Rchr
J-GLOBAL ID:200901022938389790
Update date: Mar. 11, 2024
Nishinakamura Ryuichi
ニシナカムラ リユウイチ | Nishinakamura Ryuichi
Affiliation and department:
Job title:
Professor
Research field (1):
Developmental biology
Research theme for competitive and other funds (39):
- 2021 - 2026 Reconstitution of the higher-order structure of the human kidney based on stromal progenitor induction
- 2017 - 2022 Kidney reconstitution and and disease modeling based on nephron induction methods in vitro
- 2018 - 2020 Selective induction of functional epithelia from human iPS cell-derived nephron progenitors
- 2016 - 2019 Propagation of human iPS-derived nephron progenitors in vitro
- 2017 - 2018 Analysis of human kidney deveopment based on the nephron induction method in vitro
- 2016 - 2018 3D logic of S-shaped body formation during kidney development
- 2015 - 2018 ヒトiPSおよび新規遺伝子改変マウスを用いたネフローゼ症候群の病因解明
- 2015 - 2017 発生期腎臓上皮の細胞競合とその破綻による異常
- 2015 - 2017 Reconstitution of renal vasculature based on its development
- 2014 - 2017 In vitro propagation of nephron progenitors from mouse embryo
- 2014 - 2017 Reconstitution of thee-dimensional kidney structures from stem cells
- 2014 - 2016 マウス及びヒト発生期腎臓における管腔上皮形成機構と破綻
- 2013 - 2016 Creating the ureteric bud with a nephron-inducing potential
- 2013 - 2015 腎臓形成におけるネフロン前駆細胞の動態制御
- 2012 - 2014 細胞骨格制御による腎臓上皮形成機構の解明
- 2011 - 2014 Mechanisms regulating the maintenance of nephron progenitors
- 2009 - 2014 Regulation of cellular community of mouse embryos by cell-cell contacts
- 2011 - 2012 Reconstitution of three-dimensional structures from the embryonickidney cells
- 2008 - 2011 Induction of intermediate mesoderm and kidney progenitors from embryonic stem cells
- 2009 - 2010 Elucidation of roles of Dullard, a BMP signal inhibitor in bone formation
- 2009 - 2010 胎児型腎臓幹細胞の成体腎での再活性化
- 2007 - 2008 新規遺伝子による腎臓発生制御機構
- 2007 - 2008 中腎の形成不全に伴う性分化異常の分子機構の解明
- 2006 - 2007 Fate conversion of developing kidney cells
- 2006 - 2007 新規遺伝子群による生殖細胞発生の制御機構
- 2005 - 2006 ES細胞の分化開始にともなうアポトーシス関連蛋白の動態解析
- 2005 - 2006 Adult kidney functions in mice lacking genes that are essential for kidney development
- 2005 - 2006 新規コロニーアッセイ法による腎臓前駆細胞の単離と誘導
- 2004 - 2005 Roles of Sall1 in kidney glomeruli
- 2004 - 2005 Sallファミリーによる腎臓を中心とした臓器発生機構の解明
- 2003 - 2004 霊長類ES細胞維持因子の同定とその機能解析
- 2002 - 2003 腎臓発生におけるSallの分子機構
- 2001 - 2002 Analysis for mechanisms of self-renewal and differentiation signal transduction in human embryonic stem cells.
