Rchr
J-GLOBAL ID:200901068100773866   Update date: Jan. 31, 2024

Honjo Tasuku

ホンジョ タスク | Honjo Tasuku
Affiliation and department:
Job title: Visiting Professor
Homepage URL  (1): http://www2.mfour.med.kyoto-u.ac.jp
Research field  (2): Medical biochemistry ,  Molecular biology
Research keywords  (3): 分子発生学 ,  分子免疫学 ,  Molecular immunology
Research theme for competitive and other funds  (66):
  • 2022 - 2025 Molecular mechanism of the AID-recombinosome formation which is essential for vaccine-induced antibody gene diversification
  • 2022 - 2024 EBV抗原発現調節による、EBV関連胃癌に対する効果的ながん免疫療法の開発
  • 2021 - 2023 Mechanistic analysis of the PD-1 blockade combination cancer immunotherapy with BTK inhibitors.
  • 2020 - 2023 BTK阻害剤とPD-1抗体のがん免疫併用治療における効果増強メカニズムの解析
  • 2019 - 2022 Analysis of the molecular mechanism of IgH gene diversification depending on RNA-editing by AID
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Papers (433):
  • Kenji Chamoto, Baihao Zhang, Masaki Tajima, Tasuku Honjo, Sidonia Fagarasan. Spermidine - an old molecule with a new age-defying immune function. Trends in Cell Biology. 2023
  • Hisato Kawakami, Yu Sunakawa, Eisuke Inoue, Ryo Matoba, Kenta Noda, Toshiyuki Sato, Chihiro Suminaka, Mami Yamaki, Yasuhiro Sakamoto, Ryohei Kawabata, et al. Soluble programmed cell death ligand 1 predicts prognosis for gastric cancer patients treated with nivolumab: Blood-based biomarker analysis for the DELIVER trial. European Journal of Cancer. 2023. 184. 10-20
  • Kenji Chamoto, Tomonori Yaguchi, Masaki Tajima, Tasuku Honjo. Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1. Nature Reviews Immunology. 2023
  • Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda, Tasuku Honjo. Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase. Proceedings of the National Academy of Sciences. 2023. 120. 18
  • Ahmed M. Refaat, Mikiyo Nakata, Afzal Husain, Hidetaka Kosako, Tasuku Honjo, Nasim A. Begum. HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression. Cell Reports. 2023. 42. 3. 112284
more...
MISC (171):
  • 谷崎 潤子, 黒田 浩章, 横山 俊秀, 高濱 誠, 庄田 浩康, 中村 敦, 北村 嘉隆, 豆鞘 伸昭, 門田 嘉久, 光岡 茂樹, et al. 切除可能非小細胞肺癌II-IIIA期における可溶性免疫因子の検討(WJOG12319LTR). 肺癌. 2022. 62. 6. 594-594
  • Ryusuke Hatae, Kenji Chamoto, Young Hak Kim, Kazuhiro Sonomura, Kei Taneishi, Shuji Kawaguchi, Hironori Yoshida, Hiroaki Ozasa, Yuichi Sakamori, Maryam Akrami, et al. Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy. JCI insight. 2020. 5. 2
  • Maki Kobayashi, Misao Takemoto, Tasuku Honjo. The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR. DNA Repair. 2017. 53. 1-3
  • Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo. Cancer immunotherapies targeting the PD-1 signaling pathway. JOURNAL OF BIOMEDICAL SCIENCE. 2017. 24
  • 小林 牧, 若栗 浩幸, 清水 正和, 日笠 幸一郎, 松田 文彦, 本庶 佑. トポイソメラーゼ1を介したAIDによる免疫グロブリン遺伝子の多様化. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [4T27L-04(3P0663)]
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Patents (40):
Books (5):
  • 幸福感に関する生物学的随想
    祥伝社 2020 ISBN:9784396116002
  • がん免疫療法とは何か
    岩波新書 2019
  • 生命科学の未来
    藤原書店 2018
  • いのちとは何か : 幸福・ゲノム・病
    岩波書店 2009 ISBN:9784000050586
  • 遺伝子が語る生命像
    講談社ブルーバックス 1986
Professional career (1):
  • Doctor of Medicine (Kyoto University)
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