Research about S-nitrosylation of proteins related to pathogenesis of Parkinson's disease
Project/Area Number |
26461277
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Osaka University (2017) Nara Medical University (2014-2016) |
Principal Investigator |
Ozawa Kentaro 大阪大学, 医学部附属病院, 医員 (80507393)
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Co-Investigator(Kenkyū-buntansha) |
吉栖 正典 奈良県立医科大学, 医学部, 教授 (60294667)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | nitric oxide / s-nitrosylation / Parkinson's disease / 一酸化窒素 / パーキンソン病 / ミトコンドリア / マイトファジー |
Outline of Final Research Achievements |
I have revealed parkin, a protein related to pathogenesis of Parkinson's disease, is S-nitrosylated and its activity is regulated by S-nitrosylation. To investigate a role of S-nitrosylation of endogenous parkin in degeneration in Parkinson's disease, we generated cell lines which cysteine targeted by S-nitrosylation was converted to another amino acid. Using them, I revealed S-nitrosylation of endogenous parkin is not involved in degradaiton of mitochondria through autophagy but in cell death by mitochondrial stress. These findings indicated S-nitrosylation of parkin might play a important role in cell death by mitochondrial dysfunction and , at least in part, pathogenesis of Parkinson's disease.
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Report
(5 results)
Research Products
(7 results)
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[Journal Article] Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.2017
Author(s)
Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
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Journal Title
Autophagy
Volume: 17
Issue: 5
Pages: 1-14
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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