5
Pages: 1067-1083
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.2015
Author(s)
Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Kato M, Chiba K, Tanaka H, Hoshino N, Nagae G, Shiozawa Y, Okuno Y, Hosoi H, Tanaka Y, Okita H, Miyachi M, Souzaki R, Taguchi T, Koh K, Hanada R, Kato K, Nomura Y, Akiyama M, Oka A, Igarashi T, Miyano S, Aburatani H, Hayashi Y, Ogawa S, Takita J.
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Journal Title
Nat Commun.
Volume: 6
Issue: 1
Pages: 7557-7557
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial.2015
Author(s)
Tokumasu M, Murata C, Shimada A, Ohki K, Hayashi Y, Saito AM, Fujimoto J, Horibe K, Nagao M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Tomizawa D, Taga T, Tawa A, Tanaka S, Heike T, Adachi S
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Journal Title
Leukemia
Volume: 29
Issue: 12
Pages: 2438-2441
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3-ITD, KMT2A-PTD, and NUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial.2015
Author(s)
Shiba N, Ohki K, Kobayashi T, Hara Y, Yamato G, Tanoshima R, Ichikawa H, Tomizawa D, Park MJ, Shimada A, Sotomatsu M, Arakawa H, Horibe K, Adachi S, Taga T, Tawa A, Hayashi Y.
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Journal Title
Br J Haematol.
Volume: 172
Issue: 4
Pages: 581-91
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Gene alterations involving the CRLF2-JAK pathway and recurrent gene deletions in Down syndrome-associated acute lymphoblastic leukemia in Japan.2014
Author(s)
Hanada I, Terui K, Ikeda F, Toki T, Kanezaki R, Sato T, Kamio T, Kudo K, Sasaki S, Takahashi Y, Hayashi Y, Inukai T, Kojima S, Koike K, Kosaka Y, Kobayashi M, Imaizumi M, Mitsui T, Hori H, Hara J, Horibe K, Nagai J, Goto H, Ito E.
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Journal Title
Genes Chromosomes Cancer
Volume: 53
Issue: 11
Pages: 902-910
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Acute myeloid leukaemia with myelodysplastic features in children2014
Author(s)
Kinoshita A, Miyachi H, Matsushita H, Yabe M, Taki T, Watanabe T, Saito AM, Tomizawa D, Taga T, Takahashi H, Matsuo H, Kodama K, Ohki K, Hayashi Y, Tawa A, Horibe K, Adachi S.
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Journal Title
Br J Haematol
Volume: 167
Issue: 1
Pages: 80-86
DOI
Related Report
Peer Reviewed
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[Journal Article] Mutations of the GATA2 and CEBPA genes in paediatric acute myeloid leukaemia.2014
Author(s)
Shiba N, Funato M, Ohki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
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Journal Title
Brit J Haematol
Volume: 印刷中
Issue: 1
Pages: 142-159
DOI
Related Report
Peer Reviewed
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[Journal Article] Recurrent CDC25C mutations drive malignant transformation in FPD/AML2014
Author(s)
Yoshimi A, Toya T, Kawazu M, Ueno T, Tsukamoto A, Iizuka H, Nakagawa M, Nannya Y, Arai S, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Ichikawa M, Mano H, Kurokawa M
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Journal Title
Nature communications
Volume: 5
Issue: 1
Pages: 4770-4770
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] WT1 mutation in pediatric patients with acute myeloid leukemia: A study of the Japanese Childhood AML Cooperative Study Group2013
