The study of the prognostic factor search in pediatric acute myeloid leukemia using the next generation sequencing and MLPA method
Project/Area Number |
26461599
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | National Center for Child Health and Development (2015-2016) Gunma Institute of Public Health and Environmental Sciences (2014) |
Principal Investigator |
Ohki Kentaro 国立研究開発法人国立成育医療研究センター, 小児血液・腫瘍研究部, 室長 (50400966)
|
Co-Investigator(Kenkyū-buntansha) |
林 泰秀 群馬県衛生環境研究所, その他部局等, 研究員 (30238133)
朴 明子 群馬県衛生環境研究所, その他部局等, 研究員 (50450375)
外松 学 群馬県衛生環境研究所, その他部局等, 研究員 (70251113)
|
Research Collaborator |
HARA YUSUKE 群馬大学, 小児科
YOSHIDA KENICHI 京都大学
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 遺伝子 / 小児がん / 急性骨髄性白血病 / 次世代シーケンス解析 / MLPA解析 / 次世代シークエンス解析 / 臨床 / 急性骨髄性白血病(AML) / ゲノム / マイクロアレイ / 癌 |
Outline of Final Research Achievements |
Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous disease. In this study, whole-exome sequencing (WES) of 63 pediatric AML patients revealed mutations in components of the cohesin complex (RAD21 and SMC3), BCORL1 and ASXL2 in addition to previously known gene mutations. We also revealed intratumoural heterogeneities in many patients, implicating multiple clonal evolution events in the development of AML. Whole-transcriptome sequencing (WTS) and real-time polymerase chain reaction of pediatric de novo AML patients revealed PRDM16 gene overexpression. The overall survival (OS) and event-free survival (EFS) among PRDM16- overexpressing patients were significantly worse than in patients with low PRDM16 expression (3-year OS: 51% vs. 81%, p<0.001, 3-year EFS: 32% vs. 64%, p <0.001) irrespective of other cytogenetic alterations except for NPM1.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] ZNF384-related fusion genes consist of a subgroup with a characteristic immunophenotype in childhood B-cell precursor acute lymphoblastic leukemia.2017
Author(s)
Hirabayashi S, Ohki K, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, Yaguchi A, Terada K, Saito Y, Yoshimi A, Ogata-Kawata H, Sakamoto H, Kato M, Fujimura J, Hino M, Kinoshita A, Kakuda H, Kurosawa H, Kato K, Kajiwara R, Moriwaki K, Morimoto T, Nakamura K, Noguchi Y, Osumi T, Sakashita K, Takita J, et al.
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Journal Title
Haematologica.
Volume: 102
Issue: 1
Pages: 118-129
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prognostic impact of specific molecular profiles in pediatric acute megakaryoblastic leukemia in non-Down syndrome.2017
Author(s)
Hara Y, Shiba N, Ohki K, Tabuchi K, Yamato G, Park MJ, Tomizawa D, Kinoshita K, Shimada A, Arakawa H, Saito AM, Kiyokawa N, Tawa A, Horibe K, Taga T, Adachi S, Taki T, and Hayashi Y.
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Journal Title
Genes, Chromosomes & Cancer
Volume: 14 February 2017
Issue: 5
Pages: 394-404
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] ASXL2 Mutations are Frequently Found in Pediatric AML Patients with t(8;21)/RUNX1-RUNX1T1 and Associated with a Better Prognosis.2017
Author(s)
Yamato G, Shiba N, Yoshida K, Shiraishi Y, Hara Y, Ohki K, Okubo J, Okuno H, Chiba K, Tanaka H, Kinoshita A, Moritake H, Kiyokawa N, Tomizawa D, Park MJ, Sotomatsu M, Taga T, Adachi S, Tawa A, Horibe K, Arakawa H, Miyano S, Ogawa S, Hayashi Y.
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Journal Title
Genes Chromosomes Cancer.
Volume: -
Issue: 5
Pages: 382-393
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia.2016
Author(s)
Shiba N, Yoshida K, Shiraishi Y, Okuno Y, Yamato G, Hara Y, Nagata Y, Chiba K, Tanaka H, Terui K, Kato M, Park MJ, Ohki K, Shimada A, Takita J, Tomizawa D, Kudo K, Arakawa H, Adachi S, Taga T, Tawa A, Ito E, Horibe K, Sanada M, Miyano S, Ogawa S, Hayashi Y.
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Journal Title
Br J Haematol.
