MOROI Masaaki 諸井将明

… Alternative Names

諸井将明モロイマサアキ

MASAAKI Moroi 諸井将明

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Researcher Number	00049074
Other IDs
Affiliation (Current)	2025: 久留米大学, 付置研究所, 教授
Affiliation (based on the past Project Information) *help	2007 – 2008: Kurume University, 分子生命科学研究所, 教授 2003 – 2005: 久留米大学, 分子生命科学研究所, 教授 1999 – 2000: 久留米大学, 分子生命科学研究所, 教授 1995: 久留米大学, 分子生命科学研究所, 教授 1993: 久留米大学, 分子生命科学研究所, 教授 … More 1990: 久留米大学, 分子生命科学研・生化学, 教授 1989: 久留米大学, 分子生命科学研, 教授 1986 – 1989: 自治医科大学, 医学部, 助教授 1988: 自治医科大学, 第二生化学, 助教授 1986: 自治医大, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator 血管生物学 / 物質生物化学 / Cell biology / Cell biology / General medical chemistry Except Principal Investigator General surgery / Basic veterinary science/Basic zootechnical science
Keywords	Principal Investigator GPVI / 血小板 / コラーゲン / GPIb / Platelet / 血栓症 / 粘着反応 / biosynthesis / thrombosis / polymorphism … More / GPII b / glycoprotein / グリコカリシン / GP【II】b / GP【I】b / 血小板無力症 / 生合成 / 多様性 / GPIIb / 糖蛋白 / Rap 1 / tyrosine phosphorylation / Rap1 / チロシンリン酸化 / ADP RECEPTOR / INTEGRIN α2β1 / COLLAGEN / PLATELET / ADPレセプター / インテグリンα2β1 / 膜透過性ペプチド / コラーゲン受容体 / 抗体 / 阻害剤 / シグナル伝達 / ズリ応力 … More Except Principal Investigator 分子異常症 / プロテインC / アンチトロンビンIII / 血栓塞栓症 / ADP / トロンボキサンA_2 / 血小板凝集 / 血小板膜糖蛋白 / 血小板膜受容体 / 血小板 / Thrombus formation / Thromboembolic disease / Monoclonal antibodies / Protein C / Abnormal fibrinogen / Molecular abnormality / 血液凝固制御機構 / 血管内皮細胞 / トロンビン-アンチトロンビンIII複合体 / 遺伝子解析 / モノクロナル抗体 / 異常フィブリノゲン / 血栓形成 / abnormal fibrinogen / abnormal protein C / protein C / abnormal antithrombin III / antithrombin III / thromboembolism / Surgical thromboembolic diseases / プロテインC分子異常症 / プロテインC欠損症 / アンチトロンビン【III】欠損症 / アンチトロンビン【III】 / 深部静脈血栓症 / 血栓塞栓性疾患 / フィブリノゲン異常症 / プロテインC異常症 / 異常アンチトロンビンIII / 外科的血栓塞栓疾患 / Chediak-Higashi syndrome / signal transduction system / synergism / platelet aggregation / thromboxane A2 / species difference / collagen / Chedaik-Higashi症候群 / 凝集 / Chediak-Higashi症候群 / シグナル伝達 / 協力作用 / 動物種差 / コラーゲン / トロンボスポンジン / 白血球接着分子 / コラゲン / トロンビン / 血小板無力症 / 血栓 / 遺伝子工学 / コラ-ゲン / 免疫電顕 / モノクロ-ナル抗体 Less

Analysis of the active structure and activation mechanism of platelet collagen receptor GPVI using GPVI-specific inhibitorsPrincipal Investigator
- Principal Investigator
  
  MOROI Masaaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kurume University
Analysis of Signal Transducing Mechanism in Platelet-Analysis using Proteomics and Cell-permeable ReagentsPrincipal Investigator
- Principal Investigator
  
  MOROI Masaaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Studies on the signal transduction system of platelet collagen receptor that is related to species difference of hemostasis
- Principal Investigator
  
  ITO Katsuaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  University of Miyazaki
Analysis of the Activation of Platelet Integrin α2β1 and its Physiological FunctionPrincipal Investigator
- Principal Investigator
  
  MASAAKI Moroi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
微細血管流血下における止血開始機構の解析-新しい測定装置を用いた血小板反応の解析Principal Investigator
- Principal Investigator
  
  諸井将明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Kurume University
血小板の血管内皮下組織に対する粘着反応の解析-特に血小板膜糖蛋白GPVIの関与-Principal Investigator
- Principal Investigator
  
  諸井将明
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Kurume University
血小板膜の構造と機能
- Principal Investigator
  
