- 2022 - 2025 Molecular mechanism of the AID-recombinosome formation which is essential for vaccine-induced antibody gene diversification
- 2022 - 2024 EBV抗原発現調節による、EBV関連胃癌に対する効果的ながん免疫療法の開発
- 2021 - 2023 Mechanistic analysis of the PD-1 blockade combination cancer immunotherapy with BTK inhibitors.
- 2020 - 2023 BTK阻害剤とPD-1抗体のがん免疫併用治療における効果増強メカニズムの解析
- 2019 - 2022 Analysis of the molecular mechanism of IgH gene diversification depending on RNA-editing by AID
- 2017 - 2019 Boosting PD-1 blockade cancer immunotherapy by modulating T cell metabolism
- 2015 - 2019 Regulatory mechanism of immunoglobulin diversification and genome instability through RNA-editing by AID
- 2010 - 2015 Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1
- 2008 - 2010 AIDによる発癌機構の解析とAID阻害剤の探索
- 2007 - 2009 AID変異体ノックインマウスを用いたAIDの生理病態機構解明
- 2005 - 2009 AID-dependent genetic alteration mechanism to generate antigen-specific antibodies
- 2007 - 2008 MicroRNA profiling of human lupus nephritis and murine lupus-like nephritis.
- 2007 - 2008 抗体産生免疫記憶細胞が生ずる分子機構の解明
- 2005 - 2005 AIDによるゲノム情報改編機構の研究
- 2004 - 2004 Regulation of lymphocyte development by Notch/RBP-J signaling
- 2004 - 2004 免疫グロブリンクラススイッチ組み換えを司る分子AIDの制御因子探索の試み
- 2000 - 2004 獲得性生体情報の構築・応答ならびにその異常と病態の研究
- 2002 - 2003 Role of PD-1/PD ligand system in the pathogenesis of rheumatoid arthritis
- 2002 - 2003 PD-1/PD-L1による免疫制御機構の研究
- 2002 - 2003 PD-1の異常による自己免疫病の研究
- 2001 - 2003 PD-1による免疫応答制御と自己免疫病の治療
- 2001 - 2002 Mechanism for autoimmune dilated cardiomyopathy in PD-1-deficient mice
- 1999 - 2002 Regulative Mechanisms and Manipulation of the Germ Cell Lineage
- 1999 - 2002 Regulatory mechanism of signal transduction in the immune system.
- 2000 - 2001 Isolation of PD-1 ligands and their application for immunosuppression
- 1999 - 2000 Study for the ways to promote systematic, advanced medical research
- 1996 - 2000 Molecular Mechanisms and Intervention of Immunological Diseases.
- 1999 - 1999 自己免疫病発症に関与するB-1細胞の発生分化活性化機構の解明
- 1998 - 1999 免疫グロブリン遺伝子導入マウスを利用したヒト型高親和性抗体の作製と抗体遺伝子解析
- 1998 - 1999 Molecular analysis of TSK mouseas a model of scleroderma
- 1995 - 1999 高次生体システムの機能制御の研究.
- 1998 - 1998 Notch細胞質領域のリガンド依存的な切断部位の特定、及びプロテアーゼの同定
- 1997 - 1998 Functional analysis of truncated Notch 1 gene products generated by insertions of mouse mammary tumor proviruses in development of mouse lymphomas.
- 1995 - 1997 Practical Improvement of Signal Sequence Trap Method
- 1996 - 1996 Immune regulation and signal tranduction
- 1996 - 1996 Joint Project for the Investigation of Molecular Mechanism of Class Switch Recombination
- 1996 - 1996 Regulation of Gene Expression
- 1995 - 1996 Establishment of a spontaneous single gene model for Sjogren's syndrome
- 1995 - 1996 Molecular Mechanism for the Class Switch Recombination of immunoglobulin Gene
- 1993 - 1995 Molecular mechanism of immune regulation and immune tolerance
- 1993 - 1994 JAPAN-ITALY PROGRAM ON FRONTIER FIELDS -NATURE AND HUMAN LIFE-
- 1992 - 1994 Mechanisn of lymphocyte differentiation, molecular mechanisms of gene rearrangement and clonal deletion by antigenes
- 1993 - 1993 Studies on molecular mechanisms of autoimmune diseases
- 1992 - 1993 Development of a method for regulation of auto-reactive B cells using transgenic mouse carrying genes encoding an anti-self-erythrocyte antibody.
- 1992 - 1992 免疫制御・寛容の分子機構
- 1992 - 1992 Studies on the regulation of gene expression in lymphoid cells.
- 1991 - 1992 Bリンパ球の運命づけの過程における抗体遺伝子の再構成の制御
- 1991 - 1992 Japan-Italy Program on Frontier Fields Nature and Human Life
- 1991 - 1991 Studies on the regulation of gene expression in lymphoid cells.
- 1990 - 1991 Molecular mechanisms for immunoglobulin class switching
- 1986 - 1990 免疫系における多様性発現機構の分子遺伝学的研究
- 1988 - 1989 Evolution of primate and origin of man.
- 1988 - 1988 リンパ球細胞のTーおよびBー細胞への分化決定機構の解明
- 1988 - 1988 リンパ系腫瘍の免疫関連遺伝子および細胞産生因子遺伝子発現と病態に関する研究
- 1987 - 1987 米国西海岸地域における分子免疫生物学の進捗に関する調査研究
- 1987 - 1987 リンパ系腫瘍の免疫関連遺伝子および細胞産生因子遺伝子発現に関する研究
- 1986 - 1986 人類の起源と系統をめぐる分子進化の研究推進
- 1986 - 1986 細胞の不老不死と腫瘍遺伝子による試験管内発がんの関連
- 1986 - 1986 リンパ系腫瘍の分化抗原発現と免疫グロブリン及びT細胞受容体遺伝子再編成の解析
- 1982 - 1985 リンパ球分化過程における抗体遺伝子の再構成と情報発現調節機構
- 免疫グロブリンクラススイッチと体細胞突然変異の分子機構
- 細胞分化の機構
- 自己免疫病の制御機構
- Molecular mechanism of immunoglobulin class switching and somatic hypermutation
- Molecular mechanism of cell differentiation
- Reglation of autoimmccne diseases
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