Ohizumi Yasushi 大泉康

… Alternative Names

Researcher Number	00006355
Affiliation (Current)	2021: 静岡県立大学, 薬学部, 客員教授
Affiliation (based on the past Project Information) *help	1999 – 2005: Graduate School of Pharmaceutical Sciences, Tohoku University, Professor, 大学院・薬学研究科, 教授 1991 – 1998: 東北大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / Biological pharmacy / Science and Engineering / Bioorganic chemistry / 医薬分子機能学 Except Principal Investigator Chemical pharmacy / Biological pharmacy / Biological pharmacy
Keywords	Principal Investigator ゴニオドミンA / アポトーシス / カルシウム / アクチン / 海洋微生物 / ハレナキノン / MAPキナーゼ / チャンネル / カフェイン / 血管平滑筋 … More Except Principal Investigator V-1 / CapZ / 抗うつ / 強制水泳試験 / 無動時間 / 吉草根 / カカオ / 5-HT_<2C>受容体 / PC12D細胞 / 神経成長因子増強作用 / 神経突起伸張作用 / 天然素材 / PC12 / antidepressant / kanokodiol / newrite outgrowth / nerve growth factor / nantenine / 5-HT receptor / structure-activity relationship / molecular modeling / ミオシン / アクチン / トロポニン / トロポミオシン / 超沈殿 / 横紋筋 / 生理活性物質 / goniodomin A / 心筋 / 骨格筋 / myosin / actin / troponin / tropomyosin / superprecipitation / skeletal muscle / アクチンダイナミックス / 転写制御 / TH遺伝子 / 神経新生 / 脳機能再生 / 中枢神経変性疾患 / レトロウイルスベクター / アクチンフィラメント形成 / 神経機能制御 / 神経再生 / 脳神経幹細胞 / 天然ハーブエキス / 蛋白質相互作用 / neurosphere / Actin dynamics / Transcriptional regulation / TH gene / Neurogenesis / Regeneratin of brain function / CNS neurodegeneration Less

新しい医薬資源からの抗がん性物質の探索と分子標的の解明Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Elucidation of physiological significance of a novel regulator of neuronal functions and its application to functional regeneration of brain
- Principal Investigator
  
  YAMAKUNI Tohru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
新しい医薬資源からの抗がん性物質の分子標的の解明Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
新しい医薬資源からの抗腫瘍性天然物の探索とその分子標的の解明Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
神経細胞の分化を制御する微量天然生理活性物質の探索およびその作用解析Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
新しい医薬資源からの抗腫瘍性天然物の探索とその分子標的および作用機序の解明Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
神経細胞の分化を制御する天然の微量物質の探索およびその作用機序Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
新しい分子標的抗がん剤開発を目的として新規抗腫瘍性天然物の探索と作用機序の解明Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Pharmacological study of intarcellular signal transduction using marine natural products as pharmacological tools.Principal Investigator
- Principal Investigator
  
  OHIZUMI Yasushi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
新しい医薬資源の開拓と新規抗腫瘍性天然物の作用機序の解明Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Search for psychotropic drugs from new natural resources and study on their mechanism of action and application to medicines
- Principal Investigator
  
  MATSUNAGA Kimihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tohoku University
Applicatory study using actomyosin ATPase affecting compound for therapy of family hypertrophic cardiomyopathy
- Principal Investigator
  
  SAITO Shin-ya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
新しい医療資源からの抗腫瘍成分の作用機序の解明Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Pharmacological studies on bioactive compounds isolated from marine organismsPrincipal Investigator
- Principal Investigator
  
  OHIZUMI Yasushi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Applicatory study of natural compounds with receptor blocking effect to vasodilatorPrincipal Investigator
- Principal Investigator
  
  OHIZUMI Yasushi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  TOHOKU UNIVERSITY
新しい医薬資源からの抗腫瘍性成分の検索とその作用機序の解明Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
イオンチャネル機能探索分子の開発と情報伝達機構解明への応用Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
海洋生物および生薬に含まれる抗腫瘍成分の化学および生物学的研究Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Elucidation of the mechanism of excitatory action of marine natural products on platelets and muscle cellsPrincipal Investigator
- Principal Investigator
  
