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OTSUKI Makoto  大槻 眞

ORCIDConnect your ORCID iD *help
… Alternative Names

大槻 眞  オオツキ マコト

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Researcher Number 00030916
Other IDs
Affiliation (based on the past Project Information) *help 2008: 産業医科大学, 医学部, 名誉教授
1998 – 2008: 産業医科大学, 医学部, 教授
1995 – 1996: 産業医科大学, 医学部, 教授
1989: 神戸大学, 医学部附属病院, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology
Except Principal Investigator
Gastroenterology / Gastroenterology
Keywords
Principal Investigator
survivin / mRNA / proliferation / regeneration / antiapoptotic effect / apoptosis / acute pancreatitis / 腺房細胞 / 膵管細胞 / Survivin … More / 膵腺房細胞 / 膵管上皮細胞 / differential display / 膵炎後肺障害 / 出血性壊死性膵炎 / nineteen kD interacting protein-3 like protein / 細胞増殖 / 再生 / 抗アポトーシス / アポトーシス / 急性膵炎 / CCK-A receptor / transgenic rat / OLETF rat / ノックアウトラット / CCK-A受容体 / トランスジェニック / OLETFラット / TGF-beta / Extracellular Matrix / Fibrosis / Pancreatitis / オレイン酸膵炎 / アルギニン膵炎 / 膵線維化 / 慢性膵炎 / TGF-β / 細胞外基質 / 線維化 / 膵炎 / 蛋白キナ-ゼC / インスリン結合 / 膵癌 / 消化管ホルモン … More
Except Principal Investigator
matrix metalloproteinase / Smad6 / TGF-β / TGF-beta / 慢性膵炎 / antioxidant / pancreatic stellate cells / alcohol-related pancreatic injury / 膵腺房細胞 / 恒久的胃瘻モデルラット / 緑茶ポリフェノール / 抗酸化剤 / 膵星細胞 / アルコール性膵障害 / Fibrosis / Endothelin / Chronic Pancreatitis / 繊維化 / 線維化 / 膵繊維化 / エンドセリン / Treatment / Diabetes Mellitus / Liver cirrhosis / 耐糖能異常 / 肝線維化 / 肝癌 / 治療 / 耐糖能障害 / 肝硬変 / Cholecystokinin / Leptin / Functional dyspepsia / コレシストキニン / レプチン / 機能性ディスペプシア / fibrosis / transgenic mouse / トランスジェ-ニック / トランスジェーニック / ペースメーカー機構 / 膵外分泌 / Smad3 / 膵再生 / Smad / トランスジェニックマウス / 膵線維化 / チューインガム / 胃食道逆流症 Less
  • Research Projects

    (12 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (11 People)
  •  Chewing bicarbonate-containing gum as a treatment option for gastroesophageal reflux disease

    • Principal Investigator
      YOSHIKAWA Ichiro
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Elucidation of pathological mechanism of the pancreatic fibrosis in chronic pancreatitis.

    • Principal Investigator
      NAKAMURA Hayato
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  膵外分泌ペースメーカー機構の解明

    • Principal Investigator
      山本 光勝
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Strategy of treatment for diabetes mellitus with liver cirrhosis

    • Principal Investigator
      TABARU Akinari
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Gene Therapy of Chronic Pancreatitis by Antisense Endothelin and Variant-type Endothelin Receptors

    • Principal Investigator
      KIHARA Yasuyuki
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Pathophysiology of alcohol-related pancreatic injury

    • Principal Investigator
      TASHIRO Mitsuo
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Apoptosis and anti-apoptosis in pancreatic diseasesPrincipal Investigator

    • Principal Investigator
      OTSUKI Makoto
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Role of gastric leptin and cholecystokinin in patients with functional dyspepsia

    • Principal Investigator
      YOSHIKAWA Ichiro
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health
  •  Pancreatic fibrosis and diabetes in transgenic OLETF rat expressing CCK-A receptor

    • Principal Investigator
      NAKAMURA Makoto
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health
  •  Pancreatic fibrosis and diabetes in transgenic OLETF rat expressing CCK-A receptorPrincipal Investigator

    • Principal Investigator
      OTSUKI Makoto
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Heath
  •  Role of extracellular matrix, cytokines and gut hormones on pancreatic fibrosis in arginine-induced pancreatitis.Principal Investigator