Volume: 175
Issue: 3
Pages: 476-489
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Ph-like ALL-related novel fusion kinase ATF7IP–PDGFRB exhibits high sensitivity to tyrosine kinase inhibitors in murine cells.2016
Author(s)
Takeshi Ishibashi, Akinori Yaguchi, Kazuki Terada, Hitomi Ueno-Yokohata, Osamu Tomita, Kazutoshi Iijima, Kenichiro Kobayashi, Hajime Okita, Junya Fujimura, Kentaro Ohki, Toshiaki Shimizu, Nobutaka Kiyokawa.
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Journal Title
Experimental Hematology.
Volume: 44
Issue: 3
Pages: 177-188
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3-ITD, KMT2A-PTD, and NUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial.2015
Author(s)
Shiba N, Ohki K, Kobayashi T, Hara Y, Yamato G, Tanoshima R, Ichikawa H, Tomizawa D, Park MJ, Shimada A, Sotomatsu M, Arakawa H, Horibe K, Adachi S, Taga T, Tawa A, Hayashi Y.
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Journal Title
Br J Haematol.
Volume: 172
Issue: 4
Pages: 581-91
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
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[Journal Article] High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML.2015
Author(s)
Jo A, Mitani S, Shiba N, Hayashi Y, Hara Y, Takahashi H, Tsukimoto I, Tawa A, Horibe K, Tomizawa D, Taga T, Adachi S, Yoshida T, Ichikawa H
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Journal Title
Leukemia
Volume: 29
Issue: 5
Pages: 1067-1083
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial.2015
Author(s)
Tokumasu M, Murata C, Shimada A, Ohki K, Hayashi Y, Saito AM, Fujimoto J, Horibe K, Nagao M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Tomizawa D, Taga T, Tawa A, Tanaka S, Heike T, Adachi S
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Journal Title
Leukemia
Volume: 29
Issue: 12
Pages: 2438-2441
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia.2015
Author(s)
Koh K, Tomizawa D, Moriya Saito A, Watanabe T, Miyamura T, Hirayama M, Takahashi Y, Ogawa A, Kato K, Sugita K, Sato T, Deguchi T, Hayashi Y, Takita J, Takeshita Y, Tsurusawa M, Horibe K, Mizutani S, Ishii E.
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Journal Title
Leukemia
Volume: 29(2)
Issue: 2
Pages: 290-6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 小児Ph-like ALL症例の表面マーカー、遺伝子発現解析.2014
Author(s)
飯島 一智, 清河 信敬, 吉原 宏樹, 富田 理, 小林 健一郎, 福島 敬, 林 泰秀, 菊地 陽, 康 勝好, 真部 淳, 小原 明.
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Journal Title
日本小児血液・がん学会雑誌
Volume: 51
Pages: 200-205
Related Report
Peer Reviewed
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[Journal Article] Gene alterations involving the CRLF2-JAK pathway and recurrent gene deletions in Down syndrome-associated acute lymphoblastic leukemia in Japan.2014
Author(s)
Hanada I, Terui K, Ikeda F, Toki T, Kanezaki R, Sato T, Kamio T, Kudo K, Sasaki S, Takahashi Y, Hayashi Y, Inukai T, Kojima S, Koike K, Kosaka Y, Kobayashi M, Imaizumi M, Mitsui T, Hori H, Hara J, Horibe K, Nagai J, Goto H, Ito E.
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Journal Title
Genes Chromosomes Cancer
Volume: 53
Issue: 11
Pages: 902-910
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic impact of gained chromosomes in high-hyperdiploid childhood acute lymphoblastic leukaemia2014
Author(s)
Kato M, Imamura T, Manabe A, Hashii Y, Koh K, Sato A, Takahashi H, Hori H, Taki T, Inoue M, Hayashi Y, Horibe K, Tsuchida M, Kojima S, Oda M, Ohara A .
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Journal Title
Br J Haematol
Volume: 166
Issue: 2
Pages: 295-298
DOI
Related Report
Peer Reviewed
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[Journal Article] Acute myeloid leukaemia with myelodysplastic features in children2014
Author(s)
Kinoshita A, Miyachi H, Matsushita H, Yabe M, Taki T, Watanabe T, Saito AM, Tomizawa D, Taga T, Takahashi H, Matsuo H, Kodama K, Ohki K, Hayashi Y, Tawa A, Horibe K, Adachi S.