  OHIZUMI Yasushi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
海洋生物および生薬に含まれる抗腫瘍性成分の化学および生物学的研究Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
イオンチャネルとその活性調節物質による超分子形成Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
海洋生物に含まれる抗腫瘍性成分の化学および生物学的研究Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
超活性海洋天然物とその生命科学への応用Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
海洋微生物に含まれる抗腫瘍性成分の化学および生物学的研究Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
強力なカフェイン感受性チャンネル開口薬MBEDを用いたCa遊離チャンネルの研究Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Pharmacological studies on toxins from marine organismPrincipal Investigator
- Principal Investigator
  
  OHIZUMI Yasushi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  TOHOKU UNIVERSITY
Basic and applied studies on cardiotonicPrincipal Investigator
- Principal Investigator
  
  OHIZUMI Yasushi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  TOHOKU UNIVERSITY
強力なカフェイン感受性チャンネル開口薬MBEDを用いたCa遊離チャンネルの研究Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
強力なカフェイン感受性チャンネル開口薬MBEDを用いたCa遊離チャンネルの研究Principal Investigator
- Principal Investigator
  
  大泉康
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University

All 2006 2005 2004 Other

All Journal Article

[Journal Article] Garcinone B reduces prostaglandin E_2 release and NF-κB-mediated transcription in C_6 cells.2006
- Author(s)
  Yamakuni, T., Aoki, K., Nakatani, K., Kondo, N., Oku, H., Ishiguro, K., Ohizumi, Y.
- Journal Title
  
  Neurosci.Lett. 394
  
  Pages: 206-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Garcinone B reduces prostaglandin E_2 release and NF-κB-mediated transcription in C6 rat glioma cells.2006
- Author(s)
  T.Yamakuni, Y.Ohizumi et al.
- Journal Title
  
  Neuroscience Letters (印刷中)
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] V-1 enhances PMA-induced activation of NF-κB-dependent transcription in PC12D cells.2006
- Author(s)
  Hiwatashi, Y., Yamakuni, T., Ohizumi, Y.
- Journal Title
  
  Pharmacometrics 70
  
  Pages: 17-20
- NAID
  10020344516
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats2006
- Author(s)
  Matsuzaki, K., Yamakuni, T., Hashimoto, M., Haque, A.M., Shido, O., Mimaki, Y., Sashida, Y., Ohizumi, Y.
- Journal Title
  
  Neurosci.Lett. 400
  
  Pages: 230-234
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Nobiletin and its related flavonoids with CRE-dependent transcription- stimulating and neuritegenic activities.2005
- Author(s)
  Nagase, H., Omae, N., Omori, A., Nakagawasai, O., Tadano, T., Yokosuka, A., Sashida, Y., Mimaki, Y., Yamakuni, T., Ohizumi, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 377
  
  Pages: 1330-1336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-κB-dependent transcription in C6 rat glioma cells.2005
- Author(s)
  Aoki, K., Yamakuni, T., Yoshida, M., Ohizumi, Y.
- Journal Title
  
  J.Pharmacol.Sci. 98
  
  Pages: 327-330
- NAID
  10025729227
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Intracellular cAMP controls a physical association of V-1 with Cap Z in cultured mammalian endocrine cells.2005
- Author(s)
  Kitazawa, M., Yamakuni, T., Song, S.-Y., Kato, C., Tsuchiya, R., Ishida, M., Suzuki, N., Adachi, E., Iwashita, S., Ueno, S., Yanagihara, N., Taoka, M., Isobe, T., Ohizumi, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 331
  
  Pages: 181-186
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Mechanism of neurotropic action of nobiletin in PC12D cells.2005
- Author(s)
  Nagase, H., Yamakuni, T., Matsuzaki, K., Maruyama, Y., Kasahara, J., Fukunaga, K., Hinohara, Y., Kondo, S., Mimaki, Y., Sashida, Y., Tank, A.W., Ohizumi, Y.
- Journal Title
  
  Biochemistry 44
  
  Pages: 13683-13691
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Acidosis-induced protein tyrosine phosphorylation depends on Ca^<2+> influx via voltage-dependent Ca^<2+> channels in SHR aorta2004
- Author(s)
  D.K.Rohra, T.Yamakimi, Y.Ohizumi
- Journal Title
  
