Development of Nonlinear Regression Analyses for Personalized Medicine
Project/Area Number |
15K00044
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Statistical science
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Research Institution | Wakayama Medical University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 樹木構造接近法 / アンサンブル学習法 / 治療効果(treatment effect) / 生存時間解析 / 多変量適応型回帰スプライン(MARS) / ルールアンサンブル法 / 治療効果 / 傾向スコア / 観察研究 / 境界内生存期間 / 非比例ハザード性 / レスポンダー同定手法 / サブグループ抽出手法 / 無作為化比較試験 / 適応的指標モデル / ブースティング / 競合リスク / 多変量適応型回帰スプライン / ルール・アンサンブル法 / 順序カテゴリカル応答 |
Outline of Final Research Achievements |
In recent years, personalized medicine, in which optimal treatment is provided to each patient based on registry data or large clinical trials, has been attracting attention.Nonlinear regression methods with treatment × background factors or treatment × gene information interactions have been developed.In addition, statistical methods for predicting the treatment effect (the difference between new and existing treatments/drugs) have recently received much attention.In this study, we have developed a statistical method based on the tree model and its extension to achieve the above goals.
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Academic Significance and Societal Importance of the Research Achievements |
この研究では,近年注目されている疾患レジストリ及び大規模臨床試験データに基づいて,治療効果を推定するための方法を開発した.このような方法は,治療効果モデル(treatment effect model)と呼ばれ,近年注目されている.一方で,医学においてニーズの高い,生存時間データにおける開発は発展途上である.本研究では,生存時間データに対する非線形回帰モデルに基づく治療効果推定の方法を開発した.これらを疾患レジストリデータに応用することで,複数の治療レジメンの中から最適な治療法をがん患者に届けることができる.
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Report
(6 results)
Research Products
(70 results)
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[Journal Article] Trastuzumab With S-1 Plus Cisplatin in HER2-positive Advanced Gastric Cancer Without Measurable Lesions: OGSG 12022019
Author(s)
Endo S, Kurokawa Y, Gamoh M, Kimura Y, Matsuyama J, Taniguchi H, Takeno A, Kawabata R, Kawada J, Masuzawa T, Yamamoto K, Kobayashi K, Sakai D, Shimokawa T, Satoh T.
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Journal Title
Anticancer Research
Volume: 39
Issue: 2
Pages: 1059-1065
DOI
Related Report
Peer Reviewed
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[Journal Article] MAPLE-PD trial (Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer during Pancreaticoduodenectomy): study protocol for a multicenter randomized controlled trial of 354 patients with pancreatic ductal adenocarcinoma2018
Author(s)
Hirono S, Kawai M, Okada KI, Fujii T, Sho M, Satoi S, Amano R, Eguchi H, Mataki Y, Nakamura M, Matsumoto I, Baba H, Tani M, Kawabata Y, Nagakawa Y, Yamada S, Murakami Y, Shimokawa T, Yamaue H.
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Journal Title
Trials
Volume: 19
Issue: 1
Pages: 613-613
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Intensive perioperative rehabilitation improves surgical outcomes after pancreaticoduodenectomy2018
Author(s)
Kitahata Y, Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kobayashi R, Ueno M, Hayami S, Shimokawa T, Kouda K, Tajima F, Yamaue H.
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Journal Title
Langenbeck's Archives of Surgery
Volume: 403
Issue: 6
Pages: 711-718
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Randomized, Open‐Label Phase II Study Comparing Capecitabine‐Cisplatin Every 3 Weeks with S‐1‐Cisplatin Every 5 Weeks in Chemotherapy‐Na?ve Patients with HER2‐Negative Advanced Gastric Cancer: OGSG1105, HERBIS‐4A Trial2018
Author(s)
Kawakami H, Takeno A, Endo S, Makari Y, Kawada J, Taniguchi H, Tamura S, Sugimoto N, Kimura Y, Tamura T, Fujitani K, Sakai D, Shimokawa T, Kurokawa Y, Satoh T.
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Journal Title
The Oncologist
Volume: 23
Issue: 12
Pages: 1411-e147
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Peer Reviewed
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[Journal Article] Splenic vein resection together with the pancreatic parenchyma versus separated resection after isolation of the parenchyma during distal pancreatectomy (COSMOS-DP trial): study protocol for a randomised controlled trial2018
Author(s)
Yamada S, Fujii T, Kawai M, Shimokawa T, Nakamura M, Murakami Y, Satoi S, Eguchi H, Nagakawa Y, Kodera Y, Yamaue H.
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Journal Title
Trials
Volume: 19
Issue: 1
Pages: 369-369
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Efficacy of vonoprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized phase II study2018
Author(s)
Hamada K, Uedo N, Tonai Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Ishihara R, Okada H, Iishi H, Fukui K, Shimokawa T.
