Diagnostic value of tumor metabolites in metabolome analysis for glioma patients
Project/Area Number |
25293309
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Kobe University |
Principal Investigator |
Kohmura Eiji 神戸大学, 医学(系)研究科(研究院), 教授 (30225388)
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Co-Investigator(Kenkyū-buntansha) |
SASAYAMA Takashi 神戸大学, 医学部附属病院, 講師 (10379399)
TANAKA Kazuhiro 神戸大学, 医学(系)研究科(研究院), 研究員 (70467661)
HOSODA Koukichi 神戸大学, 医学(系)研究科(研究院), 准教授 (90403261)
MIZUKAWA Katsu 神戸大学, 医学部附属病院, 助教 (80403260)
SASAKI Ryohei 神戸大学, 医学部附属病院, 教授 (30346267)
西原 賢在 神戸大学, 医学(系)研究科(研究院), 研究員 (20452493)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
Keywords | glioma / metabolome / IDH / glutamate / IDH mutation / 2-hydroxyglutarate / MR spectroscopy / グリオーマ / メタボローム解析 |
Outline of Final Research Achievements |
In this study, we aimed to determine the additional value of other metabolites in predicting IDH1 mutations with conventional MRS. RESULTS: A metabolomic analysis demonstrated higher levels of 2HG in IDH1 mutant glioma cells and surgical tissues. Interestingly, glutamate levels were significantly decreased in IDH1 mutant gliomas. Through an analysis of metabolic enzyme genes in glutamine pathways, it was shown that the expressions of branched-chain amino acid transaminase 1 were reduced and glutamate dehydrogenase levels were elevated in IDH1 mutant gliomas. Conventional MRS detection of glutamate and 2HG resulted in a high diagnostic accuracy (sensitivity 72%, specificity 96%) for IDH1 mutant glioma. CONCLUSIONS: IDH1 mutations alter glutamate metabolism. Combining glutamate levels optimizes the 2HG-based monitoring of IDH1 mutations via MRS and represents a reliable clinical application for diagnosing IDH1 mutant gliomas.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma2016
Author(s)
Hiroaki Nagashima1, Kazuhiro Tanaka1*, Takashi Sasayama1, Yasuhiro Irino2, Naoko Sato1, Yukiko Takeuchi2, Katsusuke Kyotani3, Akitake Mukasa6, Katsu Mizukawa1, Junichi Sakata1, Yusuke Yamamoto1, Kohkichi Hosoda1, Tomoo Itoh4, Ryohei Sasaki5, and Eiji Kohmura1
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Journal Title
Neuro-Oncology
Volume: in press
Pages: 1-10
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Radiographic occult cerebellar germinoma presenting with progressive ataxia and cranial nerve palsy.2016
Author(s)
Minami N, Tanaka K, Kimura H, Hirose T, Mori T, Maeyama M, Sekiya H, Uenaka T, Nakamizo S, Nagashima H, Mizukawa K, Itoh T, Sasayama T, Kohmura E.
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Journal Title
BMC Neurol.
Volume: 16
Issue: 1
Pages: 1-4
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review.2016
Author(s)
Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
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Journal Title
Asia Pac J Clin Oncol.
Volume: Mar 3
Issue: 2
Pages: 1-8
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Two Cases of Cerebral Infarction due to Focal Irradiation for Glioma in Adults2015
Author(s)
Minami N, Mizukawa K, Iwahashi H, Nagashima H, Tanaka K, Sasayama T, Hosoda K, Mukumoto N, Sasaki R, Kohmura E.
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Journal Title
Neurological Surgery 脳神経外科
Volume: 43
Issue: 4
Pages: 344-351
DOI
ISSN
0301-2603, 1882-1251
Year and Date
2015-04-10
Related Report
Peer Reviewed
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[Journal Article] Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.2015
Author(s)
Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.