Author(s)
Sano H, Shimada A, Tabuchi K, Taki T, Murata C, Park M, Sotomatsu Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
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Journal Title
Int J Hematol
Volume: 98
Issue: 4
Pages: 437-445
DOI
Related Report
Peer Reviewed
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[Journal Article] NUP98-NSD1 related gene expression signature is strongly associated with a poor prognosis in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group Cooperative Study Group2013
Author(s)
Shiba N, Ichikawa H, Taki T, Park M, Jo A, Mitani S, Shimada A, Sotomatsu M, Arakawa H, Tabuchi K, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
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Journal Title
Genes Chromosomes Cancer
Volume: 52
Issue: 7
Pages: 683-693
DOI
Related Report
Peer Reviewed
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[Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome2013
Author(s)
Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
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Journal Title
Blood
Volume: 121(16)
Issue: 16
Pages: 3181-3184
DOI
Related Report
Peer Reviewed
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[Journal Article] Cytomegalovirus Retinitis During Maintenance Therapy for T-Cell Acute Lymphoblastic Leukemia2013
Author(s)
Wakai K, Sano H, Shimada A, Shiozawa Y, Park MJ, Sotomatsu M, Yanagisawa R, Koike K, Kozawa K, Ryo A, Tsukagoshi H, Kimura H, Hayashi Y
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Journal Title
J Pediatr Hematol Oncol
Volume: 35
Issue: 2
Pages: 162-163
DOI
Related Report
Peer Reviewed
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[Presentation] A Combination of EVI1 and PRDM16 Expression Clarified the Clinical Features of Intermediate/High Risk Patients in Pediatric Acute Myeloid Leukemia2015
Author(s)
Yamato G, Shiba N, Hara Y, Park M, Sotomatsu M, Ohki K, Ichikawa H, Tomizawa D, Taga T, Horibe K, Tawa A, Arakawa H, Adachi S, Hayashi Y
Organizer
57th ASH Annual Meeting and Exposition
Place of Presentation
Orland
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] The Outcome of Relapsed Childhood Core Binding Factor Acute Myeloid Leukemia: A Report from the JPLSG AML-05R Study2015
Author(s)
Moritake H, Tanaka S, Nakayama H, Miyamura T, Iwamoto S, Shimada A, Terui K, Saito A, Shiba N, Hayashi Y, Tomizawa D, Taga T, Goto H, Manabe A, Horibe K, Mizutani S, Adachi S
Organizer
57th ASH Annual Meeting and Exposition
Place of Presentation
Orland
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] Detection of Novel Pathogenic Gene Rearrangements in Pediatric Acute Myeloid Leukemia By RNA Sequencing2015
Author(s)
Shiba N, Yoshida K, Shiraishi Y, Hara Y, Yamato G, Kaburaki T, Sanada M, Oki K, Tomizawa D, Sotomatsu M, Arakawa H, Horibe K, Park M, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y
Organizer
57th ASH Annual Meeting and Exposition
Place of Presentation
Orland
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] High BMP2 Expression Is a Poor Prognostic Factor and a Good Candidate to Identify CBFA2T3-GLIS2-like High-Risk Subgroup in Pediatric Acute Myeloid Leukemia2015
Author(s)
Hara Y, Yamato G, Shiba N, Ohki K, Park M, Tomizawa D, Taki T, Taga T, Arakawa H, Tawa A, Horibe K, Adachi S, Hayashi Y
