Relationship between language and motor fibers in dominant side frontal lobe
Project/Area Number |
17K10892
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
松本 理器 京都大学, 医学研究科, 准教授 (00378754)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 補足運動野 / 言語機能 / supplementary motor area / language function / narrative reading task / laterality / frontal aslant tract / 脳神経疾患 / 運動機能 / 前頭葉 |
Outline of Final Research Achievements |
Connectivity within dominant frontal lobe was reliably evaluated by cortico-cortical evoked potential recording. Due to small sample size, we could not obtain enough reproducible result in the relationship between connectivity gradient and functional localization. We are continuing patient inclusion and intraoperative recording. As for the relationship between connectivity within dominant frontal lobe and language function, we tested functional MRI using language task and revealed that the lateralization of activation in the supplementary motor area is strongly related to the language lateralization revealed by intraarterial propofol testing.
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Academic Significance and Societal Importance of the Research Achievements |
言語表出に関わると推定される前頭葉内の接続性を電気生理学的に評価する方法を確立したことは、今後の脳内ネットワーク解明の一助となると考えられるとともに、臨床の面からは信頼性の高い言語機能の一面の評価方法として、術中判断の材料となる可能性を有する。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study2020
Author(s)
Takuro Nakae, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Katsuya Kobayashi, Akihiro Shimotake, Yukihiro Yamao, Takayuki Kikuchi, Toshihiko Aso, Masao Matsuhashi, Kazumichi Yoshida, Akio Ikeda, Ryosuke Takahashi, Matthew A Lambon Ralph, Susumu Miyamoto
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Journal Title
Cerebral Cortex
Volume: -
Issue: 8
Pages: 4633-4650
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Intraoperative electrophysiological mapping of medial frontal motor areas and functional outcomes2020
Author(s)
Sumiya Shibata, Yukihiro Yamao, Takeharu Kunieda, Rika Inano, Takuro Nakae, Sei Nishida, Taku Inada, Yuki Takahashi, Takayuki Kikuchi, Yoshiki Arakawa, Kazumichi Yoshida, Riki Matsumoto, Akio Ikeda, Tatsuya Mima, Susumu Miyamoto
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Journal Title
World Neurosurgery
Volume: 4
Pages: 389-404
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Human entorhinal cortex electrical stimulation evoked short-latency potentials in the broad neocortical regions: Evidence from cortico-cortical evoked potential recordings2019
Author(s)
Hirofumi Takeyama, Riki Matsumoto, Kiyohide Usami, Takuro Nakae, Katsuya Kobayashi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
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Journal Title
Brain and Behavior
Volume: 9
Issue: 9
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation.2019
Author(s)
Usami K, Korzeniewska A, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Kunieda T, Mikuni N, Kikuchi T, Yoshida K, Miyamoto S, Takahashi R, Ikeda A, Crone NE.
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Journal Title
Sleep.
Volume: in press
Issue: 6
Pages: 1-9
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A rational, multispectral mapping algorithm for primary motor cortex: A primary step before cortical stimulation2019
Author(s)
Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Takefumi Hitomi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto, Susumu Miyamoto, Ryosuke Takahashi, Hirofumi Maruyama, Akio Ikeda
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Journal Title
Epilepsia
Volume: 60
Issue: 3
Pages: 547-559
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interictal Slow and High-Frequency Oscillations: Is it an Epileptic Slow or Red Slow?2018
Author(s)
Inoue T, Inouchi M, Matsuhashi M, Matsumoto R, Hitomi T, Daifu-Kobayashi M, Kobayashi K, Nakatani M, Kanazawa K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
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Journal Title
J Clin Neurophysiol.
Volume: 36
Issue: 2
Pages: 166-170
DOI
Related Report
Peer Reviewed
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[Journal Article] Resting-state functional magnetic resonance imaging identifies cerebrovascular reactivity impairment in patients with arterial occlusive diseases: A pilot study2018
Author(s)
Nishida S, Aso T, Takaya S, Takahashi Y, Kikuchi T, Funaki T, Yoshida K, Okada T, Kunieda T, Togashi K, Fukuyama H, Miyamoto S
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Journal Title
Neurosurgery
Volume: Epub ahead of print
Issue: 5
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study.2017
Author(s)
Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
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Journal Title
Sleep
Volume: 40
Issue: 8
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity2017
Author(s)
Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Rika Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
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Journal Title
Clin Neurophysiol
Volume: 128
Issue: 5
Pages: 734-743
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway2017
Author(s)
Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
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Journal Title
Human Brain Mapping
Volume: 38 (4)
Issue: 4
Pages: 1977-1991
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 定位頭蓋内電極留置精度の評価と向上に向けた取り組み2020
Author(s)
菊池隆幸, 山尾幸広, 永井靖識, 松本直樹, 下竹昭寛, 小林勝哉, 吉田和道, 國枝武治, 松本理器, 池田昭夫, 宮本享
Organizer
日本てんかん外科学会
Related Report
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[Presentation] 覚醒下手術におけるてんかん原性領域検索の可能性2019
Author(s)
菊池隆幸, 山尾幸広, 稲田拓, 永井靖識, 松本直樹, 川崎敏生, 下竹昭寛, 溝田敏幸, 荒川芳輝, 吉田和道, 池田昭夫, 宮本享
Organizer
日本Awake Surgery学会
Related Report
Invited
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[Presentation] フレーム式定位脳手術装置とアンカーボルトを用いた定位頭蓋内電極留置法の導入経験2019
Author(s)
菊池隆幸, 山尾幸広, 永井靖識, 松本直樹, 下竹昭寛, 小林勝哉, 吉田和道, 國枝武治, 松本理器, 池田昭夫, 宮本享
Organizer
日本てんかん学会
Related Report
Invited
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