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Journal Title
Br J Haematol
Volume: 167
Issue: 1
Pages: 80-86
DOI
Related Report
Peer Reviewed
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[Journal Article] Significance of CD66c expression in childhood acute lymphoblastic leukemia.2014
Author(s)
Kiyokawa N, Iijima K, Tomita O, Miharu M, Hasegawa D, Kobayashi K, Okita H, Kajiwara M, Shimada H, Inukai T, Makimoto A, Fukushima T, Nanmoku T, Koh K, Manabe A, Kikuchi A, Sugita K, Fujimoto J, Hayashi Y, Ohara A.
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Journal Title
Leuk Res.
Volume: 38
Issue: 1
Pages: 42-8
DOI
Related Report
Peer Reviewed
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[Journal Article] EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia.2014
Author(s)
Matsuo H, Kajihara M, Tomizawa D, Watanabe T, Saito AM, Fujimoto J, Horibe K, Kodama K, Tokumasu M, Itoh H, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Shiba N, Ohki K, Hayashi Y, Yamashita Y, Shimada A, Tanaka S, Adachi S.
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Journal Title
Haematologica
Volume: 99
Issue: 11
Pages: 225-227
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mutations of the GATA2 and CEBPA genes in paediatric acute myeloid leukaemia.2014
Author(s)
Shiba N, Funato M, Ohki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
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Journal Title
Brit J Haematol
Volume: 印刷中
Issue: 1
Pages: 142-159
DOI
Related Report
Peer Reviewed
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[Journal Article] Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays2014
Author(s)
Takita J, Chen Y, Kato M, Ohki K, Sato Y, Ohta S, Sugita K, Nishimura R, Hoshino N, Seki M, Sanada M, Oka A, Hayashi Y, Ogawa S
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Journal Title
Cancer Sci
Volume: 105
Issue: 3
Pages: 258-64
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Incidence and clinical relevance of MEF2D- and ZNF384-relattsuyoshied fusion genes in childhood B-cell precursor acute lymphoblastic leukemia: TCCSG L0416/0616 study2016
Author(s)
大木健太郎, 平林真介, 加藤元博, 中林一彦, 秦健一郎, 梶原良介, 高橋浩之, 福島敬, 康勝好, 真部淳, 小原明, 清河信敬.
Organizer
第58回日本小児血液・がん学会学術集会
Place of Presentation
東京
Year and Date
2016-12-15
Related Report
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[Presentation] Frequency and clinical features of RUNX1 mutations in pediatric acute myeloid leukemia patients.2016
Author(s)
大和玄季, 柴徳生, 吉田健一, 原勇介, 大木健太郎, 大久保淳, 朴明子, 外松学, 清河信敬, 富澤大輔, 多賀崇, 足立壮一, 多和昭雄, 堀部敬三, 荒川浩一, 小川誠司, 林泰秀
Organizer
第58回日本小児血液・がん学会学術集会
Place of Presentation
東京
Year and Date
2016-12-15
Related Report
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[Presentation] Novel risk stratification of infant acute myeloid leukemia using MLL-rearrangements and CBFA2T3-GLIS2.2016
Author(s)
原勇介, 柴徳生, 大木健太郎, 大和玄季, 朴明子, 富澤大輔, 滝智彦, 木下明俊, 清河信敬, 荒川浩一, 多和昭雄, 堀部敬三, 多賀崇, 足立壮一, 林泰秀
Organizer
第58回日本小児血液・がん学会学術集会
Place of Presentation
東京
Year and Date
2016-12-15
Related Report
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[Presentation] Genetic Abnormalities and Prognosis in Pediatric B-precursor Acute Lymphoblastic Leukemia without conventional genetic abnormalities; Tokyo Children’s Cancer Study Group.2016
Author(s)
Ohki K, Hirabayashi S, Yaguchi A, Terada K, Ohkubo J, Shiba N, Kato M, Fukushima T, Koh K, Hayashi Y, Manabe A, Ohara A, Kiyokawa N.
Organizer
58th ASH Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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[Presentation] Retrospective Evaluation of Correlations Between Genetic Backgrounds and Stem Cell Transplantation for De Novo Pediatric Acute Myeloid Leukemia: A Study from the Japan Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 Clinical Trial.2016
Author(s)
Ueno T, Yamato G, Shiba N, Hara Y, Ohki K, Ichikawa H, Park MJ, Shimada A, Sotomatsu M, Arakawa H, Horibe K, Adachi S, Taga T, Tawa A, Hayashi Y.