Organizer
57th ASH Annual Meeting and Exposition
Place of Presentation
Orland
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] RNA seqにより見いだされた新規遺伝子の解析と臨床像2015
Author(s)
原 勇介, 柴 徳生, 大和 玄季, 大木 健太郎, 朴 明子, 外松 学, 滝 智彦, 吉田 健一, 眞田 昌, 富澤 大輔, 荒川 浩一, 堀部 敬三, 多賀 崇, 足立 壮一, 多和 昭雄, 宮野 悟, 小川 誠司, 林 泰秀
Organizer
第57回日本小児血液・がん学会学術総会
Place of Presentation
甲府
Year and Date
2015-11-27
Related Report
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[Presentation] 小児急性骨髄性白血病におけるPRDM16遺伝子とEVI1遺伝子発現の臨床的意義2015
Author(s)
大和 玄季, 柴 徳生, 原 勇介, 朴 明子, 外松 学, 大木 健太郎, 市川 仁, 富澤 大輔, 多賀 崇, 堀部 敬三, 多和 昭雄, 荒川 浩一, 足立 壮一, 林 泰秀
Organizer
第57回日本小児血液・がん学会学術総会
Place of Presentation
甲府
Year and Date
2015-11-27
Related Report
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[Presentation] The prognostic impact of PRDM16 gene expression in both adult and pediatric acute myeloid leukemia2015
Author(s)
Yamato G, Yamaguchi H, Handa H, Shiba N, Wakita S, Inokuchi K, Hara Y, Ohki K, Park M, Sotomatsu M, Ichikawa H, Tomizawa D, Taga T, Adachi S, Horibe K, Tawa A, Arakawa H, Hayashi Y
Organizer
第77回日本血液学会学術総会
Place of Presentation
金沢
Year and Date
2015-10-16
Related Report
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[Presentation] RNA sequencing reveals the comprehensive gene alterations of pediatric acute myeloid leukemia2015
Author(s)
Shiba N, Yoshida K, Sanada M, Shiraishi Y, Hara Y, Yamato G, Ohki K, Park M, Tomizawa D, Sotomatsu M, Arakawa H, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y
Organizer
第77回日本血液学会学術総会
Place of Presentation
金沢
Year and Date
2015-10-16
Related Report
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[Presentation] 家族性骨髄異形成症候群とその原因候補遺伝子2015
Author(s)
高岡 賢輔, 河津 正人, 吉見 昭秀, 遠矢 嵩, 小林 隆, 南谷 泰仁, 上野 博則, 原田 浩徳, 林 泰秀, 間野 博行, 黒川 峰夫
Organizer
第74回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
2015-10-08
Related Report
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[Presentation] 中間リスク、高リスク小児急性骨髄性白血病における新たな治療層別化の試み2015
Author(s)
柴 徳生, 原 勇介, 大木 健太郎, 大和 玄季, 富澤 大輔, 多賀 崇, 多和 昭雄, 荒川 浩一, 足立 壮一, 林 泰秀, JPLSG AML委員会
Organizer
第118回日本小児科学会
Place of Presentation
大阪
Year and Date
2015-04-17
Related Report
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[Presentation] The Prognostic Impact of High MEL1 Gene Expression in Pediatric Acute Myeloid Leukemia. 56th ASH Annual Meeting and Exposition2014
Author(s)
Shiba N, Ohki K, Hara Y, Yamato G, Park M, Ichikawa H, Kobayashi T, Tomizawa D, Sotomatsu M, Arakawa H, Horibe K, Taga T, Adachi S, Tawa A, Hayashi Y.
Organizer
56th ASH Annual Meeting and Exposition
Place of Presentation
San Francisco
Year and Date
2014-12-06
Related Report
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[Presentation] Clinical Features of Patients with ASXL1 and ASXL2 Mutations in Pediatric Acute Myeloid Leukemia.2014
Author(s)
Yamato G, Shiba N, Yoshida K, Ohki K, Park M, Hara Y, Tomizawa D, Sotomatsu M, Taga T, Adachi S, Tawa A, Horibe K, Arakawa H, Ogawa S, Hayashi Y.
Organizer
56th ASH Annual Meeting and Exposition
Place of Presentation
San Francisco
Year and Date
2014-12-06
Related Report
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[Presentation] 小児急性骨髄性白血病におけるASXL1、ASXL2遺伝子変異と臨床像2014
Author(s)
大和 玄季, 柴 徳生, 吉田 健一, 大木 健太郎, 朴 明子, 原 勇介, 外松 学, 多賀 崇, 富澤 大輔, 足立 壮一, 多和 昭雄, 堀部 敬三, 荒川 浩一, 小川 誠司, 林 泰秀.