    • Principal Investigator
      OTSUKI Makoto
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Occupational and Environmental Health
  •  膵癌細胞増殖における特異的遺伝子発現に対する膵ホルモン及び消化管ホルモンの作用Principal Investigator

    • Principal Investigator
      大槻 眞
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kobe University

All 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models.2008

    • Author(s)
      Nakamura H, Tashiro M, Asaumi H, Nomiyama Y, Kaku M, Watanabe S, Miyamoto T, Otsuki M.
    • Journal Title

      Gut. 57(6)

      Pages: 788-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590691
  • [Journal Article] Preferential increase of extracellular matrix expression relative to transforming growth factor beta1 in the pancreas during the early stage of acute hemorrhagic pancreatitis in rats.2007

    • Author(s)
      Nakamura H, Tashiro M, Yamaguchi T, Asaumi H, Nomiyama Y, Watanabe S, Nagashio Y, Miyamoto T, Otsuki M.
    • Journal Title

      Pancreas. 35(4)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590691
  • [Journal Article] High glucose activates rat pancreatic stellate cells through protein kinase C and p38 mitogen-activated protein kinase pathway.2007

    • Author(s)
      Nomiyama Y, Tashiro M, Yamaguchi T, Watanabe S, Taguchi M, Asaumi H, Nakamura H, Otsuki M.
    • Journal Title

      Pancreas. 34(3)

      Pages: 364-72

    • NAID

      10024366871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590691
  • [Journal Article] Green tea polyphenol(-)-epigallocatechin-3-gallate inhibits ethanol-induced activation of pancreatic stellate cells.2006

    • Author(s)
      Asaumi H, Watanabe S, Taguchi M, Tashiro M, Nagashio Y, Nomiyama Y, Nakamura H, Otsuki M.
    • Journal Title

      M. Eur J Clin Invest. 36(2)

      Pages: 113-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590691
  • [Journal Article] Persistent destruction of the basement membrane of the pancreatic duct contributes to progressive acinar atrophy in rats with experimentally induced pancreatitis.2005

    • Author(s)
      Yamaguchi T, Kihara Y, Taguchi M, Nagashio Y, Tashiro M, Nakamura H, Otsuki M.
    • Journal Title

      Pancreas. 31(4)

      Pages: 365-72

    • NAID

      130004495719

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590691
  • [Presentation] Increased Expression of Smad6 Deteriorates Murine Acute Pancreatitis.2008

    • Author(s)
      Hayato Nakamura, Hiroshi Asaumi, Yoko Nomiyama, Shiro Watanabe and Makoto Otsuki.
    • Organizer
      DDW2008
    • Place of Presentation
      San Diego
    • Year and Date
      2008-05-18
    • Data Source
      KAKENHI-PROJECT-17590691
  • [Presentation] Increased expression of Smad6 deteriorates murine Acute edematous pancreatitis.2006

    • Author(s)
      Nakamura H, Tashiro M, Asaumi H, Nomiyama Y, Watanabe S, Miyamoto T, Otsuki M.
    • Organizer
      7th World Congress of the International Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Edinburgh, Scotland
    • Year and Date
      2006-09-03
    • Data Source
      KAKENHI-PROJECT-17590691
  • [Presentation] Smad6トランスジェニック・マウスにおけるアミラーゼ分泌反応と膵内トリプシン活性化.2005

    • Author(s)
      中村早人, 角みどり, 田代充生, 大槻眞
    • Organizer
      第36回日本膵臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-29
    • Data Source
      KAKENHI-PROJECT-17590691
  • [Presentation] Smad6トランスジェニック・マウスにおけるaction dynamicsとアミラーゼ分泌反応2005

    • Author(s)
      中村早人, 角みどり, 田代充生, 大槻眞
    • Organizer
      第47回 日本消化器病学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2005-10-05
    • Data Source
      KAKENHI-PROJECT-17590691
  • 1.  NAKAMURA Hayato (90207902)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 9 results
  • 2.  KIHARA Yosuyuki (80279330)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  TASHIRO Mitsuo (20341498)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 8 results
  • 4.  YOSHIKAWA Ichiro (60210655)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  AKIYAMA Toshiharu (10320350)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TAGUCHI Masashi (80369058)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KUME Keiichiro (20320351)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TABARU Akinari (50188405)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NARITA Ryoichi (30320352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  山本 光勝 (10341497)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  井本 逸勢 (30258610)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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