Development of novel therapy based on functional reorganization in brain tumor patients
Project/Area Number |
25462247
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
福多 真史 新潟大学, 脳研究所, 非常勤講師 (00361907)
中田 力 新潟大学, 脳研究所, 特任教授 (50281720)
|
Co-Investigator(Renkei-kenkyūsha) |
MATSUZAWA Hitoshi 新潟大学, 脳研究所, 准教授 (70303170)
HIRAISHI Tetsuya 新潟大学, 脳研究所, 助教 (80515734)
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Research Collaborator |
AOKI Hiroshi
KURABE Satoshi
TSUKAMOTO Yoshihiro
|
Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脳腫瘍 / 脳機能再構築 / fMRI / NIRS / 新規治療 / 機能的再構築 / TMS / 新規治療法 |
Outline of Final Research Achievements |
Motor functions in brain tumor patients were assessed by fMRI. The locus of primary sensory motor activation during contralesional hand grasp was displaced by the tumor, suggesting functional compromise and/or reorganization in the central sulcus region. Their contralesional cerebellum activation during contralesional hand grasp was also increased as compared to normal subjects, representing the first evidence that the cerebellum is involved in the functional reorganization in brain tumor patients. Intraoperative language functions were studied using NIRS. Cortical stimulation of Broca’s area elicits hemodynamic responses of NIRS in Wernicke’s area via cortico-cortical connectivity, demonstrating visualization of cortico-cortical evoked responses in language systems. These results can contribute to understand the mechanism for functional reorganization in brain tumor patients and provide important information on developing new therapy for brain tumors based on reorganization.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Efficacy and safety of non-suture dural closure using a novel dural substitute consisting of polyglycolic acid felt and fibrin glue to prevent cerebrospinal fluid leakage-A non-controlled, open-label, multicenter clinical trial.2017
Author(s)
Terasaka S, Taoka T, Kuroda S, Mikuni N, Nishi T, Nakase H, Fujii Y, Hayashi Y, Murata JI, Kikuta KI, Kuroiwa T, Shimokawa S, Houkin K.
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Journal Title
J Mater Sci Mater Med
Volume: 28
Issue: 5
Pages: 69-69
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Long-term survivors of primary central nervous system lymphoma.2017
Author(s)
Yamanaka R, Morii K, Sano M, Homma J, Yajima N, Tsukamoto Y, Ogura R, Natsumeda M, Aoki H, Akiyama K, Saitoh T, Hondoh H, Kawaguchi A, Takahashi H, Fujii Y.
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Journal Title
Jpn J Clin Oncol
Volume: 47
Issue: 2
Pages: 101-107
DOI
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[Journal Article] Late relapse of primary central nervous system lymphoma.2017
Author(s)
Yamanaka R, Morii K, Shinbo Y, Sano M, Homma J, Tsuchiya N, Yajima N, Tsukamoto Y, Ogura R, Natsumeda M, Aoki H, Akiyama K, Saitoh T, Tamura T, Hondoh H, Kawaguchi A, Takahashi H, Fujii Y.
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Journal Title
Leuk Lymphoma
Volume: 58
Pages: 475-477
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Peer Reviewed
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[Journal Article] Aquaporin PET differentiates between grade III and IV human astrocytoma.2017
Author(s)
Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H, Kitaura H, Kakita A, Fujii Y, Huber VJ, Igarashi H, Kwee IL, Nakada T
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[Journal Article] Chemical screening identifies EUrd as a novel inhibitor against Temozolomide-resistant glioblastoma-initiating cells.2016
Author(s)
Tsukamoto Y, Ohtsu N, Echizenya S, Otsuguro S, Ogura R, Natsumeda M, Isogawa M, Aoki H, Ichikawa S, Sakaitani M, Matsuda A, Maenaka K, Fujii Y, Kondo T.
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Journal Title
Stem Cells
Volume: -
Issue: 8
Pages: 2016-2025
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[Journal Article] Determining the presence of thin-walled Regions at high-pressure areas in unruptured cerebral aneurysms by using computational fluid dynamics.2016
Author(s)
Suzuki T, Takao H, Suzuki T, Kambayashi Y, Watanabe M, Sakamoto H, Kan I, Nishimura K, Kaku S, Ishibashi T, Ikeuchi S, Yamamoto M, Fujii Y, Murayama Y..
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Journal Title
Neurosurgery
Volume: 79
Issue: 4
Pages: 589-595
DOI
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Peer Reviewed
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[Journal Article] Determining the presence of thin-walled Regions at high-pressure areas in unruptured cerebral aneurysms by using computational fluid dynamics.2016
Author(s)
Suzuki T, Takao H, Suzuki T, Kambayashi Y, Watanabe M, Sakamoto H, Kan I, Nishimura K, Kaku S, Ishibashi T, Ikeuchi S, Yamamoto M, Fujii Y, Murayama Y.
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[Journal Article] Application of Brain Diffusion-Weighted Imaging Performed Using Readout Segmentation of Long Variable Echo Trains2015
Author(s)
石田 剛, 大石 誠, 森井 研, 長谷川顕士, 斉藤明彦. 佐藤光弥, 滝沢 修, 村田勝俊, Porter DA, 松澤 等, 藤井幸彦.
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Journal Title
Neurological Surgery 脳神経外科
Volume: 43
Issue: 1
Pages: 31-40
DOI
ISSN
0301-2603, 1882-1251
Year and Date
2015-01-10
Related Report
Peer Reviewed
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[Journal Article] Fluid structure interaction analysis reveals facial nerve palsy caused by vertebral-posterior inferior cerebellar artery aneurysm.2015
Author(s)
Suzuki T, Takao H, Suzuki T, Kambayashi Y, Watanabe M, Shinohara S, Fujiwara H, Nakazato S, Watanabe M, Dahmani C, Yamamoto M, Fujii Y, Murayama Y.
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Journal Title
Comput Biol Med
Volume: 66
Pages: 263-268
DOI
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[Journal Article] Immunohistochemical profiles of IDH1, MGMT and p53: Practical significance for prognostication of patients with diffuse gliomas.2015
Author(s)
Ogura R, Tsukamoto Y, Natsumeda M, Isogawa M, Aoki H, Kobayashi T, Yoshida S, Okamoto K, Takahashi H, Fujii Y, Kakita A.
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Journal Title
Neuropathology
Volume: -
Issue: 4
Pages: 324-335
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[Journal Article] Treatment outcomes in glioblastoma patients aged 76 years or older: a multicenter retrospective cohort study.2014
Author(s)
Uzuka T, Asano K, Sasajima T, Sakurada K, Kumabe T, Beppu T, Ichikawa M, Kitanaka C, Aoki H, Saito K, Ogasawara K, Tominaga T, Mizoi K, Ohkuma H, Fujii Y, Kayama T; Tohoku Brain Tumor Study Group.
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Journal Title
J Neurooncol
Volume: 116
Issue: 2
Pages: 299-306
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[Journal Article] Epstein-Barr virus-associated primary central nervous system cytotoxic T-cell lymphoma.2013
Author(s)
Ogura R, Aoki H, Natsumeda M, Shimizu H, Kobayashi T, Saito T, Takizawa J, Okamoto K, Hasegawa G, Umezu H, Ohshima K, Takahashi H, Fujii Y, Kakita A.
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Journal Title
Neuropathology
Volume: 33
Issue: 4
Pages: 436-441
DOI
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