  山崎博男
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
血小板膜の構造と機能
- Principal Investigator
  
  山崎博男
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Studies on the pathogenesis and pathophysiology of thromboembolisms in the field of surgery. Development of novel techniques for analyzing the regulatory systems of blood coagulation.
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School
Studies on pathophysiology of surgical thromboembolic diseases with special reference to impaired regulation of blood coagulation.
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School
Structure and function of platelet membrane glycoproteins-analysis of their mechanism using gene analysis and affinity labellingPrincipal Investigator
- Principal Investigator
  
  MOROI MASAAKI
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Jichi Medical School

All 2008 2007 2004 2003

All Journal Article Presentation Book

[Book] Platelet glycoprotein VI. "Multichain immune recognition receptor signaling from spatiotemporal organization to human disease" Ed; Sigalov AB2008
- Author(s)
  Jung SM, Moroi M
- Publisher
  Landes Bioscience
- Data Source
  KAKENHI-PROJECT-19590292
[Book] Platelet collagen receptors. "Recent Advances in Thrombosis and Hemostasis 2008" Eds; Tanaka K, Davie EW2008
- Author(s)
  Jung SM, Moroi M
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] Collagen-type specificity of glycoprotein VI as a determinant of plateletadhesion2008
- Author(s)
  Jung SM, Takemura Y, Imamura Y, Hayshi T, Adachi E, Moroi M
- Journal Title
  
  Platelets 19
  
  Pages: 32-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] Collagen-type specificity of glycoprotein VI as a determinant of platelet adhesion.2008
- Author(s)
  Jung SM, Takemura Y, Imamura Y, Hayshi T, Adachi E, Moroi M
- Journal Title
  
  Platelets 19(1)
  
  Pages: 32-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura.2008
- Author(s)
  Gardiner EE, Al-Tamimi M, Mu FT, Karunakaran D, Thom JY, Moroi M, Andrews RK, Berndt MC, Baker RI
- Journal Title
  
  J Thromb Haemost 6(7)
  
  Pages: 1175-1182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] Expression of the TAF4b gene is induced by MYC through a non-canonical, E-box which contributes to its specific response to MYC.2008
- Author(s)
  Teye K, Okamoto K, Tanaka Y, Umata T, Ohnuma M, Moroi M, Kimura H, Tsuneoka M
- Journal Title
  
  Int J Oncol 33(6)
  
  Pages: 1271-1280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] A mechanism to safeguard platelet adhesion under high shearf low:von Willebrand factor-glycoprotein Ib and integrin alpha2betal-collagen interaction smake complementary,collagen-type-specific contributions to adhesion2007
- Author(s)
  Moroi M, Jung SM
- Journal Title
  
  J Thromb Haemost 5
  
  Pages: 797-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI.2007
- Author(s)
  Wijeyewickrema LC, Gardiner EE, Moroi M, Berndt MC, Andrews RK
- Journal Title
  
  Thromb Haemost 98(6)
  
  Pages: 1285-1290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] A mechanism to safegurard platelet adhesion under high-shear flow: von Willebrand factor-glycoprotein alpha2beta1-collagen interactions make complementary, collagen-type-specific contributions to adhesion: reply to a rebuttal.2007
- Author(s)
  Moroi M, Jung SM
- Journal Title
  
  J Thromb Haemost 5(6)
  
  Pages: 1340-1342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alpha2beta1-collagen interactions make complementary, collagen-type-specific contributions to adhesion.2007
- Author(s)
  Moroi M, Jung SM
- Journal Title
  
  J Thromb Haemost 5(4)
  
  Pages: 797-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] Snake venom metalloproteinases,crotarhagin and alborhagin,induce ectodomain shedding of the platelet collagen receptor,glycoprotein VI2007
- Author(s)
  Wijeyewickrema LC, Gardiner EE, Moroi M, Berndt MC, Andrews RK
- Journal Title
  
  Thromb Haemost 98
  
  Pages: 1285-1290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590292
[Journal Article] Platelet glycoprotein VI : its structure and function2004
- Author(s)
  Moroi, M.
- Journal Title
  
  Thromb. Res. 114・2
  
  Pages: 221-233
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570163
[Journal Article] Platelet glycoprotein VI : its structure and function2004
- Author(s)
  Moroi, M et al.
- Journal Title
  
  Thromb.Res. 105-2
  
  Pages: 221-233
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570163
[Journal Article] Platelet glycoprotein VI : its structure and function2004
- Author(s)
  Moroi, M
- Journal Title
  
