Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis.
Abstract
The natural polyphenol compound resveratrol (RSV) is considered to have a broad spectrum of beneficial biological activities upon human health. However, the exact effect of RSV on steatosis (a phenotype of non-alcoholic fatty liver [NAFL]) or fibrosis and inflammation (major phenotypes of non-alcoholic steatohepatitis [NASH]) is not known. Our data showed that administration of RSV (2 or 20 mg/kg/day) did not suppress steatosis in a high-fat diet-induced model of NAFL in mice. In contrast, identical concentrations of RSV dramatically inhibited inflammation and fibrosis in a low-dose lipopolysaccharide-induced model of NASH. These data suggested that RSV administration-mediated improvement of inflammation and fibrosis was due to the inhibition of LPS reactivity controlled by CD14 expression in Kupffer cells. These findings suggest that RSV could be a candidate agent for the treatment of NASH.
Journal
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- Scientific Reports
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Scientific Reports 6 22251-1-22251-11, 2016-02-25
Springer Nature
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Keywords
Details
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- CRID
- 1050564288439581696
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- NII Article ID
- 120005749754
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- ISSN
- 20452322
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- Web Site
- http://ir.lib.shimane-u.ac.jp/35111
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles