Elucidation of mechanisms related to toxicity and susceptibility of various fatty acids in NASH pathology
Project/Area Number |
15K19340
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Yokohama City University |
Principal Investigator |
OGAWA Yuji 横浜市立大学, 医学部, 助教 (20644959)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | lipotoxicity / NAFLD / NASH / palmitate / saturated fatty acid / 飽和脂肪酸 / NAFLD/NASH |
Outline of Final Research Achievements |
In this study, after palmitate-injection, basal diet (BD)-fed mice did not altered the serum ALT, but high fat diet (HFD)-fed mice exhibited increased the serum ALT. Very low dose lipopolysaccharide (LPS)-injection increased the plasma endotoxin on BD-fed mice as same as HFD-fed mice. Both palmitate and very low dose LPS increased ALT on BD-fed mice. On BD-fed mice, palmitate induced inflammatory cells infiltration due to chemokines without ALT elevation and induced mild liver fibrosis via toll like receptor 4 (TLR4) pathway. Collectively, palmitate alone induced inflammatory cells infiltration and mild liver fibrosis without ALT elevation. Furthermore, palmitate exacerbated NAFLD pathogenesis by cooperative interaction with gut-derived endotoxin. Our results indicate that serum palmitate and plasma gut-derived endotoxin reduction are important for NAFLD treatment.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis.2017
Author(s)
Honda Y, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Fujita K, Yoneda M, Takizawa T, Saito S, Nagashima Y, Nakajima A.
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 42477-42477
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The characteristics of non-obese NAFLD: Effect of genetic and environmental factors.2016
Author(s)
Honda Y, Yoneda M, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Mawatari H, Fujita K, Hyogo H, Ueno T, Chayama K, Saito S, Nakajima A, Hotta K
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Journal Title
Hepatol Res
Volume: -
Issue: 10
Pages: 636-636
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Saturated fatty acid, palmitate, induced liver inflammation and fibrosis in vivo.2016
Author(s)
Yuji Ogawa, Yasushi Honda, Takaomi Kessoku, Wataru Tomeno, Shingo Kato, Kento Imajo, Hironori Mawatari, Koji Hujita, Masato Yoneda, Satoru Saito, Atsushi Nakajima
Organizer
The international liver congress 2016
Place of Presentation
Fira Barcelona Gran Via(Barcerona, Spain)
Year and Date
2016-04-16
Related Report
Int'l Joint Research
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