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Journal Title
Journal of Gastroenterology
Volume: 54
Issue: 2
Pages: 122-130
DOI
Related Report
Peer Reviewed
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[Journal Article] Delineation of the extent of early gastric cancer by magnifying narrow-band imaging and chromoendoscopy: a multicenter randomized controlled trial2018
Author(s)
Takashi Nagahama, Kenshi Yao, Noriya Uedo, Hisashi Doyama, Tetsuya Ueo, Kunihisa Uchita, Hideki Ishikawa, Takashi Kanesaka, Yasuhito Takeda, Kurato Wada, Kentaro Imamura, Hisatomi Arima, Toshio Shimokawa
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Journal Title
Endoscopy
Volume: -
Issue: 06
Pages: 566-576
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Peer Reviewed
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[Journal Article] Extending magnifying NBI diagnosis of intestinal metaplasia in the stomach: the white opaque substance marker2017
Author(s)
Kanemitsu T., Yao K., Nagahama T., Imamura K., Fujiwara S., Ueki T., Chuman K., Tanabe H., Atsuko O., Iwashita A., Shimokawa T., Uchita K., Kanesaka T.
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Journal Title
Endoscopy
Volume: -
Issue: 06
Pages: 529-535
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients: A randomized controlled clinical trial2016
Author(s)
Imamura H, Nishikawa K, Kishi K, Inoue K, Matsuyama J, Akamaru Y, Kimura Y, Tamura S, Kawabata R, Kawada J, Fujiwara Y, Kawase T, Fukui J, Takagi M, Takeno A, Shimokawa T.
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Journal Title
Ann Surg Oncol.
Volume: 23
Issue: 9
Pages: 2928-2935
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Preoperative neoadjuvant chemotherapy using nanoparticle albumin-bound paclitaxel followed by epirubicin and cyclophosphamide for operable breast cancer: a multicenter phase II trial2016
Author(s)
Futamura M., Nagao Y., Ishihara K., Takeuchi M., Nakada T., Kawaguchi Y., Asano M., Kumazawa I., Shiroko T., Morimitsu K., Mori R., Nawa M., Shimokawa T., Yoshida K.
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Journal Title
Breast Cancer
Volume: -
Issue: 4
Pages: 615-623
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus2015
Author(s)
69.Khoo HM, Kishima H, Tani N, Oshino S, Maruo T, Hosomi K, Yanagisawa T, Kazui H, Watanabe Y, Shimokawa T, Aso T, Kawaguchi A, Yamashita F, Saitoh Y and Yoshimine T
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Journal Title
Journal of Neurosurgery
Volume: 124
Pages: 350-358
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lipid is absorbed in the stomach by epithelial neoplasms (adenomas and early cancers):a novel functional endoscopy technique2015
Author(s)
66.Ohtsu K*, Yao K, Matsunaga K, Nagahama T, Kanemitsu T, Matsushima Y, Yasaka M, Ono Y, Fujiwara S, Hisabe T, Takaki Y, Hirai F, Matsui T, Hanada T, Imamura K, Tanabe H, Iwashita A, Shimokawa T
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Journal Title
Endoscopy International Open
Volume: 3
Issue: 04
Pages: E318-E322
DOI
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Peer Reviewed / Open Access
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[Presentation] A phase II trial of trastuzumab combined with irinotecan in patients with advanced HER2-positive chemo-refractory gastric cancer:OGSG1203 (HERBIS-5)2016
Author(s)
41.Nishikawa K, Sakai D, Kawada J, Kawabata R, Kawase T, Oka Y, Sugimoto B, Shimizu T, Nishijima J, Hasegawa H, Endo S, Isozaki Y, Kimura Y, Matsuyama J, Kurokawa Y, Shimokawa T, Fujitani K, Satoh T
Organizer
2016 Gastrical Cancers Symposum, American Society of Clinical Oncology
Place of Presentation
San Francisco, USA
Year and Date
2016-01-21
Related Report
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[Presentation] A multinational phase II clinical trial of neoadjuvant imatinib for large gastrointestinal stromal tumor of the stomach2016
Author(s)
42.Yang HK, Kurokawa Y, Ryu HM, Cho H, Park SR, Masuzawa T, Lee HJ, Matsumoto S, Kwon OK, Honda H, Lee KH, Yamamoto K, Kong SH, Ishikawa T, Yook JH, Nabeshima K, Hahn S, Shimokawa T, Kang YK, Nishida T
Organizer
2016 Gastrical Cancers Symposum, American Society of Clinical Oncology
Place of Presentation
San Francisco, USA
Year and Date
2016-01-21
Related Report
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[Presentation] A phase II trial of trastuzumab combined with irinotecan in patients with advanced HER2-positive chemo-refractory gastric cancer:Osaka Gastrointestinal Cancer Chemotherapy Study Group OGSG1203 (HERBIS-5)2015
Author(s)
40.Kawabata R, Sakai D, Kawada J, Nishikawa K, Kawase T, Oka Y, Sugimoto N, Shimizu T, Nishijima J, Hasegawa H, Endo S, Isozaki Y, Kimura Y, Matsuyama J, Kurokawa Y, Shimokawa T, Fujitani, Sato T
Organizer
ESMO Asia Congress
Place of Presentation
Singapore
Year and Date
2015-12-18
Related Report
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