Journal of Biological Chemistry
Glycobiology and Extracellular MatricesChondroitin sulfate–mediated N-cadherin/β-catenin signaling is associated with basal-like breast cancer cell invasion
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This work was supported in part by Grants-in-aid for Scientific Research on Innovative Areas 23110003 (to H. K.), Scientific Research (B) 16H05088 (to H. K.), and (C) 25460080 (to S. N.), and the Supported Program for the Strategic Research Foundation at Private Universities, 2012–2016 (to H. K.), from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. The authors declare that they have no conflicts of interest with the contents of this article.
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The abbreviations used are:
- ER
estrogen receptor
- PR
progesterone receptor
- ADAM
disintegrin and metalloprotease
- CS
chondroitin sulfate
- EC
extracellular cadherin
- ECM
extracellular matrix
- GalNAc4S-6ST
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
- MMP
matrix metalloprotease
- N-Cad(C)
C-terminal of N-cadherin
- PG
proteoglycan
- EGFP
enhanced green fluorescent protein
- Chn
chondroitin
- TCF
T cell factor
- LEF
lymphoid enhancer factor
- N-Cad(FL)
full-length N-cadherin
- SDC
syndecan
- CTF
C-terminal fragment
- Pcdh
protocadherin
- gRNA
guide RNA
- SPR
lymphoid enhancer factor
- HS
heparan sulfate.