Organizer
第56回日本小児血液・がん学会学術集会
Place of Presentation
岡山
Year and Date
2014-11-29
Related Report
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[Presentation] ダウン症における一過性異常骨髄増殖症の形態学的特徴 JPLSG TAM-10形態中央診断の解析2014
Author(s)
濱 麻人, 村松 秀城, 長谷川 大輔, 朴 明子, 岩本 彰太郎, 多賀 崇, 伊藤 悦朗, 柳沢 龍, 康 勝好, 林 泰秀, 足立 壮一, 水谷 修紀, 渡邉 健一郎.
Organizer
第56回日本小児血液・がん学会学術集会
Place of Presentation
岡山
Year and Date
2014-11-28
Related Report
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[Presentation] CSF3R and CALR mutations and cytogenetic findings in pediatric myeloid malignancies.2014
Author(s)
Sano H, Ohki K, Park M, Shiba N, Hara Y, Sotomatsu M, Tomizawa D, Taga T, Kiyokawa N, Tawa A, Horibe K, Adachi A, Hayashi Y.
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-11-01
Related Report
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[Presentation] ダウン症における一過性異常骨髄増殖症の形態学的特徴 JPLSG TAM-10形態中央診断の解析2014
Author(s)
濱 麻人, 村松 秀城, 長谷川 大輔, 朴 明子, 岩本 彰太郎, 多賀 崇, 伊藤 悦朗, 柳沢 龍, 康 勝好, 林 泰秀, 足立 壮一, 水谷 修紀, 渡邉 健一郎.
Organizer
第117回日本小児科学会学術集会
Place of Presentation
名古屋
Year and Date
2014-04-13
Related Report
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[Presentation] Recurrent CDC25C mutations drive malignant transformation in FPD/AML.2014
Author(s)
Yoshimi A, Toya T, Kawazu M, Ueno T, Tsukamoto A, Iizuka1 H, Nakagawa M, Nannya Y, Arai S, Ichikawa M, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Mano H, Kurokawa M.
Organizer
AACR Annual Meeting 2014
Place of Presentation
San Diego, U.S.A.
Year and Date
2014-04-05 – 2014-04-09
Related Report
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[Presentation] Whole-Exome Resequencing Identifies Somatic Mutations Of BCOR and BCORL1 Transcriptional Corepressor Genes and Major Cohesin Complex Component Genes In Pediatric Acute Myeloid Leukemia.2013
Author(s)
Shiba N, Ohki K, Nagata Y, Kon A, Okuno Y,Shiraishi Y, Kato M, Park MJ, Ohki K, Takita J, Kanazawa T, Kudo K, Ito E, Sanada M, Tomizawa D, Tawa A, Adachi S, Miyano S, Ogawa S, Hayashi Y.
Organizer
55rd Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans
Related Report
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[Presentation] Low Frequency and Poor Prognosis Of MLL-Partial Tandem Duplications In Pediatric Acute Myeloid Leukemia Using MLPA Method: The Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 Trial.2013
Author(s)
Ohki K, Park MJ, Sano H, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, Hayashi Y.
Organizer
55rd Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans
Related Report
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[Presentation] Whole Exome Sequencing Reveals Clonal Evolution Pattern and Driver Mutations Of Relapsed Pediatric AML.2013
Author(s)
Yoshida K, Shiba N, Shiraishi Y, Shimada A, Terui K, Kato M, Okuno Y, Nagata Y, Kon A, Yoshizato T, Matsunawa, M, Chiba K, Tanaka H, Sanada M, Miyano S, Ito E, Hayashi Y, Ogawa S.
Organizer
55rd Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans
Related Report
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[Presentation] Comprehensive Fusion Gene Analysis Of Pediatric Non-Down Syndrome Acute Megakaryoblasitc Leukemia.2013
Author(s)
Hara Y, Shiba n, Ohki K, Park MJ, Tomizawa D, Taga T, Saito A, Fujimoto J, Arakawa H, Tawa A, Horibe K, Adachi S, Hayashi Y.
Organizer
55rd Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans
Related Report
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[Presentation] CSF3R Gene Mutations In Myeloid Malignancy Of Childhood.2013
Author(s)
Sano H, Ohki K, Park MJ, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, Hayashi Y.
