Mechanisms of liver carcinogenesis through phospho-Smad by gene-targeted mice
Project/Area Number |
22390153
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kansai Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Kazuichi 関西医科大学, 医学部, 教授 (70145126)
SEKI Toshihito 関西医科大学, 医学部, 教授 (70163087)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
|
Keywords | TGF-β / Smad / Liver fibrosis / Carcinogenesis / TGF-beta / JNK / CDK / シグナル伝達 / 肝発がん / 肝線維化 / 肝発癌 |
Research Abstract |
During progression of chronic liver diseases, chronic inflammation together with somatic mutations shifts hepatocytic phospho-Smad signaling from tumor-suppression to fibro-carcinogenesis, accelerating liver fibrosis and increasing risk of liver cancer. Patients with mild fibrosis respond effectively to therapy by successfully switching Smad phospho-isoform signaling from fibro-carcinogenesis to tumor-suppression, while other therapy responders with advanced liver fibrosis do not (Cytokine & Growth Factor Review in press; Hepatology Research Epub ahead of print).
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C.2013
Author(s)
Yamaguchi T, Matsuzaki K, Inokuchi R, Kawamura R, Yoshida K, Murata M, Fujisawa J, Fukushima N, Sata M, Kage M, Nakashima O, Tamori A, Kawada N, Tsuneyama K, et al.
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Journal Title
Hepatol Res.
Volume: (In press)
Issue: 12
Pages: 1327-42
DOI
Related Report
Peer Reviewed
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[Journal Article] Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer2012
Author(s)
Yijun Wu, Qi Li, Jiren Yu, Yunchuan Mu, Stefan Munker, Chengfu Xu, Zhe Shen, Roman Müllenbach, Yan Liu, Li Li, Norbert Gretz, Derek Zieker, Jun Li, Koichi Matsuzaki
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis.2011
Author(s)
Fukui T., Kishimoto M., Nakajima A., Yamashina M., Nakayama S., Kusuda T., Sakaguchi Y., Yoshida K., Uchida K., Nishio A., Matsuzaki K., Okazaki K.
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Journal Title
Journal of Gastroenterology
Volume: 46
Pages: 456-468
NAID
Related Report
Peer Reviewed
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[Journal Article] Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer
Author(s)
Yijun Wu, Qi Li, Jiren Yu, Yunchuan Mu, Stefan Munker, Chengfu Xu, Zhe Shen, Roman Mullenbach, Yan Liu, Li Li, Norbert Gretz, Derek Zieker, Jun Li, Koichi Matsuzaki, et al
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Journal Title
PLoS ONE
Volume: (in press)
Related Report
Peer Reviewed
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