Usefulness as the biomarker and effect in the iron metabolism of new splicing variant of hepcidin with liver cancer origin
Project/Area Number |
15K19302
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | ヘプシジン / スプライシングバリアント / バイオマーカー |
Outline of Final Research Achievements |
I built the system of measurement to detect hepcidin mRNA and splicing variant of hepcidin mRNA from serum exosome with Digital PCR. Splicing variant of hepcidin mRNA was not detected in healthy person and liver cirrhosis patients without the past of the liver cancer, but it was detected in some liver cirrhosis patients with the past of the liver cancer and liver cancer patients. Splicing variant of hepcidin mRNA was not detected in pancreatic cancer, stomach cancer, and colon cancer patients. From these results, splicing variant of hepcidin mRNA was considered as new useful biomarker in the liver cancer.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] A selective splicing variant of hepcidin mRNA in hepatocellular carcinoma cell lines.2016
Author(s)
Toki Y, Sasaki K, Tanaka H, Yamamoto M, Hatayama M, Ito S, Ikuta K, Shindo M, Hasebe T, Nakajima S, Sawada K, Fujiya M, Torimoto Y, Ohtake T, Kohgo Y.
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Journal Title
Biochem Biophys Res Commun.
Volume: 476
Issue: 4
Pages: 501-507
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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