Organizer
58th ASH Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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[Presentation] Identification of Two Distinct Poor Prognostic Subgroups Related to High Expression of BMP2 or PRDM16 in Pediatric AML.2016
Author(s)
Hara Y, Shiba N, Yamato G, Okubo J, Ohki K, Park MJ, Sotomatsu M, Tomizawa D, Taki T, Kinoshita A, Kiyokawa N, Taga T, Arakawa H, Tawa A, Horibe K, Adachi S, Hayashi Y.
Organizer
58th ASH Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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[Presentation] The Clinical Features and Prognostic Impact of PRDM16 gene Expression in Adult Acute Myeloid Leukemia.2016
Author(s)
Yamato G, Yamaguchi H, Handa H, Shiba N, Wakita S, Inokuchi K, Hara Y, Ohki K, Okubo J, Sotomatsu M, Arakawa H, Hayashi Y.
Organizer
58th ASH Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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[Presentation] Transcriptome Analysis Revealed the Entire Genetic Understanding of Pediatric Acute Myeloid Leukemia with a Normal Karyotype.2016
Author(s)
Shiba N, Yashida K, Shiraishi Y, Hara Y, Yamato G, Kaburagi T, Sanada M, Ohki K, Park MJ, Tomizawa D, Chiba K, Tanaka H, Sotomatsu M, Arakawa H, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y.
Organizer
58th ASH Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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[Presentation] Transcriptome analysis of 92 pediatric acute myeloid leukemia patients.2016
Author(s)
Norio Shiba, Kenichi Yoshida, Genki Yamato, Yusuke Hara, Masashi Sanada, Yuichi Shiraishi, Kentaro Ohki, Myoug-Ja Park, Taeko Kaburaki, Daisuke Tomizawa, Manabu Sotomatsu, Hirokazu Arakawa, Keizo Horibe, Takashi Taga, Souichi Adachi, Akio Tawa, Satoru Miyano, Seishi Ogawa, Yasuhida Hayashi
Organizer
The 78th Annual Meeting of the Japanese Society of Hematology
Place of Presentation
横浜
Year and Date
2016-10-13
Related Report
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[Presentation] Molecular features and their clinical impact in infant acute myeloid leukemia2016
Author(s)
Yusuke Hara, Norio Shiba, Kentaro Ohki, Genki Yamato, Myoug-Ja Park, Daisuke Tomizawa, Tomohiko Taki, Akitoshi Kinoshita, Hirokazu Arakawa, Akio Tawa, Keizo Horibe, Takashi Taga, Souichi Adachi, Yasuhide Hayashi
Organizer
The 78th Annual Meeting of the Japanese Society of Hematology
Place of Presentation
横浜
Year and Date
2016-10-13
Related Report
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[Presentation] Clinical features of patients with ASXL1 and ASXL2 mutations in pediatric acute myeloid leukemia2016
Author(s)
Genki Yamato, Norio Shiba, Kenichi Yoshida, Kentaro Ohki, Jun Okubo, Yusuke Hara, Akitoshi Kinoshita, Daisuke Tomizawa, Manabu Sotomatsu, Takashi Taga, Souichi Adachi, Akio Tawa, Keizo Horibe, Hirokazu Arakawa, Seishi Ogawa, Yasuhida Hayashi
Organizer
The 78th Annual Meeting of the Japanese Society of Hematology
Place of Presentation
横浜
Year and Date
2016-10-13
Related Report
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[Presentation] A Combination of EVI1 and PRDM16 Expression Clarified the Clinical Features of Intermediate/High Risk Patients in Pediatric Acute Myeloid Leukemia.2015
Author(s)
Yamato G, Shiba N, Hara Y, Park M, Sotomatsu M, Ohki K, Ichikawa H, Tomizawa D, Taga T, Horibe K, Tawa A, Arakawa H, Adachi S, Hayashi Y.
Organizer
57th ASH Annual Meeting and Exposition
Place of Presentation
Orland
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] Detection of Novel Pathogenic Gene Rearrangements in Pediatric Acute Myeloid Leukemia By RNA Sequencing.2015
Author(s)
Shiba N, Yoshida K, Shiraishi Y, Hara Y, Yamato G, Kaburaki T, Sanada M, Oki K, Tomizawa D, Sotomatsu M, Arakawa H, Horibe K, Park M, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y
Organizer
57th ASH Annual Meeting and Exposition
Place of Presentation
Orland
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] RNA seqにより見いだされた新規遺伝子の解析と臨床像.2015
Author(s)
原 勇介, 柴 徳生, 大和 玄季, 大木 健太郎, 朴 明子, 外松 学, 滝 智彦, 吉田 健一, 眞田 昌, 富澤 大輔, 荒川 浩一, 堀部 敬三, 多賀 崇, 足立 壮一, 多和 昭雄, 宮野 悟, 小川 誠司, 林 泰秀
Organizer
第57回日本小児血液・がん学会学術総会
Place of Presentation
甲府
Year and Date
2015-11-27
Related Report
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[Presentation] 小児急性骨髄性白血病におけるPRDM16遺伝子とEVI1遺伝子発現の臨床的意義.2015
Author(s)
大和 玄季, 柴 徳生, 原 勇介, 朴 明子, 外松 学, 大木 健太郎, 市川 仁, 富澤 大輔, 多賀 崇, 堀部 敬三, 多和 昭雄, 荒川 浩一, 足立 壮一, 林 泰秀.
