Technical ReportSevere ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background
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Supplementary Information accompanies the paper on the Laboratory Investigation website
Jingling Shen and Dan Shi: These authors contributed equally to this work.
Retinol binding protein 4 (RBP4) is a specific carrier for retinol in the blood. The authors produced Rbp4-deficient mice on a C57BL/6 genetic background. These mice display more severe and longer lasting retinal structural abnormalities than an older model using mice with a mixed genetic background. Furthermore, with the new model they show that RBP4 is critical for the mobilization of retinol from hepatic storage pools, and that such mobilization is necessary for ocular development and visual function.
Supplementary information: The online version of this article (doi:10.1038/labinvest.2016.39) contains supplementary material, which is available to authorized users.