In vivo MR imaging of microglia in glioblastoma
Project/Area Number |
25462256
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
Principal Investigator |
KINOSHITA MANABU 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 脳神経外科, 医長 (40448064)
|
Co-Investigator(Kenkyū-buntansha) |
YOSHIOKA Yoshichika 大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤) (00174897)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | MRI / 膠芽腫 / 細胞浸潤 / in vivo イメージング / 分子イメージング |
Outline of Final Research Achievements |
A promising MR reporter gene, MagA was used to attempt microglia imaging in glioblastoma in a murine brain tumor model. A chimera MagA transgenic mouse was successfully established and a glioblastoma brain tumor model was produced by implanting murine glioblastoma cells into the brain. Detection of microglia, or any MagA positive cells, however, on MRI was unsuccessful. Taking into account new data published from other institutions, it is speculated that cell toxicity of MagA in murine cell lines interfered with the expression level of MagA within the cells that was targeted to be reported on MRI. On the other hand, our research was able to develop novel image analyzing techniques to identify the tumor heterogeneity and tumor boarder diffuseness using MRI, which characteristics reflect tumor cell biology of gliomas.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Diagnostic and prognostic value of 11C-methionine positron emission tomography for MR non-enhancing glioma.2016
Author(s)
Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Fujimoto Y, Kishima H, Kanemura Y, Nonaka M, Nakajima S, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
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Journal Title
AJNR Am J Neuroradiol
Volume: -
Related Report
Peer Reviewed / Open Access
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[Journal Article] Different spatial distribution of brain metastases from lung cancer by histological subtypes and EGFR mutation status.2016
Author(s)
Takano K, Kinoshita M, Takagaki M, Sakai M, Tateishi S, Achiha T, Hirayama R, Nishino K, Uchida J, Kumagai T, Okami J, Kawaguchi A, Hashimoto N, Nakanishi K, Imamura F, Higashiyama M, Yoshimine T
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Journal Title
Neuro-oncology
Volume: 18
Issue: 5
Pages: 716-724
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas.2016
Author(s)
Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T
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Journal Title
J Neurosurg
Volume: 印刷中
Issue: 5
Pages: 1136-1142
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015
Author(s)
Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
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Journal Title
Cancer Immunology Immunotherapy
Volume: -
Issue: 6
Pages: 707-16
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas.2015
Author(s)
Nakamura T, Tateishi K, Niwa T, Matsushita Y, Tamura K, Kinoshita M, Tanaka K, Fukushima S, Takami H, Arita H, Kubo A, Shuto T, Ohno M, Miyakita Y, Kocialkowski S, Sasayama T, Hashimoto N, Maehara T, Shibui S, Ushijima T, Kawahara N, Narita Y, Ichimura K.
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Journal Title
Neuropathol Appl Neurobiol.
Volume: 42(3)
Issue: 3
Pages: 279-290
DOI
Related Report
Peer Reviewed
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[Journal Article] Olfactory is an overlooked site for the initiation of cerebral malaria.2014
Author(s)
Zhao H, Aoshi T, Kawai S, Mori Y, Fujita Y, Konishi A, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] 2.Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis.2014
Author(s)
Kinoshita M1, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
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Journal Title
Neuro Oncol
Volume: 16
Issue: 5
Pages: 728-734
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Hypofractionated stereotactic radiation therapy in three to five fractions for vestibular schwannoma.2013
Author(s)
Morimoto M, Yoshioka Y, Kotsuma T, Adachi K, Shiomi H, Suzuki O, Seo Y, Koizumi M, Kagawa N, Kinoshita M, Hashimoto N, Ogawa K
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Journal Title
Jpn J Clin Oncol
Volume: 43
Issue: 8
Pages: 805-12
DOI
Related Report
Peer Reviewed
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[Presentation] Different spatial distribution of brain metastasis from lung cancer defined by EGFR mutation status2015
Author(s)
Takano K, Kinoshita M, Takagaki M, Sakai M, Nishino K, Uchida J, Kumagai T, Okami J, Imamura F, Higashiyama M, Hashimoto N, Yoshimine T
Organizer
2015 Society for Neuro-onclogy (SNO) meeting
Place of Presentation
MARRIOTT RIVERCENTER HOTEL(San Antonio TX, USA)
Year and Date
2015-11-20
Related Report
Int'l Joint Research
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[Presentation] A novel PET index, 11C-Methionine/18F-FDG uptake decoupling score, in malignant glioma: Evaluation of its geometrical features for planning radiation therapy2015
Author(s)
Hirata T, Kinoshita M, Arita H, Suzuki O, Hashimoto N, Hatazawa J, Toshiba T, Yoshimine T, Ozawa K
Organizer
2015 Society for Neuro-onclogy (SNO) meeting
Place of Presentation
MARRIOTT RIVERCENTER HOTEL(San Antonio TX, USA)
Year and Date
2015-11-20
Related Report
Int'l Joint Research
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[Presentation] Different spatial distribution between GCB and non-GCB PCNSL revealed by MR group analysis of 100 cases.2013
Author(s)
Kinoshita M, Sasayama T, Narita Y, Kwaguchi A, Yamashita F, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohon M, Miyakita Y, Shizui S, Hashimoto N, Yoshimine T
Organizer
The 4th Quadrennial Meeting of the World Federation of Neuro-Oncology.
Place of Presentation
サンフランシスコ
Related Report
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