  European Journal of Pharmacology 504
  
  Pages: 105-111
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Acidosis-induced protein tyrosine phosphorylation depends on Ca^<2+> influx via voltage-dependent Ca^<2+> channels in SHR aorta.2004
- Author(s)
  Rohra, D.K., Yamakuni, T., Ohizumi, Y.
- Journal Title
  
  Eur.J.Pharmacol. 504
  
  Pages: 105-111
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] _Y-Mangostin inhibits inhibitor-κB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.2004
- Author(s)
  Nakatani, K., Yamakuni, T., Kondo, N., Arakawa, T., Oosawa, K., Shimura, S., Ohizumi, Y.
- Journal Title
  
  Mol.Pharmacol. 66
  
  Pages: 667-674
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.2004
- Author(s)
  Rohra, D.K., Yamakuni, T., Ito, S., Saito, S., Ohizumi, Y.
- Journal Title
  
  Pharmacology 71
  
  Pages: 10-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] IC101 induces apotosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells.2004
- Author(s)
  Fujiwara, H., Yamakuni, T., Ueno, M., Ishizuka, M., Shinkawa, T., Isobe, T., Ohizumi, Y.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 310
  
  Pages: 1288-1295
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Potent antioxidative activity of unripe fruits of Garcinia mangostana L.2004
- Author(s)
  Feng.J., Yamakuni, T., Katoh, E., Hosoda, S., Ohizumi, Y.
- Journal Title
  
  Natural Medicines 58
  
  Pages: 156-159
- NAID
  110008732316
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Proinsulin C-peptide stimulates a PKC/Iκ B/NF-κ B signaling pathway
- Author(s)
  Kitazawa, M., Shibata, Y., Hashimoto, S., Ohizumi, Y., T., Yamakuni
- Journal Title
  
  J.Biochemi. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041

1. NAKAHATA Norimichi (60045804)

# of Collaborated Projects: 19 results

# of Collaborated Products: 0 results
2. MATSUNAGE Kimihiro (90222306)

# of Collaborated Projects: 18 results

# of Collaborated Products: 0 results
3. FURUKAWA Ken-ichi (20165468)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
4. SAITO Shinya (80271849)

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
5. NAKATANI Keigo (60281979)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
6. YAMAKUNI Tohru (30333793)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
7. MATSUOKA Setsu (40238986)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 李玉山 (50344685)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. YAGIMUMA Toshiko (00250803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. NAKAJIMA Akira (20419237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 北条博史 (90004621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 北川勲 (20028830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山田静之 (90022540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 唐木英明 (60011912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 安元健 (20011885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小林淳一 (90221241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ISHIKAWA Kiyofumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. IKEMOTO Fumihiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. UMEDA Asami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KITADA Yoshimi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TAKIGUCHI Toshio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YASUDA Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ISHIDA Yukisato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 斎藤真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohizumi Yasushi 大泉 康

OHIZUMI Yasushi 大泉 康

Research Projects

Research Products

Co-Researchers

新しい医薬資源からの抗がん性物質の探索と分子標的の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of physiological significance of a novel regulator of neuronal functions and its application to functional regeneration of brain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新しい医薬資源からの抗がん性物質の分子標的の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新しい医薬資源からの抗腫瘍性天然物の探索とその分子標的の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経細胞の分化を制御する微量天然生理活性物質の探索およびその作用解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新しい医薬資源からの抗腫瘍性天然物の探索とその分子標的および作用機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経細胞の分化を制御する天然の微量物質の探索およびその作用機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新しい分子標的抗がん剤開発を目的として新規抗腫瘍性天然物の探索と作用機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pharmacological study of intarcellular signal transduction using marine natural products as pharmacological tools.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新しい医薬資源の開拓と新規抗腫瘍性天然物の作用機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Search for psychotropic drugs from new natural resources and study on their mechanism of action and application to medicines

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Applicatory study using actomyosin ATPase affecting compound for therapy of family hypertrophic cardiomyopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新しい医療資源からの抗腫瘍成分の作用機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Ohizumi Yasushi 大泉康

OHIZUMI Yasushi 大泉康