Function of acetic acid on the prevention in dysfuntion of ageing skeletal muscle
Project/Area Number |
15K07437
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | Okayama Prefectural University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KIMOTO Masumi 岡山県立大学, 保健福祉学部, 教授 (40108866)
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Research Collaborator |
ABE Reina
IWATA Miyuki
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 酢酸 / 骨格筋 / L-6筋管細胞 / 脂肪代謝 / 高齢動物 / 筋管細胞 / 遅筋線維 / ミトコンドリア |
Outline of Final Research Achievements |
In this study, we examined the activation of AMPK and the stimulation of GLUT4 and myoglobin expression by acetic acid in skeletal muscle cells to clarify the physiological function of acetic acid in skeletal muscle cells. Acetic acid added to culture medium was taken up rapidly by L6 cells, and AMPK was phosphorylated upon treatment with acetic acid. We observed increased gene and protein expression of GLUT4 and myoglobin. Furthermore, treated cells also showed increased gene and protein expression of myocyte enhancer factor 2A (MEF2A), which is a well-known transcription factor involved in the expression of myoglobin and GLUT4 genes. These results indicate that acetic acid enhances glucose uptake and fatty acid metabolism through the activation of AMPK, and increases expression of GLUT4 and myoglobin. In addition, this study presented that the treatment of acetic acid would increase expression of PGC1a that involves with mitochondrial generation in skeletal muscle cells.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] 酢酸摂取と運動が脂肪代謝と運動耐久性に及ぼす影響2017
Author(s)
Aya Araki, Yukihiro Yoshimura, Yumiko Yamaguchi, Hitomi Maruta, Masumi Kimoto, Yoshitaka Takahashi, Hiromi Yamashita
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Journal Title
岡山県立大学保健福祉学部紀要 = BULLETIN OF FACULTY OF HEALTH AND WELFARE SCIENCE, OKAYAMA PREFECTURAL UNIVERSITY
Volume: 23
Pages: 21-32
DOI
NAID
URL
Year and Date
2017-03-12
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Seasonal variations and regional differences in major components of oyster from Seto Inland Sea2016
Author(s)
Chiaki Isono, Sari Masaoka, Chihiro Kondo, Ryota Hishimo, Hitomi Maruta, Yukihiro Yoshimura, Yasutaka Hanada, Yoshikuni Ito, Hisanori Hirasawa, Hiromi Yamashita
Organizer
The 10th Joint Conference on Nutrition between Nanchang, Okayama Prefectural, Sichuan and Woosong Universities
Place of Presentation
Woosong University(Korea)
Related Report
Int'l Joint Research
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[Presentation] Effects of Acetic Acid on Composition of Gut Microbiota in Rat2016
Author(s)
Miyuki Iwata, Hitomi Maruta, Yukihiro Yoshimura, Koichi Tanaka, Yasuyuki Irie, Yoshitaka Takahashi, Hiromi Yamashita
Organizer
The 10th Joint Conference on Nutrition between Nanchang, Okayama Prefectural, Sichuan and Woosong Universities
Place of Presentation
Woosong University(Korea)
Related Report
Int'l Joint Research
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[Presentation] Inhibition of leukocyte-type 12-lipoxygenase activity by Chinese tea2015
Author(s)
Yoshiko Mori, Akemi Otsuki, Shuji Okochi, Kensuke Okamoto, Yuki Kawakami, Toshiko Suzuki-Yamamoto, Hiromi Yamashita, Masumi Kimoto, Hideaki Tsuji, Hideyuki Ito, Ding Zhi Fang, Yoshitaka Takahashi
Organizer
12th Asian Congress of Nutrition
Place of Presentation
Pacifico Yokohama(Yokohama)
Year and Date
2015-05-14
Related Report
Int'l Joint Research
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[Book] 分子栄養学2018
Author(s)
山下広美 他
Total Pages
223
Publisher
講談社
ISBN
9784061553972
Related Report
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