Organizer
第57回日本小児血液・がん学会学術総会
Place of Presentation
甲府
Year and Date
2015-11-27
Related Report
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[Presentation] The prognostic impact of PRDM16 gene expression in both adult and pediatric acute myeloid leukemia.2015
Author(s)
Yamato G, Yamaguchi H, Handa H, Shiba N, Wakita S, Inokuchi K, Hara Y, Ohki K, Park M, Sotomatsu M, Ichikawa H, Tomizawa D, Taga T, Adachi S, Horibe K, Tawa A, Arakawa H, Hayashi Y.
Organizer
第77回日本血液学会学術総会
Place of Presentation
金沢
Year and Date
2015-10-16
Related Report
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[Presentation] RNA sequencing reveals the comprehensive gene alterations of pediatric acute myeloid leukemia.2015
Author(s)
Shiba N, Yoshida K, Sanada M, Shiraishi Y, Hara Y, Yamato G, Ohki K, Park M, Tomizawa D, Sotomatsu M, Arakawa H, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y.
Organizer
第77回日本血液学会学術総会
Place of Presentation
金沢
Year and Date
2015-10-16
Related Report
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[Presentation] 中間リスク、高リスク小児急性骨髄性白血病における新たな治療層別化の試み2015
Author(s)
柴 徳生, 原 勇介, 大木 健太郎, 大和 玄季, 富澤 大輔, 多賀 崇, 多和 昭雄, 荒川 浩一, 足立 壮一, 林 泰秀, JPLSG AML委員会
Organizer
第118回日本小児科学会
Place of Presentation
大阪
Year and Date
2015-04-17
Related Report
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[Presentation] Differentiating Burkitt Lymphoma from Burkitt-like Lymphoma in Pediatrics: Report from the Japanese Pediatric Leukemia/Lymphoma Study Group B-NHL03 Study.2014
Author(s)
Osumi T, Sekimizu M, Mori T, Fukano R, Koga Y, Ueyama J, Tanaka F, Ohki K, Mitsui T, Mori T, Sunami S, Kada A, Moriya Saito A, Horibe K, Koh K, Komada Y, Kosaka Y, Ohshima K, Nakazawa A, Tsurusawa M, Kobayashi R, Adachi S.
Organizer
56th ASH Annual Meeting and Exposition
Place of Presentation
San Francisco
Year and Date
2014-12-06 – 2014-12-09
Related Report
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[Presentation] The Prognostic Impact of High MEL1 Gene Expression in Pediatric Acute Myeloid Leukemia.2014
Author(s)
Shiba N, Ohki K, Hara Y, Yamato G, Park M, Ichikawa H, Kobayashi T, Tomizawa D, Sotomatsu M, Arakawa H, Horibe K, Taga T, Adachi S, Tawa A, Hayashi Y.
Organizer
56th ASH Annual Meeting and Exposition
Place of Presentation
San Francisco
Year and Date
2014-12-06 – 2014-12-09
Related Report
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[Presentation] Poor Prognosis Associated with FAB Subtypes M4 and M5 in Japanese Pediatric Acute Myeloid Leukemia Patients with FLT3-ITD.2014
Author(s)
Hara Y, Shiba N, Ohki K, Park M, Shimada A, Tomizawa D, Moriya Saito M, Fujimoto J, Taki T, Kinoshita A, Taga T, Arakawa H, Tawa A, Horibe K, Adachi S, Hayashi Y.
Organizer
56th ASH Annual Meeting and Exposition
Place of Presentation
San Francisco
Year and Date
2014-12-06 – 2014-12-09
Related Report
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[Presentation] Clinical Features of Patients with ASXL1 and ASXL2 Mutations in Pediatric Acute Myeloid Leukemia.2014
Author(s)
Yamato G, Shiba N, Yoshida K, Ohki K, Park M, Hara Y, Tomizawa D, Sotomatsu M, Taga T, Adachi S, Tawa A, Horibe K, Arakawa H, Ogawa S, Hayashi Y.
