Multil-modal analysis of pathological network in epilepsy: challenge targeted for MRI negative epilepsy
Project/Area Number |
15K10361
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Ehime University (2016-2017) Kyoto University (2015) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
松本 理器 京都大学, 医学研究科, 准教授 (00378754)
澤本 伸克 京都大学, 医学研究科, 教授 (90397547)
菊池 隆幸 京都大学, 医学研究科, 助教 (40625084)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | 難治性てんかん / ネットワーク / てんかん外科 / 脳磁図 / 空間フィルター法 / SEEG / MEG / てんかん原生領域 / FDG-PET |
Outline of Final Research Achievements |
Electrocorticography (ECoG) recorded with chronically implanted intracranial can visualize brain activity directly, leading to the identification of epileptogenic areas. Recently, it has been suggested that clinical condition of epilepsy forms pathologically complicated neural network. In this study, we successfully visualized the spatial and temporal organization of epileptogenecity by means of the spatial filter analysis of magnetoencephalogram (MEG), instead of the conventional analysis of equivalent electric current dipole (ECD) model. In addition to this, stereotactic EEG (SEEG) methods was installed as approved clinical research for the intractable epilepsy cases. In comparison with other non-invasive imaging modality, the clinical significance of this new spatial filter analysis in MEG was validated. Eventually, these results contributed to clarify the complicated pathological condition of intractable epilepsy.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity2017
Author(s)
Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Rika Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
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Journal Title
Clin Neurophysiol
Volume: 128
Issue: 5
Pages: 734-743
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms2017
Author(s)
Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R
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Journal Title
Neuroimage
Volume: 15
Pages: 302-313
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway2017
Author(s)
Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
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Journal Title
Human Brain Mapping
Volume: 38 (4)
Issue: 4
Pages: 1977-1991
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy.2016
Author(s)
Imamura, H., R. Matsumoto, S. Takaya, T. Nakagawa, A. Shimotake, T. Kikuchi, N. Sawamoto, T. Kunieda, N. Mikuni, S. Miyamoto, H. Fukuyama, R. Takahashi and A. Ikeda
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Journal Title
Epilepsy Research
Volume: 120
Pages: 65-72
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation.2015
Author(s)
Usami K, Matsumoto R, Kobayashi K, Hitomi T, Shimotake A, Kikuchi T, Matsuhashi M, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A.
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Journal Title
Hum Brain Mapp
Volume: 36(11)
Issue: 11
Pages: 4714-4729
DOI
Related Report
Peer Reviewed / Open Access
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