Analysis of the role of circadian clock gene in leukemogenesis
Project/Area Number |
26461421
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Yamaguchi University |
Principal Investigator |
YUJIRI Toshiaki 山口大学, 医学(系)研究科(研究院), 准教授 (80346551)
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 時計遺伝子 / 白血病 |
Outline of Final Research Achievements |
The circadian rhythm, defined as daily oscillation in various biological processes, is controlled by an endogenous clock in most normal cells in the body. Circadian rhythm disruption by shift work is associated with greater risk for cancer development and poor prognosis, suggesting a putative tumor-suppressive role for circadian rhythm homeostasis. Recent findings demonstrate a previously unrecognized role for the core circadian clock genes in acute myeloid leukemia. In hematopoietic cancers, the regulatory role of circadian clock genes has not yet been entirely clarified. Using cell lines, primary leukemic cells, and a genetically engineered mouse model of leukemia, we have characterized the effects of circadian rhythm disruption on leukemogenesis. The drugs that alter the circadian rhythm may sensitize leukemia cells to traditional anti-cancer therapies and facilitate targeting of leukemic stem cells to eliminate disease more effectively.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Diagnostic challenge of Diamond-Blackfan anemia in mothers and children by whole-exome sequencing2017
Author(s)
Ichimura T, Yoshida K, Okuno Y, Yujiri T, Nagai K, Nishi M, Shiraishi Y, Ueno H, Toki T, Chiba K, Tanaka H, Muramatsu H, Hara T, Kanno H, Kojima S, Miyano S, Ito E, Ogawa S, Ohga S.
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Journal Title
Int J Hematol.
Volume: 105
Issue: 4
Pages: 515-520
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults2016
Author(s)
Takahiko Yasuda, Shinobu Tsuzuki, Masahito Kawazu, Fumihiko Hayakawa, Shinya Kojima, Toshihide Ueno, Naoto Imoto, Shinji Kohsaka, Akiko Kunita, Koichiro Doi, Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Yasunori Ueda, Yasutaka Aoyama, Shigeki Ohtake, Junko Takita, Eirin Sai, Masafumi Taniwaki, et al.
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Journal Title
Nature genetics
Volume: in press
Issue: 5
Pages: 409-417
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Impact of MRD and TKI on allogeneic hematopoietic cell transplantation for Ph+ALL: a study from the Adult ALL WG of the JSHCT.2016
Author(s)
Nishiwaki S, Imai K, Mizuta S, Kanamori H, Ohashi K, Fukuda T, Onishi Y, Takahashi S, Uchida N, Eto T, Nakamae H, Yujiri T, Mori S, Nagamura-Inoue T, Suzuki R, Atsuta Y, Tanaka J.
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Journal Title
Bone Marrow Transplantation
Volume: 51
Issue: 1
Pages: 43-50
DOI
Related Report
Peer Reviewed
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[Journal Article] Impacts of graft-versus-host disease on outcomes after allogeneic hematopoietic stem cell transplantation for chronic myelomonocytic leukemia: A nationwide retrospective study.2016
Author(s)
Itonaga H, Iwanaga M, Aoki K, Aoki J, Ishiyama K, Ishikawa T, Sakura T, Fukuda T, Najima Y, Yujiri T, Mori T, Kurokawa M, Nawa Y, Uchida N, Morishita Y, Hashimoto H, Eto T, Hirokawa M, Morishima Y, Nagamura-Inoue T, Atsuta Y, Miyazaki Y.
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Journal Title
Leukemia Research
Volume: 41
Pages: 48-55
DOI
Related Report
Peer Reviewed
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[Journal Article] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.2014
Author(s)
Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T
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Journal Title
Blood Cancer Journal
Volume: 4
Issue: 10
Pages: 252-252
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Significance of TBI/G-CSF-combined high-dose AraC/CY in allogeneic HSCT for myeloid malignancies2016
Author(s)
Nakamura Y., Tanaka Y., Tanaka M., Sugiyama A., Yamamoto K., Matsuguma M., Tokunaga Y., Sasaki T., Nouno S., Yujiri T., Tanizawa T..
Organizer
第78回日本血液学会学術集会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-10-13
Related Report
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[Presentation] A case of intravascular large B-cell lymphoma presenting as refractory autoimmune hemolytic anemia2016
Author(s)
Tanaka M., Nakamura Y., Sasaki T., Hiroshige S., Nomiyama R., Sugiyama A., Kondo M., Tanaka Y., Akiyama M., Takeda K., Yujiri T., Tanizawa Y..
Organizer
第78回日本血液学会学術集会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-10-13
Related Report
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[Presentation] Impact of donor source on allogeneic HSCT outcomes for patients with CMML.2015
Author(s)
Itonaga H., Aoki K., Aoki J., Ishiyama K., Ishikawa T., Uchida N., Hoshino T., Ohashi K., Kurokawa M., Ozawa Y., MatsuokaK., Yujiri T., Hirokawa M., Morishima Y., Kato K., Atsuta Y., Miyazaki Y.
Organizer
第77回日本血液学会学術集会
Place of Presentation
ANAクラウンプラザホテル金沢 (石川県金沢市)
Year and Date
2015-10-16
Related Report
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[Presentation] Impact of PH+ stem cell burden on clinical findings and nilotinib responses in de novo CML-CP.2015
Author(s)
Tsuda M., Nishiwaki K., Sugimoto K., Tamaki S., Hisatake J., Yokoyama H., Igarashi T., Shinagawa A., Sugawara T., Fujikawa K., Hara S., Shimizu S., Yujiri T., Wakita H., Tojo A.
Organizer
第77回日本血液学会学術集会
Place of Presentation
石川県立音楽堂 (石川県金沢市)
Year and Date
2015-10-16
Related Report
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[Presentation] Impact of GVHD on outcome after allogeneic hematopoietic stem cell transplantation for CMML2014
Author(s)
Itonaga H.,Iwanaga M.,Aoki K.,Aoki J.,Ishiyama K.,Kobayashi T.,Sakura T.,Fukuda T.,Yujiri T.,Hirokawa M.,Morishima Y.,Nagamura-Inoue T.,Atsuta Y.,Ishikawa T.,Miyazaki Y.
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2014-10-31 – 2014-11-02
Related Report
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