Organizer
56th ASH Annual Meeting and Exposition
Place of Presentation
San Francisco
Year and Date
2014-12-06 – 2014-12-09
Related Report
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[Presentation] Whole Exome and Transcriptome Analyses in Pediatric T-Cell Acute Lymphoblastic Leukemia.2014
Author(s)
Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Kato M, Hanada R, Miyano S, Hayashi Y, Ogawa S, Takita J.
Organizer
56th ASH Annual Meeting and Exposition
Place of Presentation
San Francisco
Year and Date
2014-12-06 – 2014-12-09
Related Report
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[Presentation] 小児AMLにおけるIKZF1欠失の頻度と予後解析 JPLSG AML-052014
Author(s)
大木 健太郎, 朴 明子, 原 勇介, 柴 徳生, 外松 学, 富澤 大輔, 多賀 崇, 齋藤 明子, 藤本 純一郎, 多和 昭雄, 堀部 敬三, 足立 壮一, 林 泰秀.
Organizer
第56回日本小児血液・がん学会学術集会
Place of Presentation
岡山
Year and Date
2014-11-28 – 2014-11-30
Related Report
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[Presentation] 小児急性骨髄性白血病におけるASXL1、ASXL2遺伝子変異と臨床像2014
Author(s)
大和 玄季, 柴 徳生, 吉田 健一, 大木 健太郎, 朴 明子, 原 勇介, 外松 学, 多賀 崇, 富澤 大輔, 足立 壮一, 多和 昭雄, 堀部 敬三, 荒川 浩一, 小川 誠司, 林 泰秀.
Organizer
第56回日本小児血液・がん学会学術集会
Place of Presentation
岡山
Year and Date
2014-11-28 – 2014-11-30
Related Report
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[Presentation] Gene expression and DNA methylation related to prognosis of childhood ALL without fusion genes.2014
Author(s)
Iijima K, Kiyokawa N, Ueno H, Yoshihara H, Hasegawa D, Ohki K, Kato M, Fukushima T, Koh K, Hayashi Y, Manabe A, Ohara A.
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] Analysis of iAMP21 and ERG genes in pediatric B-precursor ALL trated on TCCSG protocol..2014
Author(s)
Ohki K, Ohkita H, Kobayashi K, Shiba N, Park M, Sotomatsu M, Fukushima T, Koh K, Hanada R, Manabe A, Kikuchi A, Tsutida M, Ohara A, Kiyokawa N, Hayashi Y.
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] CSF3R and CALR mutations and cytogenetic findings in pediatric myeloid malignancies.2014
Author(s)
Sano H, Ohki K, Park M, Shiba N, Hara Y, Sotomatsu M, Tomizawa D, Taga T, Kiyokawa N, Tawa A, Horibe K, Adachi A, Hayashi Y.
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] The prognostic impact of high EV1-related genes expression in pediatric acute myeloid leukemia.2014
Author(s)
Shiba N, Hara Y, Ohki K, Yamato G, Park M, Kobayashi T, Ichikawa H, Tomizawa D, Taki T, Shimada A, Sotomatsu M, Arakawa H, Horibe H, Adachi S, Tawa A, Hayashi Y. The prognostic impact of high EV1-related genes expression in pediatric acute myeloid leukemia.
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] 小児急性骨髄性白血病におけるGATA2変異の解析.2014
Author(s)
原 勇介, 柴 徳生, 大木 健太郎, 朴 明子, 足立 壮一, 多賀 崇, 荒川 浩一, 多和 昭雄, 堀部 敬三, 林 泰秀.
Organizer
第117回日本小児科学会学術集会
Place of Presentation
名古屋
Year and Date
2014-04-11 – 2014-04-13
Related Report
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[Presentation] 小児急性骨髄性白血病における分子生物学的背景を用いた新たな治療層別化への試み.2014
Author(s)
柴 徳生, 吉田 健一, 大木 健太郎, 金澤 崇, 足立 壮一, 多和 昭雄, 伊藤 悦朗, 荒川 浩一, 小川 誠司, 林 泰秀, JPLSG AML委員会.
Organizer
第117回日本小児科学会学術集会
Place of Presentation
名古屋
Year and Date
2014-04-11 – 2014-04-13
Related Report
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