  Thromb. Res. 114・2
  
  Pages: 221-233
- Data Source
  KAKENHI-PROJECT-16570163
[Journal Article] A new monoclonal antibody, mAb 204-11, that influence the binding of platelet GPVI to fibrous collagen2003
- Author(s)
  Moroi, M., Mizuguchi, J., Kawashima, S., Ito, K., Jung, S.M.et al.
- Journal Title
  
  Thrombosis Haemostasis 89(6)
  
  Pages: 996-1003
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580261
[Journal Article] A new monoclonal antibody, mAb 204-11, that influences the binding of platelet GPVI to fibrous collagen2003
- Author(s)
  Moroi, M., Mizuguchi, J., Kawashima, S., Ito, K., Jung, S.M.et al.
- Journal Title
  
  Thrombosis Haemostasis 89(6)
  
  Pages: 996-1003
- Data Source
  KAKENHI-PROJECT-15580261
[Journal Article] A new monoclonal antibody, mAb 204-11, that influences the binding of platelet GPVI to fibrous collagen2003
- Author(s)
  Moroi, M., Mizuguchi, J., Kawashima, S., Nagamatsu, M., Miura, Y., Nakagaki, T., Ito, K, Jung, S.M.
- Journal Title
  
  Thrombosis Haemostasis 89(6)
  
  Pages: 996-1003
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580261
[Presentation] GPVI二量体を認識する組換Fab抗体2008
- Author(s)
  諸井将明他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19590292
[Presentation] Recombinant anti-GPVI Fab recognizing a specific conformation of the GPVI dimer.2008
- Author(s)
  Masaaki Moroi et al.
- Organizer
  The Third United Kingdom-Japan Platelet Conference
- Place of Presentation
  Singapore
- Year and Date
  2008-09-17
- Data Source
  KAKENHI-PROJECT-19590292
[Presentation] Recombinant anti-GPVI Fab recognizing a specific conformation of the GPVI dimer2008
- Author(s)
  Moroi, M., et al.
- Organizer
  The Third UK-Japan Platelet Conference
- Place of Presentation
  Singapore
- Year and Date
  2008-09-17
- Data Source
  KAKENHI-PROJECT-19590292

1. OHNUMA Masaaki (20223901)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. MIURA Yoshiki (90279240)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. YOSHIDA Nobuhiko (10049083)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MATSUDA Michio (50048980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SAKATA Yoichi (40129028)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MURAYAMA Hideki (70146166)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 山崎博男 (50013826)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 加藤淳 (50183265)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 斉藤佑尚 (30134810)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 大熊稔 (50026986)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 木幡陽 (30030852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. ICHIRO Onitsuka (10289431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ITO Katsuaki (70136795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. TERUKINA Shigeharu (80146159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SUGO Teruko (60183844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MIMURO Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MAEKAWA Hisato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 前川久登

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 三室淳

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MOROI Masaaki 諸井 将明

諸井 将明 モロイ マサアキ

MASAAKI Moroi 諸井 将明

Research Projects

Research Products

Co-Researchers

Analysis of the active structure and activation mechanism of platelet collagen receptor GPVI using GPVI-specific inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Signal Transducing Mechanism in Platelet-Analysis using Proteomics and Cell-permeable ReagentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the signal transduction system of platelet collagen receptor that is related to species difference of hemostasis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the Activation of Platelet Integrin α2β1 and its Physiological FunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

微細血管流血下における止血開始機構の解析-新しい測定装置を用いた血小板反応の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血小板の血管内皮下組織に対する粘着反応の解析-特に血小板膜糖蛋白GPVIの関与-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血小板膜の構造と機能

Principal Investigator

Project Period (FY)

Research Category

Research Institution

血小板膜の構造と機能

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Studies on the pathogenesis and pathophysiology of thromboembolisms in the field of surgery. Development of novel techniques for analyzing the regulatory systems of blood coagulation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on pathophysiology of surgical thromboembolic diseases with special reference to impaired regulation of blood coagulation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure and function of platelet membrane glycoproteins-analysis of their mechanism using gene analysis and affinity labellingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Platelet glycoprotein VI. "Multichain immune recognition receptor signaling from spatiotemporal organization to human disease" Ed; Sigalov AB2008

Author(s)

Publisher

Data Source

[Book] Platelet collagen receptors. "Recent Advances in Thrombosis and Hemostasis 2008" Eds; Tanaka K, Davie EW2008

Author(s)

Publisher

Data Source

[Journal Article] Collagen-type specificity of glycoprotein VI as a determinant of plateletadhesion2008

Author(s)

MOROI Masaaki 諸井将明

諸井将明モロイマサアキ

MASAAKI Moroi 諸井将明