Chemokines as novel therapeutic targets in inflammatory arthritis
Project/Area Number |
22790388
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
|
Research Institution | Tohoku University |
Principal Investigator |
INUI Masanori 東北大学, 加齢医学研究所, 講師 (80443985)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 炎症 / 骨破壊 / 関節炎 / ケモカイン / 破骨細胞 |
Research Abstract |
In this study, we examined the physiological roles of C-C chemokines in antigen-induced arthritis and osteoclast development. MIP-1α-CCR1 signaling enhanced inflammatory bone destruction and osteoclast development. Thus, CCL3-CCR1 signaling might be a molecular target for the treatment of inflammatory arthritis.
|
Report
(3 results)
Research Products
(19 results)