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Journal Title
J Clin Invest
Volume: 125
Issue: 4
Pages: 1591-602
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma.2015
Author(s)
Mizowaki T, Sasayama T, Tanaka K, Mizukawa K, Takata K, Nakamizo S, Tanaka H, Nagashima H, Nishihara M, Hirose T, Itoh T, Kohmura E
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Journal Title
J Neurooncol
Volume: 124(2)
Issue: 2
Pages: 165-74
DOI
Related Report
Peer Reviewed
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[Journal Article] Combined IDH1 mutation and MGMT methylation status on long-term survival of patients with cerebral low-grade glioma.2015
Author(s)
Tanaka K, Sasayama T, Mizukawa K, Takata K, Sulaiman NS, Nishihara M, Kohta M, Sasaki R, Hirose T, Itoh T, Kohmura E.
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Journal Title
Clin Neurol Neurosurg.
Volume: 138
Pages: 37-44
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tumor-Associated Macrophages Associate with Cerebrospinal Fluid Interleukin-10 and Survival in Primary Central Nervous System Lymphoma (PCNSL)2015
Author(s)
Sasayama T, Tanaka K, Mizowaki T, Nagashima H, Nakamizo S, Tanaka H, Nishihara M, Mizukawa K, Hirose T, Itoh T, Kohmura E
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Journal Title
Brain Pathol.
Volume: Aug 28
Issue: 4
Pages: 1-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Cilostazol administration with combination enteral and parenteral nutrition therapy remarkably improves outcome after subarachnoid hemorrhage2015
Author(s)
Kimura H, Okamura Y, Chiba Y, Shigeru M, Ishii T, Hori T, Shiomi R, Yamamoto Y, Fujimoto Y, Maeyama M, Kohmura E.
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Journal Title
Acta Neurochir Suppl
Volume: 120
Pages: 147-52
DOI
ISBN
9783319049809, 9783319049816
Related Report
Peer Reviewed
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[Journal Article] 2.Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis.2014
Author(s)
Kinoshita M1, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
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Journal Title
Neuro Oncol
Volume: 16
Issue: 5
Pages: 728-734
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Utility of 320- detector row ct for diagnosis and therapeutic strategy for paraclinoid and intracavernous aneurysms.2014
Author(s)
Inoue, S., Hosoda, K., Fujita, A., Ohno, Y., Fujii, M., Sugimura, K., and Kohmura, E.
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Journal Title
Acta Neurochir (Wien)
Volume: 156
Issue: 3
Pages: 505-514
DOI
Related Report
Peer Reviewed
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[Journal Article]2013
Author(s)
Nakamizo S, Sasayama T, Shinohara M, Irino Y, Nishiumi S, Nishihara M, Tanaka H, Tanaka K, Mizukawa K, Itoh T, Taniguchi M, Hosoda K, Yoshida M, Kohmura E
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Journal Title
J Neurooncol
Volume: 113(1)
Issue: 1
Pages: 65-74
DOI
Related Report
Peer Reviewed
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[Journal Article]2013
Author(s)
Tanaka H, Sasayama T, Tanaka K, Nakamizo S, Nishihara M, Mizukawa K, Kohta M, Koyama J, Miyake S, Taniguchi M, Hosoda K, Kohmura E
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Journal Title
J Neurooncol
Volume: 111(3)
Issue: 3
Pages: 273-83
DOI
Related Report
Peer Reviewed
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[Journal Article]2013
Author(s)
Taniguchi M, Nishihara M, Sasayama T, Takahashi Y, Kohmura E
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Journal Title
Neuropathol Appl Neurobiol
Volume: 39(4)
Issue: 4
Pages: 445-8
DOI
Related Report
Peer Reviewed
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[Journal Article]2013
Author(s)
Ishii T, Mizukawa K, Sasayama T, Sasaki H, Hayashi S, Nakamizo S, Tanaka H, Tanaka K, Hara S, Hirai C, Itoh T, Kohmura E
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Journal Title
Neuropathology
Volume: 33(3)
Issue: 3
Pages: 299-305
DOI
Related Report
Peer Reviewed
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[Journal Article] Severe inhibitor-negative acquired factorXIII/13 deficiency with aggressivesubdural haemorrhage2013
Author(s)
Kawano H, Yamamoto D, Uchihashi Y, Wakahashi K, Kawano Y, Sada A, Minagawa K, Katayama Y, Kohmura E,Souri M, Ichinose A.
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Journal Title
Blood Coagul Fibrinolysis
Volume: (印刷中)
Issue: 6
Pages: 638-41
DOI
Related Report
Peer Reviewed
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