- 2001 - 2001 腎臓発生に関わる遺伝子群の探索
- 2000 - 2000 Xenopus初期発生におけるサイトカイン受容体及びSTATの役割の解明
- 1999 - 2000 神経幹細胞を特異的に認識するモノクローナル抗体の作製
- 1999 - 2000 胚幹細胞株を用いた血液幹細胞の自己複製能及び分化制御機構の分子生物学的解析
- 1999 - 2000 ANALYSIS FOR MECHANISM OF SELF-RENEWAL SIGNAL TRANSDUCTION IN EMBRYONIC STEM CELLS
- 1997 - 1997 サイトカインレセプターシグナル制御による造血幹細胞の自己複製能及び分化能の解析
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Papers (147):
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Ryuichi Nishinakamura. Advances and challenges toward developing kidney organoids for clinical applications. Cell stem cell. 2023. 30. 8. 1017-1027
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Hiroko Kawakami, Katherine Q Chen, Ruizhi Zhang, Matthew P Pappas, Abigail Bailey, Julie A Reisz, Dylan Corcoran, Ryuichi Nishinakamura, Angelo D'Alessandro, Yasuhiko Kawakami. Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes. Developmental biology. 2023. 501. 28-38
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Shunsuke Tanigawa, Etsuko Tanaka, Koichiro Miike, Tomoko Ohmori, Daisuke Inoue, Chen-Leng Cai, Atsuhiro Taguchi, Akio Kobayashi, Ryuichi Nishinakamura. Author Correction: Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma. Nature communications. 2023. 14. 1. 1874-1874
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Zaili Luo, Dazhuan Xin, Yunfei Liao, Kalen Berry, Sean Ogurek, Feng Zhang, Liguo Zhang, Chuntao Zhao, Rohit Rao, Xinran Dong, et al. Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nature communications. 2023. 14. 1. 762-762
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Yutaro Ibi, Ryuichi Nishinakamura. Kidney Bioengineering for Transplantation. Transplantation. 2023
more...
MISC (115):
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The present and future of kidney organoids. 2024. 42. 5. 721-727
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古家圭士郎, 西中村隆一. 腎臓の再生医療に向けた進歩と展望. 日本腎臓学会誌. 2023. 65. 8. 936-941
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田中悦子, 谷川俊祐, 西中村隆一. 間質前駆細胞誘導法の開発に基づく完全に多能性幹細胞由来腎臓高次構造の構築. 発達腎研究会誌. 2023. 30. 1. 27-32
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西中村隆一. 試験管内で腎臓を作る. きんむ医. 2023. 204. 21-24
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谷川俊祐, 西中村隆一. 腎臓オルガノイドによるポドサイト研究:その現在と未来. 腎臓内科. 2022. 15. 6. 670-676
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Books (5):
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小児泌尿器科学
診断と治療社 2021
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Acute kidney injury and regenerative medicine
Springer 2020
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内科学書
中山書店 2019
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Organ regeneration based on developmental biology
Springer 2017
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Kidney development, disease, repair, and regeneration
Academic Press 2015
Lectures and oral presentations (164):
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Kidney organoids for modeling development and disease
(2023)
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試験管の中で腎臓を作る
(沖縄腎臓病協議会 2023)
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Reconstructing the kidney from pluripotent stem cells
(Clinical application of stem cells in kidney transplantation and nephrology 2023)
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Kidney Organoids with Higher Order Structure
(The 15th International Workshop on Developmental Nephrology 2023)
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Building the kidney in vitro
(2023)
more...
Works (11):
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ES細胞からの腎臓細胞誘導法の開発
2007 - 2008
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新規遺伝子による腎臓発生制御機構
2007 - 2008
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腎臓の細胞運命転換技術の開発
2006 - 2008
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新規遺伝子群による生殖細胞発生の制御機構
2006 - 2008
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ノックアウトマウスを用いた腎臓発生期遺伝子の成体腎障害時における機能解析
2005 - 2007
more...
Education (4):
- - 1996 The University of Tokyo
- - 1996 The University of Tokyo Graduate School, Division of Medical Sciences
- - 1987 The University of Tokyo Faculty of Medicine School of Medicine
- - 1987 The University of Tokyo Faculty of Medicine
Professional career (1):
- Doctor of Medicine (The University of Tokyo)
Work history (6):
- 2009 - 現在 Kumamoto University Institute of Molecular Embryology and Genetics Professor
- 2016/04 - 2020/03 Institute of Molecular Embryology and Genetics, Kumamoto University Director
- 2009 - Professor, ,Institute of Molecular Embryology and Genetics,Kumamoto University
- 2000 - Visiting Associate Professor, The Insitute of Medical Science,The University of Tokyo
- 1996 - The University of Tokyo The Institute of Medical Science
- 1986 - Research Associate,The University of Tokyo
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Association Membership(s) (5):
日本内科学会
, アメリカ腎臓学会
, 日本分子生物学会
, 日本腎臓学会
, American Society of Nephrology
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