Organizer
55rd Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans
Related Report
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[Presentation] NUP98-MSD1 gene fusion is a strong poor prognostic factor in pediatric AML.
Author(s)
Hara Y, Shiba N, Shimada A, Kudo K, Tomizawa D, Taga T, Horibe K, Adachi S, Arakawa H, Tawa A, Hayashi Y.
Organizer
45th Congress of the International Society of Pediatric Oncology.
Place of Presentation
Hong Kong
Related Report
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[Presentation] 小児non-Down急性巨核芽球性白血病における遺伝子解析.
Author(s)
原 勇介, 柴 徳生, 大木健太郎, 朴 明子, 富澤大輔, 多賀 崇, 足立壮一, 荒川浩一, 多和昭雄, 堀部敬三, 林 泰秀.
Organizer
第72回日本癌学会学術総会
Place of Presentation
横浜
Related Report
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[Presentation] NUP98-NSD1 gene fusion is a strong poor prognostic factor in pediatric AML.
Author(s)
Hara Y, Shiba N, Ichikawa H, Taki T, Shimada A, Kudo K, Tomizawa D, Taga T, Adachi S, Arakawa H, Tawa A, Hayashi Y.
Organizer
The 75th Annual Meeting of the Japanese Society of Hematolgy.
Place of Presentation
札幌
Related Report
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[Presentation] Genetic basisi of myeloid leukemogenesisi in Down syndrome.
Author(s)
Yoshida K, Toki T, Okuno Y, Kanezaki R, Shiraishi Y, Sanada M, Park MJ, Terui K, Kon A, Nagata Y, Sato-Otsubo A, Sato Y, Wang R, Shiba N, Chiba K, Tanaka H, Hama A, Muramatsu H, Hasegawa D, Nakamura K, Kanegane H, Tsukamoto K, Adachi S, Kawakami K, Hayashi Y, Miyano S, Kojima S, Ito E, Ogawa S.
Organizer
The 75th Annual Meeting of the Japanese Society of Hematolgy.
Place of Presentation
札幌
Related Report
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[Presentation] Gata2 mutations are found in pediatric AML but not in other leukemias including JMML.
Author(s)
Hara Y, Shiba N, Funato M, Oki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
Organizer
The 75th Annual Meeting of the Japanese Society of Hematolgy.
Place of Presentation
札幌
Related Report
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[Presentation] Whole-exome resequencing reveals novel pathogenetic gene mutations in pediatric AML.
Author(s)
Shiba N, Yoshida K, Okuno Y, Shiraishi Y, Nagata Y, Kon A, Chiba K, Tanaka H, Ohki K, Kato M, Terui K, Park MJ, Kanazawa T, Takita J, Kudo K, Arakawa H, Ito E, Sanada M, Miyano S, Ogawa S, Hayashi Y.
Organizer
The 75th Annual Meeting of the Japanese Society of Hematolgy.
Place of Presentation
札幌
Related Report
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[Presentation] 急性骨髄性白血病におけるWT1遺伝子変異の解析.
Author(s)
佐野弘純, 嶋田 明, 田渕 健, 滝 智彦, 村田知里, 朴 明子, 大木健太郎, 外松 学, 足立壮一, 多和昭雄, 小林良二, 堀部敬三, 土田昌宏, 花田良二, 月本一郎, 林 泰秀.
Organizer
第55回日本小児血液・がん学会学術集会
Place of Presentation
福岡
Related Report
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[Presentation] 小児骨髄造血器腫瘍におけるCSF3R遺伝子異常の解析.
Author(s)
佐野仁志, 大木健太郎, 朴 明子, 柴 徳生, 原 勇介, 外松 学, 足立壮一, 堀部敬三, 多和昭雄, 花田良二, 月本一郎, 林 泰秀.
Organizer
第55回日本小児血液・がん学会学術集会
Place of Presentation
福岡
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